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. 1987 Aug;84(16):5773–5777. doi: 10.1073/pnas.84.16.5773

Pituitary follicular cells produce basic fibroblast growth factor.

N Ferrara, L Schweigerer, G Neufeld, R Mitchell, D Gospodarowicz
PMCID: PMC298945  PMID: 2441393

Abstract

Cultured monolayers of bovine pituitary follicular cells, which transport ions, contain high amounts of mitogenic activity for endothelial cells which, on the basis of gene expression analysis, heparin-Sepharose elution profile, bioassay, immunoblotting, radioimmunoassay, and radioreceptor assay, has been identified as basic fibroblast growth factor (bFGF). These data indicate that follicular cells may be a major source of bFGF in the pituitary gland. Considering that bFGF has been proposed to play a role in paracrine regulation of pituitary hormone secretion, the data also suggest that these cells may exert important local regulatory functions.

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Selected References

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