Skip to main content
NCBI home page
Rare Tumors logoLink to Rare Tumors
. 2010 Mar 31;2(1):e5. doi: 10.4081/rt.2010.e5

A case of esophageal adenocarcinoma arising from the ectopic gastric mucosa in the thoracic esophagus

Shuji Komori 1, Shinji Osada 1, Yoshihiro Tanaka 1, Takao Takahashi 1, Narutoshi Nagao 1, Kazuya Yamaguchi 1, Nami Asano 2, Kazuhiro Yoshida 1
PMCID: PMC2994492  PMID: 21139950

Abstract

A 75-year old man was detected with a pediculate tumor in the upper esophagus. A biopsy determined that it was an adenocarcinoma. A subtotal esophagectomy with dissection of three-fields of lymph nodes was selected. The pathological study revealed it to be an esophageal adenocarcinoma arising from ectopic gastric mucosa of the fundus of the stomach. His post-operative course was uneventful and without sign of recurrence for 3.5 years.

Key words: esophageal adenocarcinoma, ectopic gastric mucosa, chemotherapy.

Introduction

Esophageal adenocarcinomas arising from ectopic gastric mucosa (EAEGM) have been reported in only 26 cases worldwide, therefore therapy for this condition is still inconsistent. The available therapeutic strategies for surgical treatment, chemotherapy and/or radiation will be discussed from experience with the present case, and in reference to past reported cases. This is the first report to discuss the clinical features and treatment for EAEGM.

Case Report

A 75-year old man underwent a medical examination without any complications. Since an upper gastrointestinal X-ray showed a simple shaped tumor, 20 mm in size (Figure 1a), detailed studies were selected. On laboratory blood examination, no abnormal data were found except for slight anemia and a high value of squamous cell carcinoma-related antigen, 1.3 ng/mL (normal range; <1.5 ng/mL). An upper gastrointestinal endoscopy detected a pediculate tumor, 25 mm in size, with easy bleeding in the upper thoracic esophagus (invasive level; muscularis propria) (cT2) (Figure 1b), and pathological findings from a biopsied specimen revealed a moderately differentiated tubular adenocarcinoma. With chest and abdominal computed tomography (CT), a primary pediculate tumor, 30×20 mm in size, with regional lymphnode swelling (N1) was noted without any metastasis or direct invasion to other organs (M0). According to the UICC 6th edition staging system, the tumor was indicated as cStage IIB, and a subtotal esophagectomy with lymph-node clearing was performed in April, 2006. On removal, a type I tumor, 35×22 mm in size, was observed on the esophagus, and it stained negative with lugol solution (Figure 2). In addition, the esophageal mucosa surrounding the tumor was also negative for lugol solution, suggesting that the tumor arose from the ectopic mucosa. The pathological study demonstrated the presence of a tubular papillary and solid type EAEGM (pStage: I, invasion level: mucosa, lymphatic duct invasion: not detected, vessel invasion: not detected) (Figure 3), and lymph node metastasis was not noted. The patient is currently in good health without any problems.

Figure 1.

Figure 1

Open in a new tab

Upper gastrointestinal X-ray and endoscopic examination. Barium esophagogram (a) (arrow) and upper gastrointestinal endoscopy (b) showed a pediculate tumor, 20 mm in size, which was detected in the upper thoracic esophagus.

Figure 2.

Figure 2

Open in a new tab

Removed specimen of subtotal esophagectomy. The type I tumor, 35 × 22 mm in size, was detected in the specimen (arrow head). The tumor was round shaped and was negative for lugol solution staining, with the negative staining extending 5 cm distant from the oral margin (arrows).

Figure 3.

Figure 3

Open in a new tab

Pathological findings. Tubular, papillary and solid adenocarcinoma were localized within the tumor (a and b). In the epithelium around the tumor, mucosa similar to fundic gland mucosa extended from the tumor (a and c). H & E stain, (a) ×40, (b and c) ×100 magnification.

