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. 1969 Nov;48(11):2046–2056. doi: 10.1172/JCI106170

Studies of the pituitary-Leydig cell axis in young men with hypogonadotropic hypogonadism and hyposmia: comparison with normal men, prepuberal boys, and hypopituitary patients

C Wayne Bardin 1, Griff T Ross 1, Arleen B Rifkind 1, Charles M Cargille 1, Mortimer B Lipsett 1
PMCID: PMC297457  PMID: 4390462

Abstract

Pituitary and gonadal function was studied in seven chromatin-negative men, ages 15-27 yr, with retarded sexual and somatic development, skeletal anomalies, and hyposmia. These hyposmic patients were compared with normal men, prepuberal boys and hypogonadal patients with hypopituitarism. The urinary follicle-stimulating hormone (FSH) and luteinizing hormone (LH) levels of hyposmic subjects were the same as those of normal boys and hypopituitary patients but significantly lower than those of normal men. Clomiphene citrate did not cause an increase in plasma FSH and LH levels in either hypogonadal group as it does in normal men. In contrast to hypopituitary patients, thyroid and adrenocortical function and release of growth hormone in the hyposmic subjects were normal. The plasma testosterone levels were equally low in prepuberal, hypopituitary, and hyposmic patients but were increased to a greater extent by human chorionic gonadotropin (HCG) treatment in prepuberal and hypopituitary subjects than in the hyposmic patients. Prolonged treatment with HCG has failed to return plasma testosterone levels to normal in two hyposmic patients. These observations suggest that there are defects of both pituitary and Leydig cell function in men with the syndrome of hypogonadism, skeletal anomalies, and hyposmia. They have impaired secretion of FSH and LH and a Leydig cell insensitivity to gonadotropin.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ALBERT A., UNDERDAHL L. O., GREENE L. F., LORENZ N. Male hypogonadism. IV. The testis in prepubertal or pubertal gonadotropic failure. Proc Staff Meet Mayo Clin. 1954 Feb 24;29(4):131–136. [PubMed] [Google Scholar]
  2. BRASEL J. A., WRIGHT J. C., WILKINS L., BLIZZARD R. M. AN EVALUATION OF SEVENTY-FIVE PATIENTS WITH HYPOPITUITARISM BEGINNING IN CHILDHOOD. Am J Med. 1965 Apr;38:484–498. doi: 10.1016/0002-9343(65)90127-0. [DOI] [PubMed] [Google Scholar]
  3. Bardin C. W., Lipsett M. B. Estimation of testosterone and androstenedione in human peripheral plasma. Steroids. 1967 Jan;9(1):71–84. doi: 10.1016/0039-128x(67)90090-6. [DOI] [PubMed] [Google Scholar]
  4. Bardin C. W., Ross G. T., Lipsett M. B. Site of action of clomiphene citrate in men: a study of the pituitary-Leydig cell axis. J Clin Endocrinol Metab. 1967 Nov;27(11):1558–1564. doi: 10.1210/jcem-27-11-1558. [DOI] [PubMed] [Google Scholar]
  5. Cargille C. M., Rodbard D., Ross G. T. Radioimmunoassay of human follicle stimulating hormone: bias due to antisera. J Clin Endocrinol Metab. 1968 Sep;28(9):1276–1280. doi: 10.1210/jcem-28-9-1276. [DOI] [PubMed] [Google Scholar]
  6. Cargille C. M., Ross G. T., Bardin C. W. Clomiphene and gonadotrophin in men. Lancet. 1968 Dec 14;2(7581):1298–1298. doi: 10.1016/s0140-6736(68)91787-x. [DOI] [PubMed] [Google Scholar]
