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. 1989 Sep;86(18):7007–7011. doi: 10.1073/pnas.86.18.7007

Expression of major histocompatibility complex class I antigens in rat muscle cultures: the possible developmental role in myogenesis.

H Honda 1, A Rostami 1
PMCID: PMC297981  PMID: 2571148

Abstract

The expression of major histocompatibility complex class I antigens was demonstrated on aneurally cultured rat muscle cells. Myoblasts showed constitutive expression of class I antigens on their cell surfaces. The presence of the antigens was transitory, disappearing as myoblasts fused and differentiated into multinucleate myotubes. Furthermore, antibody against rat class I antigens showed an inhibitory effect on the generation of myotubes during muscle development. Although mature myotubes did not show any detectable levels of class I antigens on their cell surface, soluble factors from concanavalin A-activated spleen cells or interferon gamma could induce the expression of class I antigens on muscle fibers. These results suggest that the expression of class I antigens on muscle cells is not only immunologically modulated but also developmentally regulated and that the antigens may play a role in cell recognition and interactions during the fusion process of myogenesis.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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