Discussion

Primary esophageal adenocarcinomas that match the following diagnostic criteria represent 0.76% of all the cases of carcinoma of the esophagus or cardia; i) a tumor localized in the esophagus from the cricoid cartilage to the cardiac orifice; ii) a tumor arising from the esophageal glands; iii) a tumor that has tissues of the glands, and where there are lesions of the carcinoma discharging mucus on the inside of the tumor; iv) existence of normal squamous epithelium in the anal side of the tumor, or a tumor that exists in an area apart from the cardiac orifice; v) no primary cancerous lesions in the other organs.1,2 Because the incidence of ectopic gastric mucosa has been detected in only 4.0% of males and 2.9% of females,3 carcinogenesis at this site is observed quite rarely, with 26 cases reported worldwide as shown in Table 1.4–25 The age of these patients ranged from 37 to 85 years, and the tumor size was between 1.9 and 7.0 cm (mean; 3.9 cm). The nature of invasion into surrounding tissues was found to be to the submucosal level in 9 cases, muscular invasion in 4 cases and advanced invasion in 9 cases, with 3 cases unknown. If the degree of layer invasion and tumor size are compared, the average tumor size was 3.4 cm in submucosal invasion, 4.3 cm in advanced invasion and 4.5 cm in muscular invasion, suggesting that the tumor size (width of growth) might be associated with the degree of layer invasion (invasive level of tumor). However, the prognosis was not exactly indicated by tumor size, because in patients with big tumors, such as 5 cm or 6.5 cm, there may be no signs of recurrence, whereas tumors as small as 2 or 3 cm could lead to recurrence. Focusing on the nature of the layer invasion to estimate the most favorable therapeutic strategy in submucosal invasion cases, esophagectomy was an appropriate radical treatment, but not partial resection, because local resection alone was found to lead to local recurrence. In muscular invasion cases, one of 2 cases of esophagectomy without additional therapy led to recurrence, and a case treated with radiotherapy (RT) and chemoradiotherapy (CRT) showed a relatively good prognosis. In advanced cases, with the exception of one unknown case without detailed data, esophagectomy without additional therapy led to a poor prognosis for 3 cases in 4, and one case remains alive but is still under short-term observation. In contrast, one esophagectomy case combined with RT showed a good outcome. In addition, esophagectomy combined with radiation or chemo-radiation therapy might result in a favorable outcome, suggesting that additional treatment beyond the initial operation is critical. In the present case, since there was no tumor invasion into the muscular layer, no adjuvant treatment was required and no signs of recurrence have been observed.

Table 1. Twenty-six cases of esophageal adenocarcinoma arising from the ectopic gastric mucosa.

