Table 5.
Multivariate Analyses for Change in Optical Coherence Tomography Central Subfield from Baseline to the 6-Month Study Visit (N=219*)
| N | Baseline Central Subfield Median (um) | Change in Central Subfield from Baseline Median (um, quartiles) | Change in logOCT from Baseline Mean (Standard Deviation) | Central Subfield Reduction ≥1 log step N (%) | Central Subfield Increase ≥1 log step N (%) | Univariate Analysis P value** | Full† and Final‡ Multivariate Analysis P value** | |
|---|---|---|---|---|---|---|---|---|
| Baseline CSF Thickness§ | <0.001 | 0.001 | ||||||
| <300 | 28 | 246 | −2 (−52 to +46) | 0 (0.12) | 7 (25%) | 6 (21%) | ||
| 300-<400 | 75 | 343 | −84 (−128 to −38) | −0.12 (0.11) | 40 (53%) | 1 (1%) | ||
| ≥400 | 116 | 525 | −182 (−304 to −84) | −0.22 (0.19) | 78 (67%) | 2 (2%) | ||
| Baseline Visual Acuity (Snellen Equivalent)§ | <0.001 | <0.001 | ||||||
| ≥20/40 | 38 | 352 | −58 (−101 to −19) | −0.08 (0.10) | 15 (39%) | 2 (5%) | ||
| <20/40-20/80 | 94 | 412 | −90 (−167 to −34) | −0.14 (0.16) | 51 (54%) | 5 (5%) | ||
| <20/80 | 87 | 495 | −159 (−293 to −68) | −0.21 (0.19) | 59 (68%) | 2 (2%) | ||
| Internal Limiting Membrane Removed | 0.02 | 0.003 | ||||||
| No | 75 | 401 | −88 (−167 to +2) | −0.12 (0.18) | 36 (48%) | 5 (7%) | ||
| Yes | 144 | 413 | −106 (−231 to −51) | −0.18 (0.17) | 89 (62%) | 4 (3%) | ||
| Baseline OCT Vitreoretinal Abnormalities, as graded by reading center | 0.03 | 0.006 | ||||||
| No Evidence | 60 | 417 | −85 (−167 to +1) | −0.11 (0.17) | 28 (47%) | 6 (10%) | ||
| Questionable or Definite | 156 | 398 | −104 (−201 to −39) | −0.17 (0.17) | 95 (61%) | 3 (2%) |
13 study participants who missed the 6-month visit, 3 missing central subfield measurement at baseline, and 6 missing central subfield measurement at 6 months are not included
P values are from regression models obtained based on logarithmic transformation of central subfield thickness (“logOCT”).
Includes all factors that were P<0.10 in the univariate models.
Includes factors that remained in the multivariate model after a backward selection process using P<0.01 to stay in the model. (For this analysis, all factors in the full model remained in the final model.)
Continuous/ordinal version of variable used in regression model to obtain P-value
OCT= optical coherence tomography, CSF=central subfield thickness