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Indian Journal of Psychiatry logoLink to Indian Journal of Psychiatry
. 1989 Apr-Jun;31(2):139–143.

EFFECT OF IMIPRAMINE AND ECT ON PLATELET MAO ACTIVITY IN DEPRESSIVES

JK Trivedi 1,, RP Singh 2, Narottam Lal 1, PN Viswanathan 3, Sudhir Kumar 4
PMCID: PMC2991675  PMID: 21927372

SUMMARY

Platelet monoamine Oxidase (MAO) activity was estimated in 30 depressed patients treated with Imipramine or EGT over a period of 5 weeks and pretreatment and post treatment values were compared. Imipramine and ECT caused significant reduction of platelet MAO, which after 7 days washout period comes to the pretreatment level while subjects clinical status l remained unchanged. The percentage blockade in platelet MAO values by Imipramine and ECT was 51.40±13.43 and 34.73±24.27 respectively.

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