Author and year Age/sex Size(cm) Histological type Depth of invasion Treatment Prognosis
1. Carrie (1950)6 64M 3 Adenoca. Muscularis propria Partial esophagectomy Alive (over one year; unknown in detail)
2. Davis (1969)6) 68M 1.8×7 Mucinous adenoca. Submucosa RT+esophagectomy Alive (7 months; unknown in detail)
3. Sakamoto (1970)7 64M 2.5×1.7 Papillary adenoca. Muscularis propria RT+esophagectomy and inguinal skin meta) Dead (37 months; cervical
4. Clemente (1974)8 53M 2.5×2×2 Intestinal type. Adventitia Laryngectomy + esophagectomy Cervical recurrence
5. Danoff (1978)4 43M 6 Poorly diff adenoca. Adventitia RT Dead (2 months)
6. Kamiya (1983)9 58M 5×3 Moderately diff adenoca. Adventitia Pharyngolaryngectomy+esophagectomy Dead (7 months; pneumonia)
7. Schmidt 1 (1985)10 37M Not mentioned. Adenoca. Adventitia Esophagectomy Alive (4 months; unknown in detail)
8. Schmidt 2 (1985)10 54M 3 Adenoca. Submucosa Partial esophagectomy Dead (12 months; local recurrence)
9. Endo (1986)11 73M Not mentioned Adenosquamous ca. Unknown Not resected Dead (12 months)
10. Christensen 1 (1987)12 52M 6×5.5×2 Poorly diff adenoca. Muscularis propria Esophagectomy Dead suspected (Abdominal meta)
11. Christensen 2 (1987)12 50M 4×3.5×1.5 Moderately diff adenoca. Adventitia Esophagogastrectomy Not mentioned
12. Ishii (1991) (13) 66M 5×4.5×3 Well diff adenoca. Submucosa Esophagectomy No rec (20 months)
13. Kubota (1993)14 58M Not mentioned. Papillary adenoca. Adventitia CRT only Dead (12 months; lung meta)
14. Takagi Y (1994)15 85M 6.8×3 Moderately diff adenoca. Adventitia Transhiatal esophagectomy Not mentioned
15. Takagi A (1995)16 70M 1.9×1.6 Well diff adenoca. Submucosa Esophagectomy Not mentioned
16. Sperling (1995)17 79M 2 Poorly diff adenoca. unknown RT Not mentioned
17. Kammori (1996)18 74F 2×1.5×0.7 Well diff adenoca. Submucosa Mucosal resection No rec. (unknown in detail)
18. Pai (1997)19 60M 3.5×6.5 Moderately diff adenoca. Muscularis propria Esophagectomy+CRT Alive (30 months; unknown in detail)
19. Berkelhammer (1997)20 71M Not mentioned Moderately diff adenoca Submucosa Esophagectomy No rec. (2 years)
20. Yamamoto (1997)21 90F Not Adenoca. unknown Transhiatal esophagectomy Not mentioned
21. Lauwers (1998)22 57M 2×4 Moderately diff adenoca. Adventitia Esophagectomy+RT Alive (8 months; unknown in detail)
22. Noguchi (2001)23 73M 2.5×2 Well diff adenoca. Submucosa Esophagectomy No rec (5 years)
23. Kagawa (2001)24 51M 2×2 Moderately diff adenoca. Adventitia Esophagectomy Dead (11 months; lung meta)
24. Abe (2004)25 50M 2.5×1.5 Well diff adenoca. Submucosa Esophagectomy No rec (unknown in detail)
25. Alrawi (2004)5 60M 3.2×3 Moderately diff adenoca. Submucosa Partial esophagectomy+CRT No rec (6 years)
26. Our case (2006) 75M 3.5×2.2 Adenoca. Mucosa Esophagectomy No rec (42 months)
Open in a new tab

Adenoca, adenocarcinoma; rec, recurrence; meta, metastasis.

The rate of lymph node metastases was found to be relatively high in the esophagus, with around 30% of cases showing submucosal invasion, compared to 19% in the stomach.26 Additionally, distant metastasis has been noted frequently due to the anatomical characteristic of the esophagus developing a strong lymphatic network,27 indicating the importance of aggressive lymph node resection. In fact, complete surgical resection represents a first-line treatment for esophageal adenocarcinomas, such as Barrett's esophageal adenocarcinoma.28 In addition, in East Asia, the combined drug TS-1 (tegafur/gimeracil/oteracil potassium), an oral 5-FU drug, is widely accepted as a chemotherapeutic agent due to its high response rate; 47% in single use and over 70% when used in combination with other chemotherapeutic agents.29,30 In contrast, because TS-1 is not commonly used in North America and Europe, a combination chemotherapy based on infused 5-FU is widely selected as a standard; infused 5-FU and cisplatin or the addition of a third drug (anthracyclines; epirubicin).31,32 The response rate has been reported as 49–56% against locally advanced gastric cancer.33,34 In conclusion, radical surgical treatment with adjuvant chemotherapy should be considered for advanced EAEGM.

