Skip to main content
PMC home page
The Journal of Clinical Investigation logoLink to The Journal of Clinical Investigation
. 1969 Dec;48(12):2359–2366. doi: 10.1172/JCI106202

Cori cycle activity in man

Christine Waterhouse 1,2, Julian Keilson 1,2
PMCID: PMC297493  PMID: 5355347

Abstract

12 subjects have been studied after an overnight fast with trace amounts of pyruvate-3-14C and glucose-6-14C. Blood disappearance curves and incorporation of the pyruvate-3-14C label into blood glucose have been determined. By the use of transfer functions which allow processes with many different chemical steps to be examined as a unit, we have determined the per cent of pyruvate and presumably lactate which is regenerated into glucose. 8 of the 12 subjects showed that 7-23 mg/kg per hr are recycled, while 4 subjects fell well outside this range. Correlation of increased activity was not good with any demonstrated metabolic abnormality (diabetes or obesity), and it is suggested from clinical observation of the subjects that anxiety may play a role.

Full text

PDF
2359

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BLAIR A., SEGAL S. The isolation of blood glucose as potassium gluconate. J Lab Clin Med. 1960 Jun;55:959–964. [PubMed] [Google Scholar]
  2. Cahill G. F., Jr, Herrera M. G., Morgan A. P., Soeldner J. S., Steinke J., Levy P. L., Reichard G. A., Jr, Kipnis D. M. Hormone-fuel interrelationships during fasting. J Clin Invest. 1966 Nov;45(11):1751–1769. doi: 10.1172/JCI105481. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Kreisberg R. A. Glucose metabolism in normal and obese subjects. Effect of phenformin. Diabetes. 1968 Aug;17(8):481–488. doi: 10.2337/diab.17.8.481. [DOI] [PubMed] [Google Scholar]
  4. MYERS J. D. Net splanchnic glucose production in normal man and in various disease states. J Clin Invest. 1950 Nov;29(11):1421–1429. doi: 10.1172/JCI102380. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Pitts F. N., Jr, McClure J. N., Jr Lactate metabolism in anxiety neurosis. N Engl J Med. 1967 Dec 21;277(25):1329–1336. doi: 10.1056/NEJM196712212772502. [DOI] [PubMed] [Google Scholar]
  6. SACKS W. CEREBRAL METABOLISM OF DOUBLY LABELED GLUCOSE IN HUMANS IN VIVO. J Appl Physiol. 1965 Jan;20:117–130. doi: 10.1152/jappl.1965.20.1.117. [DOI] [PubMed] [Google Scholar]
  7. SACKS W. Cerebral metabolism of glucose-3-C14, pyruvate-1-C14 and lactate-1-C14 in mental disease. J Appl Physiol. 1961 Jan;16:175–180. doi: 10.1152/jappl.1961.16.1.175. [DOI] [PubMed] [Google Scholar]
  8. SACKS W. Cerebral metabolism of isotopic glucose in normal human subjects. J Appl Physiol. 1957 Jan;10(1):37–44. doi: 10.1152/jappl.1957.10.1.37. [DOI] [PubMed] [Google Scholar]
  9. Stern M. P., Farquhar J. W., Silvers A., Reaven G. M. Insulin delivery rate into plasma in normal and diabetic subjects. J Clin Invest. 1968 Sep;47(9):1947–1957. doi: 10.1172/JCI105884. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Waterhouse C., Baker N., Rostami H. Effect of glucose ingestion on the metabolism of free fatty acids in human subjects. J Lipid Res. 1969 Sep;10(5):487–494. [PubMed] [Google Scholar]
  11. Waterhouse C., Kemperman J. H. Changes in oxidative metabolism with glucose ingestion. J Lab Clin Med. 1966 Aug;68(2):250–264. [PubMed] [Google Scholar]

Articles from Journal of Clinical Investigation are provided here courtesy of American Society for Clinical Investigation

RESOURCES