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Indian Journal of Psychiatry logoLink to Indian Journal of Psychiatry
. 1993 Apr-Jun;35(2):131–134.

EFFECT OF LITHIUM THERAPY ON THYROID FUNCTION: A RETROSPECTIVE STUDY ON INDIAN PATIENTS

AS Srivastava 1,*, PB Behere 2, JK Agrawal 3
PMCID: PMC2978469  PMID: 21743619

SUMMARY

Thirty patients with Bipolar affective disorder who were on Lithium therapy for 6 months to 24 months, were tested for any alteration in their thyroid function. Eight (26.67%) patients had elevated serum TSH level and four (13.33%) patients had decreased serum T4 level than the normal range. Serum T3, although showing a declining trend was found within the normal range in all the patients.

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Selected References

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  1. Bocchetta A., Bernardi F., Burrai C., Pedditzi M., Loviselli A., Velluzzi F., Martino E., Del Zompo M. The course of thyroid abnormalities during lithium treatment: a two-year follow-up study. Acta Psychiatr Scand. 1992 Jul;86(1):38–41. doi: 10.1111/j.1600-0447.1992.tb03222.x. [DOI] [PubMed] [Google Scholar]
  2. Bocchetta A., Bernardi F., Pedditzi M., Loviselli A., Velluzzi F., Martino E., Del Zompo M. Thyroid abnormalities during lithium treatment. Acta Psychiatr Scand. 1991 Mar;83(3):193–198. doi: 10.1111/j.1600-0447.1991.tb05523.x. [DOI] [PubMed] [Google Scholar]
  3. Brownlie B. E., Chambers S. T., Sadler W. A., Donald R. A. Lithium associated thyroid disease--a report of 14 cases of hypothyroidism and 4 cases of thyrotoxicosis. Aust N Z J Med. 1976 Jun;6(3):223–229. doi: 10.1111/j.1445-5994.1976.tb03659.x. [DOI] [PubMed] [Google Scholar]
  4. Cooper T. B., Simpson G. M. Preliminary report of a longitudinal study of the effects of lithium on iodine metabolism. Curr Ther Res Clin Exp. 1969 Oct;11(10):603–608. [PubMed] [Google Scholar]
  5. Crowe M. J., Lloyd G. G., Bloch S., Rosser R. M. Hypothyroidism in patients treated with lithium: a review and two case reports. Psychol Med. 1973 Aug;3(3):337–342. doi: 10.1017/s0033291700049631. [DOI] [PubMed] [Google Scholar]
  6. Emerson C. H., Dysno W. L., Utiger R. D. Serum thyrotropin and thyroxine concentrations in patients recieving lithium carbonate. J Clin Endocrinol Metab. 1973 Feb;36(2):338–346. doi: 10.1210/jcem-36-2-338. [DOI] [PubMed] [Google Scholar]
  7. Hullin R. P., McDonald R., Allsopp M. N. Further report on prophylatic lithium in recurrent affective disorders. Br J Psychiatry. 1975 Mar;126:281–284. doi: 10.1192/bjp.126.3.281. [DOI] [PubMed] [Google Scholar]
  8. Lazarus J. H., John R., Bennie E. H., Chalmers R. J., Crockett G. Lithium therapy and thyroid function: a long-term study. Psychol Med. 1981 Feb;11(1):85–92. doi: 10.1017/s0033291700053307. [DOI] [PubMed] [Google Scholar]
  9. Maarbjerg K., Vestergaard P., Schou M. Changes in serum thyroxine (T4) and serum thyroid stimulating hormone (TSH) during prolonged lithium treatment. Acta Psychiatr Scand. 1987 Feb;75(2):217–221. doi: 10.1111/j.1600-0447.1987.tb02778.x. [DOI] [PubMed] [Google Scholar]
  10. McLarty D. G., O'Boyle J. H., Spencer C. A., Ratcliffe J. G. Effect of lithium on hypothalamic-pituitary-thyroid function in patients with affective disorders. Br Med J. 1975 Sep 13;3(5984):623–626. doi: 10.1136/bmj.3.5984.623. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Myers D. H., Carter R. A., Burns B. H., Armond A., Hussain S. B., Chengapa V. K. A prospective study of the effects of lithium on thyroid function and on the prevalence of antithyroid antibodies. Psychol Med. 1985 Feb;15(1):55–61. doi: 10.1017/s0033291700020924. [DOI] [PubMed] [Google Scholar]
  12. Reus V. I., Gold P., Post R. Lithium-induced thyrotoxicosis. Am J Psychiatry. 1979 May;136(5):724–725. doi: 10.1176/ajp.136.5.724. [DOI] [PubMed] [Google Scholar]
  13. Rosser R. Thyrotoxicosis and lithium. Br J Psychiatry. 1976 Jan;128:61–66. doi: 10.1192/bjp.128.1.61. [DOI] [PubMed] [Google Scholar]
  14. Schou M., Amdisen A., Eskjaer Jensen S., Olsen T. Occurrence of goitre during lithium treatment. Br Med J. 1968 Sep 21;3(5620):710–713. doi: 10.1136/bmj.3.5620.710. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Shopsin B., Blum M., Gershon S. Lithium-induced thyroid disturbance: case report and review. Compr Psychiatry. 1969 May;10(3):215–223. doi: 10.1016/0010-440x(69)90035-2. [DOI] [PubMed] [Google Scholar]

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