  7. DE MORSIER G. Etudes sur les dysraphies crânio-encéphaliques. I. Agénésie des lobes olfactifs (télencéphaloschizis latéral) et des commissures calleuse et antérieure (télencéphaloschizis médian); la dysplasie olfacto-génitale. Schweiz Arch Neurol Psychiatr. 1954;74(1-2):309–361. [PubMed] [Google Scholar]
  8. ELWERS M., CRITCHLOW V. Precocious ovarian stimulation following hypothalamic and amygdaloid lesions in rats. Am J Physiol. 1960 Feb;198:381–385. doi: 10.1152/ajplegacy.1960.198.2.381. [DOI] [PubMed] [Google Scholar]
  9. ELWERS M., CRITCHLOW V. Precocious ovarian stimulation following interruption of stria terminalis. Am J Physiol. 1961 Aug;201:281–284. doi: 10.1152/ajplegacy.1961.201.2.281. [DOI] [PubMed] [Google Scholar]
  10. Frasier S. D., Horton R. Androgens in the peripheral plasma of prepubertal children and adults. Steroids. 1966 Nov;8(5):777–784. doi: 10.1016/0039-128x(66)90017-1. [DOI] [PubMed] [Google Scholar]
  11. GAUTHIER G. [Olfacto-genital dysplasia (agenesis of the olfactory lobes with absence of gonadal development at puberty]. Acta Neuroveg (Wien) 1960;21:345–394. doi: 10.1007/BF01228269. [DOI] [PubMed] [Google Scholar]
  12. GLICK S. M., ROTH J., YALOW R. S., BERSON S. A. IMMUNOASSAY OF HUMAN GROWTH HORMONE IN PLASMA. Nature. 1963 Aug 24;199:784–787. doi: 10.1038/199784a0. [DOI] [PubMed] [Google Scholar]
  13. HECHT A., RUSKIN H. Seminiferous tubule dysgenesis (Klinefelter's syndrome) associated with familiar cerebellar ataxia. J Clin Endocrinol Metab. 1960 Aug;20:1184–1190. doi: 10.1210/jcem-20-8-1184. [DOI] [PubMed] [Google Scholar]
  14. Hembree W. C., Ross G. T. Arginine infusion and growth-hormone secretion. Lancet. 1969 Jan 4;1(7584):52–52. doi: 10.1016/s0140-6736(69)91011-3. [DOI] [PubMed] [Google Scholar]
  15. Kohler P. O., O'Malley B. W., Rayford P. L., Lipsett M. B., Odell W. D. Effect of pyrogen on blood levels of pituitary trophic hormones. Observations of the usefulness of the growth hormone response in the detection of pituitary disease. J Clin Endocrinol Metab. 1967 Feb;27(2):219–226. doi: 10.1210/jcem-27-2-219. [DOI] [PubMed] [Google Scholar]
  16. Kulin H. E., Rifkind A. B., Ross G. T. Human luteinizing hormone (LH) activity in processed and unprocessed urine measured by radioimmunoassay and bioassay. J Clin Endocrinol Metab. 1968 Apr;28(4):543–546. doi: 10.1210/jcem-28-4-543. [DOI] [PubMed] [Google Scholar]
  17. Lipsett M. B., Wilson H., Kirschner M. A., Korenman S. G., Fishman L. M., Sarfaty G. A., Bardin C. W. Studies on Leydig cell physiology and pathology: secretion and metabolism of testosterone. Recent Prog Horm Res. 1966;22:245–281. doi: 10.1016/b978-1-4831-9825-5.50009-9. [DOI] [PubMed] [Google Scholar]
  18. Lynch H. T., Kaplan A. R., Henn M. J., Krush A. J. Familial coexistence of diabetes mellitus, hyperlipemia, short stature, and hypogonadism. Am J Med Sci. 1966 Sep;252(3):323–330. doi: 10.1097/00000441-196609000-00012. [DOI] [PubMed] [Google Scholar]
  19. MATTHEWS W. B., RUNDLE A. T. FAMILIAL CEREBELLAR ATAXIA AND HYPOGONADISM. Brain. 1964 Sep;87:463–468. doi: 10.1093/brain/87.3.463. [DOI] [PubMed] [Google Scholar]
