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. 1989 Dec;86(24):10011–10014. doi: 10.1073/pnas.86.24.10011

The Huntington disease locus is most likely within 325 kilobases of the chromosome 4p telomere.

N A Doggett 1, J F Cheng 1, C L Smith 1, C R Cantor 1
PMCID: PMC298632  PMID: 2557612

Abstract

The genetic defect responsible for Huntington disease was originally localized near the tip of the short arm of chromosome 4 by genetic linkage to the locus D4S10. Several markers closer to Huntington disease have since been isolated, but these all appear to be proximal to the defect. A physical map that extends from the most distal of these loci, D4S90, to the telomere of chromosome 4 was constructed. This map identifies at least two CpG islands as markers for Huntington disease candidate genes and places the most likely location of the Huntington disease defect remarkably close (within 325 kilobases) to the telomere.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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