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. 1989 Oct;86(19):7341–7345. doi: 10.1073/pnas.86.19.7341

Immunoglobulin enhancer and promoter motifs 5' of the B29 B-cell-specific gene.

G G Hermanson 1, M Briskin 1, D Sigman 1, R Wall 1
PMCID: PMC298057  PMID: 2508087

Abstract

B29 is a B-cell-specific member of the immunoglobulin gene superfamily that is expressed throughout B-cell development beginning with the earliest precursor B cells undergoing immunoglobulin heavy-chain gene segment rearrangements. We have analyzed the region upstream of the B29 gene to identify DNA sequences involved in transcriptional regulation of this gene. The B29 gene lacks a TATA box and transcription is initiated at multiple sites. The B29 gene sequence 5' of these transcription start sites contains six promoter and enhancer motifs known to control immunoglobulin gene transcription. The most notable is a perfect octamer (5'-ATTTGCAT-3'), which binds the Oct-2 B-cell-specific transcription factor and thereby can account for the tissue-specific expression of this gene.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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