Table 1.
Relative rate tests with shh partial enhancer sequences.*
| ar-D/SFPE1 | ||||||
|---|---|---|---|---|---|---|
| Ingroup | Outgroup | Identical Sites | Divergent Sites | χ2 (1° freedom) | Probability | |
| Mouse | Chick | Lme | 122 | 8 | 27.52 | 0.00000 |
| Human | Chck | Lme | 126 | 1 | 17.79 | 0.00002 |
| Opo | Chick | Lme | 144 | 1 | 9.97 | 0.00159 |
| Lme | Chick | Danio | 129 | 9 | 1.33 | 0.24821 |
| ar-A | ||||||
| Ingroup | Outgroup | Identical Sites | Divergent Sites | χ2 (1° freedom) | Probability | |
| Mouse | Chick | Lme | 98 | 9 | 8.17 | 0.00427 |
| Human | Chick | Lme | 98 | 4 | 12.80 | 0.00035 |
| Opo | Chick | Lme | 105 | 2 | 3.56 | 0.05935 |
| Lme | Chick | Danio | 103 | 5 | 2.00 | 0.15730 |
| ar-C | ||||||
| Ingroup | Outgroup | Identical Sites | Divergent Sites | χ2 (1° freedom) | Probability | |
| Mouse | Chick | Lme | 65 | 1 | 13.50 | 0.00024 |
| Human | Chick | Lme | 72 | 1 | 9.31 | 0.00228 |
| Opo | Chick | Lme | 73 | 2 | 6.25 | 0.01242 |
| Lme | Chick | Dano | 62 | 3 | 1.60 | 0.20590 |
*The equality of evolutionary rate between ingroup sequences is tested using the outgroup sequence. The χ2 test statistic and probability values are listed. Enhancer alignments are shown in Additional file 4. Species generic name abbreviation Lme: Latimeria menadoensis, Danio: Danio rerio (zebrafish), Opo: Monodelphis domestica (opossum).