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. 1987 Aug;84(16):5962–5966. doi: 10.1073/pnas.84.16.5962

Molecular cloning of a brain-specific calcium/calmodulin-dependent protein kinase.

C R Lin, M S Kapiloff, S Durgerian, K Tatemoto, A F Russo, P Hanson, H Schulman, M G Rosenfeld
PMCID: PMC298983  PMID: 3475713

Abstract

A calcium/calmodulin-dependent protein kinase type II (CaM-K) alpha-subunit cDNA has been cloned from rat brain. This enzyme is encoded by a 5.1-kilobase mRNA expressed exclusively in the brain. Hybridization histochemistry reveals that the CaM-K mRNA expression corresponds to the distribution of the immunoreactive alpha-subunit protein, suggesting that the high enzyme levels in specific brain areas reflect regional differences in gene expression. The sequence of CaM-K alpha-subunit cDNA indicates a 478-amino acid (54-kDa) protein with three functional domains. The domain organization suggests a structural model for calcium/calmodulin-dependent and independent states that might subserve short- and long-term responses to transient stimuli.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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