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. 1968 Sep;47(9):2000–2015. doi: 10.1172/JCI105887

Studies of peripheral thyroxine distribution in thyrotoxicosis and hypothyroidism

John T Nicoloff 1,2,3, J Thomas Dowling 1,2,3
PMCID: PMC297362  PMID: 4175319

Abstract

Compartmental analysis of the peripheral distribution of labeled thyroxine was applied to various groups of subjects with thyrotoxicosis and hypothyroidism. It was observed that the hepatic incorporation of thyroxine was augmented in subjects with Graves' disease when compared to non-Graves' disease control groups at all levels of thyroid function. Decreased values of hepatic incorporation occurred in primary hypothyroid subjects. These lowered values were not acutely corrected by elevation of the serum thyroxine level, but were observed to be rectified after several months' therapy with exogenous thyroid hormone. These alterations of the hepatic thyroxine-131I incorporation were independently verified by direct quantitative liver scintiscan determinations.

Employing a dual thyroxine tracer system, we were able to demonstrate that during the early phases of equilibration of a tracer dose of thyroxine, alterations in the rate of deiodination were observed to be present in the various thyroid disease states. Increased deiodination rates were found in subjects with Graves' disease and the reverse was noted in patients with primary hypothyroidism. Kinetic analysis of thyroxine compartmental distribution during this early phase of equilibration of a labeled thyroxine tracer indicated that the primary tissue uptake occurred in the liver. These findings supported the contention that the amount of labeled thyroxine incorporated in the liver may be directly related to the deiodination rate of thyroxine by that organ. The pathogenetic basis of these alterations is presently unknown.

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2000

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ALBERT A., KEATING F. R., Jr The role of the gastrointestinal tract, including the liver, in the metabolism of radiothyroxine. Endocrinology. 1952 Nov;51(5):427–443. doi: 10.1210/endo-51-5-427. [DOI] [PubMed] [Google Scholar]
  2. BARKER S. B., HUMPHREY M. J., SOLEY M. H. The clinical determination of protein-bound iodine. J Clin Invest. 1951 Jan;30(1):55–62. doi: 10.1172/JCI102416. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. BLOMSTEDT B., PLANTIN L. O. THE EXTRATHYROIDAL DISTRIBUTION OF 131-I THYROXINE. Acta Endocrinol (Copenh) 1965 Apr;48:536–546. doi: 10.1530/acta.0.0480536. [DOI] [PubMed] [Google Scholar]
  4. Cavalieri R. R., Searle G. L. The kinetics of distribution between plasma and liver of 131-I-labeled L-thyroxine in man: observations of subjects with normal and decreased serum thyroxine-binding globulin. J Clin Invest. 1966 Jun;45(6):939–949. doi: 10.1172/JCI105409. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. FORD D. H., COREY K. R., GROSS J. The localization of thyroid hormones in the organs and tissues of the guinea pig: an autoradiographic and chromatographic study. Endocrinology. 1957 Oct;61(4):426–447. doi: 10.1210/endo-61-4-426. [DOI] [PubMed] [Google Scholar]
  6. Gorman C. A., Flock E. V., Owen C. A., Jr, Paris J. Factors affecting exchange of thyroid hormones between liver and blood. Endocrinology. 1966 Aug;79(2):391–405. doi: 10.1210/endo-79-2-391. [DOI] [PubMed] [Google Scholar]
  7. INGBAR S. H., FREINKEL N. Studies of thyroid function and the peripheral metabolism of I 131-labeled thyroxine in patients with treated Graves disease. J Clin Invest. 1958 Nov;37(11):1603–1614. doi: 10.1172/JCI103753. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Inada M., Sterling K. Thyroxine Turnover and Transport in Laennec's Cirrhosis of the Liver. J Clin Invest. 1967 Aug;46(8):1275–1282. doi: 10.1172/JCI105620. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. LENNON E. J., ENGBRING N. H., ENGSTROM W. W. Studies of the rate of disappearance of labeled thyroxine from the intravascular compartment. J Clin Invest. 1961 Jun;40:996–1005. doi: 10.1172/JCI104339. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Nicoloff J. T., Dowling J. T. Estimation of thyroxine distribution in man. J Clin Invest. 1968 Jan;47(1):26–37. doi: 10.1172/JCI105712. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. ROCHE J., MICHEL R. On the peripheral metabolism of thyroid hormones. Ann N Y Acad Sci. 1960 Apr 23;86:454–468. doi: 10.1111/j.1749-6632.1960.tb42822.x. [DOI] [PubMed] [Google Scholar]
  12. VAN MIDDLESWORTH L., TURNER J. A., LIPSCOMB A. Liver function related to thyroxine metabolism. J Nucl Med. 1963 Mar;4:132–138. [PubMed] [Google Scholar]
  13. VANNOTTI A., BERAUD T. Functional relationships between the liver, the thyroxine-binding protein of serum, and the thyroid. J Clin Endocrinol Metab. 1959 Apr;19(4):466–477. doi: 10.1210/jcem-19-4-466. [DOI] [PubMed] [Google Scholar]
  14. Volpert E. M., Martinez M., Oppenheimer J. H. Radioiodinated impurities in commercial preparations of 131-I-thyroxine and their effect on the measurement of free thyroxine in human serum by equilibrium dialysis. J Clin Endocrinol Metab. 1967 Mar;27(3):421–428. doi: 10.1210/jcem-27-3-421. [DOI] [PubMed] [Google Scholar]
  15. Webster B. R., Britton A., Volpé R., Ezrin C. Further studies on the rate of disappearance of labelled thyroxine from the intravascular compartment of man, with reference to the role of thyroxine binding proteins. Acta Endocrinol (Copenh) 1967 Jul;55(3):497–521. doi: 10.1530/acta.0.0550497. [DOI] [PubMed] [Google Scholar]

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