  20. MULLER P. DIE OLFACTO-GENITALE DYSPLASIE. Gynaecologia. 1964;158:137–142. [PubMed] [Google Scholar]
  21. McARTHUR J. W. The identification of pituitary interstitial cell stimulating hormone in human urine. Endocrinology. 1952 Mar;50(3):304–310. doi: 10.1210/endo-50-3-304. [DOI] [PubMed] [Google Scholar]
  22. NOWAKOWSKI H., LENZ W. Genetic aspects in male hypogonadism. Recent Prog Horm Res. 1961;17:53–95. [PubMed] [Google Scholar]
  23. Odell W. D., Ross G. T., Rayford P. L. Radioimmunoassay for luteinizing hormone in human plasma or serum: physiological studies. J Clin Invest. 1967 Feb;46(2):248–255. doi: 10.1172/JCI105527. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. Poznanski W., Bennett J., McKendry J. B. Urinary steroid pattern in male hypogonadotrophic hypogonadism. Can Med Assoc J. 1967 Feb 4;96(5):273–277. [PMC free article] [PubMed] [Google Scholar]
  25. ROSEWATER S., GWINUP G., HAMWI G. J. FAMILIAL GYNECOMASTIA. Ann Intern Med. 1965 Sep;63:377–385. doi: 10.7326/0003-4819-63-3-377. [DOI] [PubMed] [Google Scholar]
  26. Rifkind A. B., Kulin H. E., Ross G. T. Follicle-stimulating hormone (FSH) and luteninizing hormone (LH) in the urine of prepubertal children. J Clin Invest. 1967 Dec;46(12):1925–1931. doi: 10.1172/JCI105682. [DOI] [PMC free article] [PubMed] [Google Scholar]
  27. SPENCER PEET J., DALY J. R., SMITH V. A SIMPLE METHOD FOR IMPROVING THE SPECIFICITY OF THE FLUORIMETRIC DETERMINATION OF ADRENAL CORTICOSTEROIDS IN HUMAN PLASMA. J Endocrinol. 1965 Feb;31:235–244. doi: 10.1677/joe.0.0310235. [DOI] [PubMed] [Google Scholar]
  28. STEELMAN S. L., POHLEY F. M. Assay of the follicle stimulating hormone based on the augmentation with human chorionic gonadotropin. Endocrinology. 1953 Dec;53(6):604–616. doi: 10.1210/endo-53-6-604. [DOI] [PubMed] [Google Scholar]
  29. Saez J. M., Bertrand J. Studies on testicular function in children: plasma concentrations of testosterone, dehydroepiandrosterone and its sulfate before and after stimulation with human chorionic gonadotrophin. (1). Steroids. 1968 Dec;12(6):749–761. doi: 10.1016/s0039-128x(68)80029-7. [DOI] [PubMed] [Google Scholar]
  30. Sparkes R. S., Simpson R. W., Paulsen C. A. Familial hypogonadotropic hypogonadism with anosmia. Arch Intern Med. 1968 Jun;121(6):534–538. [PubMed] [Google Scholar]
  31. VOLPE R., METZLER W. S., JOHNSTON M. W. Familial hypogonadotrophic eunuchoidism with cerebellar ataxia. J Clin Endocrinol Metab. 1963 Jan;23:107–115. doi: 10.1210/jcem-23-1-107. [DOI] [PubMed] [Google Scholar]
  32. WILSON H., LIPSETT M. B. Use of periodate oxidation in the clinical analysis of urine corticoids. Anal Biochem. 1963 Mar;5:217–225. doi: 10.1016/0003-2697(63)90119-2. [DOI] [PubMed] [Google Scholar]
  33. Wieland R. G., Folk R. L., Taylor J. N., Hamwi G. J. Studies of male hypogonadism. I. Androgen metabolism in a male with gynecomastia and galactorrhea. J Clin Endocrinol Metab. 1967 Jun;27(6):763–767. doi: 10.1210/jcem-27-6-763. [DOI] [PubMed] [Google Scholar]

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