Table 2. Fine mapping of the locus for AF on chromosome 4q25 in the discovery sample from MGH.
| Single nucleotide polymorphism |
Position | Minor/ major allele |
Minor allele frequency (%) |
Adjusted OR (95% CI)* |
P Value | |
|---|---|---|---|---|---|---|
| AF | No AF | |||||
| rs17554590 | 111,782,351 | G/C | 1.7 | 2.0 | 0.97 (0.59-1.61) | 0.91 |
| rs2595098 | 111,782,931 | A/T | 4.8 | 7.1 | 0.63 (0.46-0.84) | 2.9×10−3 |
| rs1448818 | 111,789,672 | C/A | 30.1 | 25.7 | 1.24 (1.07-1.44) | 4.7×10−3 |
| rs12498374 | 111,803,868 | T/C | 25.0 | 19.9 | 1.32 (1.12-1.55) | 7.0×10−4 |
| rs1448822 | 111,820,547 | A/G | 36.0 | 30.6 | 1.26 (1.09-1.45) | 1.5×10−3 |
| rs13120244 | 111,823,793 | A/G | 10.0 | 12.4 | 0.83 (0.67-1.03) | 0.09 |
| rs1900827 | 111,843,188 | T/C | 40.0 | 31.2 | 1.41 (1.23-1.62) | 7.8×10−7 |
| rs4371683 | 111,846,216 | A/C | 40.1 | 31.6 | 1.40 (1.22-1.61) | 1.5×10−6 |
| rs17042026 | 111,851,823 | A/G | 26.1 | 16.8 | 1.64 (1.39-1.92) | 2.8×10−9 |
| rs12646859 | 111,854,082 | G/T | 14.1 | 14.7 | 0.99 (0.82-1.19) | 0.89 |
| rs10222783 | 111,854,275 | T/C | 3.6 | 2.3 | 1.56 (1.02-2.37) | 0.04 |
| rs2595085 | 111,856,222 | G/C | 40.2 | 31.8 | 1.40 (1.22-1.60) | 2.0×10−6 |
| rs1448817 | 111,860,502 | G/A | 38.0 | 27.6 | 1.51 (1.31-1.74) | 8.4×10−9 |
| rs11098090 | 111,875,857 | C/T | 14.8 | 14.2 | 1.04 (0.86-1.26) | 0.68 |
| rs4307025 | 111,876,952 | A/T | 37.8 | 27.4 | 1.50 (1.31-1.73) | 1.2×10−8 |
| rs2634071 | 111,888,669 | T/C | 28.9 | 19.2 | 1.60 (1.37-1.87) | 2.0×10−9 |
| rs2723333 | 111,918,540 | A/G | 8.9 | 12.0 | 0.74 (0.59-0.92) | 6.7×10−3 |
| rs1906615 | 111,921,247 | T/G | 30.1 | 20.6 | 1.54 (1.32-1.80) | 2.6×10−8 |
| rs2200733 | 111,929,618 | T/C | 21.5 | 11.7 | 1.80 (1.50-2.15) | 1.2×10−10 |
| rs13143308 | 111,933,868 | T/G | 31.7 | 21.1 | 1.60 (1.38-1.86) | 9.5×10−10 |
| rs13105878 | 111,937,596 | A/C | 7.8 | 10.8 | 0.73 (0.58-0.93) | 9.7×10−3 |
| rs11931959 | 111,939,134 | G/A | 38.2 | 28.5 | 1.47 (1.28-1.69) | 7.8×10−8 |
| rs10033464 | 111,940,210 | T/G | 9.2 | 8.5 | 1.07 (0.84-1.35) | 0.59 |
| rs3855819 | 111,946,612 | G/C | 14.3 | 13.2 | 1.09 (0.90-1.32) | 0.38 |
| rs6533531 | 111,951,414 | G/T | 47.3 | 37.0 | 1.43 (1.24-1.64) | 5.9×10−7 |
| rs3853444 | 111,953,585 | C/T | 29.7 | 30.8 | 0.95 (0.82-1.10) | 0.49 |
| rs17570669 | 111,956,331 | T/A | 7.2 | 8.5 | 0.87 (0.67-1.12) | 0.28 |
| rs13130446 | 111,958,605 | T/C | 49.8 | 49.8 | 1.02 (0.89-1.16) | 0.80 |
| rs10516564 | 111,958,741 | G/A | 29.1 | 30.0 | 0.93 (0.80-1.08) | 0.33 |
| rs3866834 | 111,963,462 | A/G | 33.9 | 34.0 | 1.02 (0.89-1.18) | 0.79 |
| rs4124163 | 111,965,048 | G/A | 3.0 | 5.0 | 0.61 (0.42-0.87) | 6.1×10−3 |
| rs3853445 | 111,980,936 | C/T | 20.3 | 26.2 | 0.71 (0.61-0.84) | 4.1×10−5 |
| rs6838901 | 111,984,764 | C/G | 13.6 | 14.6 | 0.93 (0.77-1.13) | 0.47 |
| rs6838973 | 111,984,944 | T/C | 34.6 | 41.5 | 0.75 (0.66-0.86) | 4.8×10−5 |
Genomic position from NCBI build 36. OR is the odds ratio corresponding to the minor allele.
*
Adjusted for age, sex, and hypertension.