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. 1989 Oct;86(19):7520–7521. doi: 10.1073/pnas.86.19.7520

Fruit flies with additional expression of the elongation factor EF-1 alpha live longer.

J C Shepherd 1, U Walldorf 1, P Hug 1, W J Gehring 1
PMCID: PMC298096  PMID: 2508089

Abstract

In Drosophila melanogaster, the decrease in protein synthesis that accompanies aging is preceded by a decrease in elongation factor EF-1 alpha protein and mRNA. Here we show that Drosophila transformed with a P-element vector containing an EF-1 alpha gene under control of hsp70 regulatory sequences have a longer life-span than control flies.

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Selected References

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