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Proceedings of the National Academy of Sciences of the United States of America logoLink to Proceedings of the National Academy of Sciences of the United States of America
. 1989 Sep;86(18):6835–6837. doi: 10.1073/pnas.86.18.6835

Criteria for the validity of clinical trials of treatments of cohorts of cancer patients based on the Hardin Jones principle.

L Pauling 1, Z S Herman 1
PMCID: PMC297944  PMID: 2780542

Abstract

With the assumption of the validity of the Hardin Jones principle that the death rate of members of a homogeneous cohort of cancer patients is constant, three criteria for the validity of clinical trials of cancer treatments are formulated. These criteria are satisfied by most published clinical trials, but one trial was found to violate all three, rendering the validity of its reported results uncertain.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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