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. 1987 Nov;84(22):8006–8010. doi: 10.1073/pnas.84.22.8006

Genetic linkage map of human chromosome 7 with 63 DNA markers.

D Barker 1, P Green 1, R Knowlton 1, J Schumm 1, E Lander 1, A Oliphant 1, H Willard 1, G Akots 1, V Brown 1, T Gravius 1, et al.
PMCID: PMC299465  PMID: 2891136

Abstract

High-density genetic maps of individual human chromosomes will permit accurate localization of disease-associated genes and provide signposts that will be useful in the construction of physical maps. We have constructed a genetic map of chromosome 7 with 63 polymorphic DNA markers by using segregation data from 23 three-generation families and recently developed multilocus linkage-analysis techniques. The map spans 250 centimorgans in females and 170 centimorgans in males, with much of the difference being concentrated in a few intervals. The density and informativeness of the markers are such that there is a high probability of detecting linkage to any disease gene on this chromosome for which 20 phase-known meioses are available.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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