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. 2010 Nov;20(11):1215–1228. doi: 10.1089/thy.2009.0349

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Copyright 2010, Mary Ann Liebert, Inc.

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FIG. 10. — Varying levels of central hypothyroidism (onset at t = 0) simulated using the SCR model with TSH secretion rates (SR_TSH) ranging from 100% down to 0.1% of normal. Top left: TSH circadian oscillation over 1 day in steady state. Top right: TSH in central hypothyroidism over 60 days. Inset graph: first day of simulated TSH, showing a rapid decline in TSH, followed by a slow rise to steady-state levels (shown top left). Bottom: T₃ and T₄ in central hypothyroidism over 60 days. Color images available online at www.liebertonline.com/thy.