The number of trials taken (a), and number of errors made (b) to reach a criterion of six consecutive correct trials in the attentional set-shifting paradigm. Animals from each group performed identical discriminations throughout simple discrimination (SD), compound discrimination (CD) and intra-dimensional shifts 1 and 2 (ID1 and ID2). During the final discrimination animals performed either a third ID shift (ID3) or an extra-dimensional shift (ED). Data are expressed as mean±SEM, n=8. * P<0.05, #P=0.051 different from ID3 (Student's t-test). (c) The mean number of Fos-positive cell counts per mm2 tissue in the mPFC, OFC, ME, IE, LE, PPC and PRh from animals which had performed intra-dimensional shifts (ID3) or animals which had performed EDs. Data are expressed as mean±SEM, n=8. * P<0.05, ** P<0.01 significantly different from ID3 (Student's t-test).