References

  • 1.Nakayama T, Yanagisawa F, Suzuki K. Primary adenocarcinoma of esophagus. Japan Journal of Cancer Clinics. 1964;10:8–16. [PubMed] [Google Scholar]
  • 2.Raphael HA, Ellis FH, Jr, Dockerty MB. Primary adenocarcinoma of the esophagus: 18-years review and review of literature. Ann Surg. 1996;164:785–96. doi: 10.1097/00000658-196611000-00002. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 3.Nakajima H, Munakata A, Yoshida Y. Endoscopic diagnosis and significance of islet patch. Gastroenterological Endoscopy. 1991;33:1357–62. [Google Scholar]
  • 4.Danoff B, Cooper J, Klein M. Primary adenocarcinoma of the upper oesophagus. Clin Radiol. 1987;29:519–22. doi: 10.1016/s0009-9260(78)80042-7. [DOI] [PubMed] [Google Scholar]
  • 5.Alrawi SJ, Winston J, Tan D, et al. Primary adenocarcinoma of cervical esophagus. J Exp Clin Cancer Res. 2005;24:325–30. [PubMed] [Google Scholar]
  • 6.Davis WM, Goodwin MN, Jr, Black HC, Jr, Hawk JC. Polypoid adenocarcinoma of the cervical esophagus. Arch Pathol. 1969;88:367–70. [PubMed] [Google Scholar]
  • 7.Sakamoto G, Nakamura K, Saito M, Sugahara T. Primary adenocarcinoma arising from heterotopic gastric glands of esophagus. Japanese J Cancer Clinics. 1970;16:1105–10. [PubMed] [Google Scholar]
  • 8.Clemente C. Un caso di adenocarcinoma del terzo superior dell esophago insorto su etropia gastric. Tumori. 1974;60:17–24. doi: 10.1177/030089167406000102. [DOI] [PubMed] [Google Scholar]
  • 9.Kamiya J, Ishigure H, Akita M. A case of primary adenocarcinoma of the cervical esophagus arising from ectopic gastric mucosa. Japanese J Gastroenterol Surgery. 1989;16:1808–11. [Google Scholar]
  • 10.Schmidt H, Riddel R. Adenokarzinoma in heterotoper magenschleimhaut des proximaen ösophagus. Leber Magen Dram. 1985;15:144–7. [PubMed] [Google Scholar]
  • 11.Endo T, Tanaka Y. The study of the patient suffered from the ectopic gastric mucosa with interesting endoscopic findings and unique course. Gastroenterol Endoscopy. 1986;28:3274–3274. [Google Scholar]
  • 12.Christensen WN, Sternberg SS. Adenocarcinoma of the upper esophagus arising in ectopic gastric mucosa. Two case reports and review of the literature. Am J Surg Pathol. 1987;11:397–402. doi: 10.1097/00000478-198705000-00009. [DOI] [PubMed] [Google Scholar]
  • 13.Ishii K, Ota H, Nakayama J, et al. Adenocarcinoma of the cervical oesophagus arising from ectopic gastric mucosa. Virchow Arch A Pathol Anat Histopathol. 1991;419:159–64. doi: 10.1007/BF01600231. [DOI] [PubMed] [Google Scholar]
  • 14.Kubota S, Yamaguchi H, Shirao K. A case of adenocarcinima of the cervical esophagus arising from heterotopic gastric mucosa. Gastrointest Endosc. 1993;5:1255–60. [Google Scholar]
  • 15.Takagi Y, Sato S, Kimura K. A case of primary intra-thoracic esophageal adenocarcinoma in ectopic gastric mucosa in an elderly patient. J Jpn Surg Association. 1994;55:390–4. [Google Scholar]
  • 16.Takagi A, Ema Y, Horii S, et al. Early adenocarcinoma arising from ectopic gastric mucosa in the cervical esophagus. Gastrointest Endosc. 1995;41:167–70. doi: 10.1016/s0016-5107(05)80605-4. [DOI] [PubMed] [Google Scholar]
  • 17.Sperling RM, Grendell JH. Adenocarcinoma arising in an inlet patch of the esophagus. Am J Gastroenterol. 1995;90:1500–3. [PubMed] [Google Scholar]
  • 18.Kammori M, Ogawa T, Hashimoto M, et al. A case of early esophageal adenocarcinoma developed from islet patch of gastric mucosa in the cervical esophagus. Jpn J Gastroenterol Surg. 1996;29:717–21. [Google Scholar]
  • 19.Pai S, Deshpande R, Naresh KN. Adenocarcinoma of cervical esophagus arising in aberrant gastric mucosa. Indian J Gastroenterol. 1997;16:157–8. [PubMed] [Google Scholar]
  • 20.Berkelhammer C, Bhagavan M, Templeton A. Gastric inlet patch containing submucosally infiltrating adenocarcinoma. J Clin Gastroenterol. 1997;25:678–81. doi: 10.1097/00004836-199712000-00025. [DOI] [PubMed] [Google Scholar]
  • 21.Yamamoto S, Habu N, Toriumi Y. A case of primary upper esophageal adenocarcinoma in super high age arising from ectopic gastric mucosa. Jpn Gastroenterol Surg. 1997;30:1431–1431. [Google Scholar]
  • 22.Lauwers GY, Scott GV, Vauthey JN. Adenocarcinoma of the upper esophagus arising in cervical ectopic gastric mucosa. Dig Dis Sci. 1998;43:901–7. doi: 10.1023/a:1018855223225. [DOI] [PubMed] [Google Scholar]
  • 23.Noguchi T, Takeno S, Takahashi Y, et al. Primary adenocarcinoma of the cervical esophagus arising from heterotopic gastric mucosa. J Gastroenterol. 2001;36:704–9. doi: 10.1007/s005350170035. [DOI] [PubMed] [Google Scholar]
  • 24.Kagawa N, Fukuda Y, Ishimoto T, et al. A case of esophageal adenocarcinoma arising from ectopic gastric mucosa in the cervico-thoracic esophagus. Jpn J Surg Association. 2004;65:2637–41. [Google Scholar]
  • 25.Abe T, Hosokawa M, Kusumi T, et al. Adenocarcinoma arising from ectopic gastric mucosa in the cervical esophagus. Am J Clin Oncol. 2004;27:644–5. doi: 10.1097/01.coc.0000147808.63442.b5. [DOI] [PubMed] [Google Scholar]
  • 26.An JY, Baik YH, Choi MG. Predictive factors for lymph node metastasis in early gastric cancer with submucosal invasion: Analysis of a single institutional experience. Ann Surg. 2007;246:749–53. doi: 10.1097/SLA.0b013e31811f3fb7. [DOI] [PubMed] [Google Scholar]
  • 27.Sjoerd ML, Fiebo JWK, Johannes BR. Prognostic factors in adenocarcinoma of the esophagus or gastroesophageal Junction. J Clin Oncol. 2006;24:4347–55. doi: 10.1200/JCO.2005.04.9445. [DOI] [PubMed] [Google Scholar]
  • 28.Alexiou C, Khan OA, Black E. Survival after esophageal resection for carcinoma: the importance of the histologic cell type. Ann Thorac Surg. 2006;82:1073–7. doi: 10.1016/j.athoracsur.2006.03.012. [DOI] [PubMed] [Google Scholar]
  • 29.Sakuramoto S, Sasako M, Yamaguchi T. Adjuvant chemotherapy for gastric cancer S-1, an oral fluoropyrimidine. N Engl J Med. 2007;357:1810–20. doi: 10.1056/NEJMoa072252. [DOI] [PubMed] [Google Scholar]
  • 30.Koizumi W. Phase I/II study of S-1 combined with cisplatin in patients with advanced gastric cancer. Br J Cancer. 2003;89:2207–12. doi: 10.1038/sj.bjc.6601413. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 31.Cunningham D, Allum WH, Stenning SP, et al. Perioperative chemotherapy versus surgery alone for resectable gastroesophageal cancer. N Engl J Med. 2006;355:11–20. doi: 10.1056/NEJMoa055531. [DOI] [PubMed] [Google Scholar]
  • 32.Wagner AD, Grothe W, Haerting J, et al. Chemotherapy in advanced gastric cancer: a systematic review and meta-analysis based on aggregate data. J Clin Oncol. 2006;24:2903–9. doi: 10.1200/JCO.2005.05.0245. [DOI] [PubMed] [Google Scholar]
  • 33.Ross P, Nicolson M, Cunningham D, et al. Prospective randomized trial comparing mitomycin, cisplatin, and protracted venous-infusion fluorouracil (PVI 5-FU) with epirubicin, cisplatin, and PVI 5-FU in advanced esophagogastric cancer. J Clin Oncol. 2002;20:1996–2004. doi: 10.1200/JCO.2002.08.105. [DOI] [PubMed] [Google Scholar]
  • 34.Webb A, Cunningham D, Scarffe JH, et al. Randomized trial comparing epirubicin, cisplatin, and fluorouracil versus fluorouracil, doxorubicin, and methotrexate in advanced esophagogastric cancer. J Clin Oncol. 1997;15:261–7. doi: 10.1200/JCO.1997.15.1.261. [DOI] [PubMed] [Google Scholar]

Articles from Rare Tumors are provided here courtesy of SAGE Publications

RESOURCES