Abstract
Courtship behavior in Drosophila melanogaster males is an innate behavior pattern. Whether or not a fly will display male courtship behavior is governed by the action of a set of regulatory genes that control all aspects of somatic sexual differentiation. The wild-type function of one of these regulatory genes, transformer-2 (tra-2), is necessary for female sexual differentiation; in the absence of tra-2+ function XX individuals differentiate as males. A temperature-sensitive tra-2 allele has been used to investigate, by means of temperature shifts, when and how male courtship behavior is specified during development. The removal of tra-2ts function in the adult (by a shift of the tra-2ts mutant flies to the restrictive temperature) can lead to the appearance of male courtship behavior in flies that otherwise would not display these behaviors. These experiments suggest that the regulatory hierarchy controlling sexual differentiation is functioning in the adult central nervous system. More importantly, these results suggest that the adult central nervous system has some functional plasticity with respect to the innate behavioral pattern of male courtship and is maintained in a particular state of differentiation by the active control of gene expression in the adult.
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- Arnold A. P. Sexual differences in the brain. Am Sci. 1980 Mar-Apr;68(2):165–173. [PubMed] [Google Scholar]
- Baker B. S., Belote J. M. Sex determination and dosage compensation in Drosophila melanogaster. Annu Rev Genet. 1983;17:345–393. doi: 10.1146/annurev.ge.17.120183.002021. [DOI] [PubMed] [Google Scholar]
- Baker B. S., Ridge K. A. Sex and the single cell. I. On the action of major loci affecting sex determination in Drosophila melanogaster. Genetics. 1980 Feb;94(2):383–423. doi: 10.1093/genetics/94.2.383. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Belote J. M., Baker B. S. Sex determination in Drosophila melanogaster: analysis of transformer-2, a sex-transforming locus. Proc Natl Acad Sci U S A. 1982 Mar;79(5):1568–1572. doi: 10.1073/pnas.79.5.1568. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Belote J. M., Handler A. M., Wolfner M. F., Livak K. J., Baker B. S. Sex-specific regulation of yolk protein gene expression in Drosophila. Cell. 1985 Feb;40(2):339–348. doi: 10.1016/0092-8674(85)90148-5. [DOI] [PubMed] [Google Scholar]
- Bownes M., Nöthiger R. Sex determining genes and vitellogenin synthesis in Drosophila melanogaster. Mol Gen Genet. 1981;182(2):222–228. doi: 10.1007/BF00269661. [DOI] [PubMed] [Google Scholar]
- Breedlove S. M. Cellular analyses of hormone influence on motoneuronal development and function. J Neurobiol. 1986 May;17(3):157–176. doi: 10.1002/neu.480170304. [DOI] [PubMed] [Google Scholar]
- Cook R. 'Lesbian' phenotype of Drosophila melanogaster? Nature. 1975 Mar 20;254(5497):241–242. doi: 10.1038/254241a0. [DOI] [PubMed] [Google Scholar]
- DeVoogd T. J. Steroid interactions with structure and function of avian song control regions. J Neurobiol. 1986 May;17(3):177–201. doi: 10.1002/neu.480170305. [DOI] [PubMed] [Google Scholar]
- Gailey D. A., Jackson F. R., Siegel R. W. Conditioning Mutations in DROSOPHILA MELANOGASTER Affect an Experience-Dependent Behavioral Modification in Courting Males. Genetics. 1984 Apr;106(4):613–623. doi: 10.1093/genetics/106.4.613. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Gailey D. A., Jackson F. R., Siegel R. W. Male courtship in Drosophila: the conditioned response to immature males and its genetic control. Genetics. 1982 Dec;102(4):771–782. doi: 10.1093/genetics/102.4.771. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hall J. C. Control of male reproductive behavior by the central nervous system of Drosophila: dissection of a courtship pathway by genetic mosaics. Genetics. 1979 Jun;92(2):437–457. doi: 10.1093/genetics/92.2.437. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Herndon W. A., Emans J. B., Micheli L. J., Hall J. E. Combined anterior and posterior fusion for Scheuermann's kyphosis. Spine (Phila Pa 1976) 1981 Mar-Apr;6(2):125–130. doi: 10.1097/00007632-198103000-00003. [DOI] [PubMed] [Google Scholar]
- Hotta Y., Benzer S. Courtship in Drosophila mosaics: sex-specific foci for sequential action patterns. Proc Natl Acad Sci U S A. 1976 Nov;73(11):4154–4158. doi: 10.1073/pnas.73.11.4154. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Levine R. B. Changes in neuronal circuits during insect metamorphosis. J Exp Biol. 1984 Sep;112:27–44. doi: 10.1242/jeb.112.1.27. [DOI] [PubMed] [Google Scholar]
- Levine R. B., Truman J. W. Dendritic reorganization of abdominal motoneurons during metamorphosis of the moth, Manduca sexta. J Neurosci. 1985 Sep;5(9):2424–2431. doi: 10.1523/JNEUROSCI.05-09-02424.1985. [DOI] [PMC free article] [PubMed] [Google Scholar]
- McRobert S. P., Tompkins L. The effect of transformer, doublesex and intersex mutations on the sexual behavior of Drosophila melanogaster. Genetics. 1985 Sep;111(1):89–96. doi: 10.1093/genetics/111.1.89. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Ota T., Fukunaga A., Kawabe M., Oishi K. Interactions between sex-transformation mutants of Drosophila melanogaster. I. Hemolymph vitellogenins and gonad morphology. Genetics. 1981 Nov-Dec;99(3-4):429–441. doi: 10.1093/genetics/99.3-4.429. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Postlethwait J. H., Bownes M., Jowett T. Sexual phenotype and vitellogenin synthesis in Drosophila melanogaster. Dev Biol. 1980 Oct;79(2):379–387. doi: 10.1016/0012-1606(80)90123-2. [DOI] [PubMed] [Google Scholar]
- Siegel R. W., Hall J. C. Conditioned responses in courtship behavior of normal and mutant Drosophila. Proc Natl Acad Sci U S A. 1979 Jul;76(7):3430–3434. doi: 10.1073/pnas.76.7.3430. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Siegel R. W., Hall J. C., Gailey D. A., Kyriacou C. P. Genetic elements of courtship in Drosophila: mosaics and learning mutants. Behav Genet. 1984 Sep;14(5):383–410. doi: 10.1007/BF01065442. [DOI] [PubMed] [Google Scholar]
- Spieth H. T. Courtship behavior in Drosophila. Annu Rev Entomol. 1974;19:385–405. doi: 10.1146/annurev.en.19.010174.002125. [DOI] [PubMed] [Google Scholar]
- Sturtevant A H. A Gene in Drosophila Melanogaster That Transforms Females into Males. Genetics. 1945 May;30(3):297–299. doi: 10.1093/genetics/30.3.297. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Technau G. M. Fiber number in the mushroom bodies of adult Drosophila melanogaster depends on age, sex and experience. J Neurogenet. 1984 Apr;1(2):113–126. doi: 10.3109/01677068409107077. [DOI] [PubMed] [Google Scholar]
- Technau G., Heisenberg M. Neural reorganization during metamorphosis of the corpora pedunculata in Drosophila melanogaster. Nature. 1982 Feb 4;295(5848):405–407. doi: 10.1038/295405a0. [DOI] [PubMed] [Google Scholar]
- Tompkins L. Genetic analysis of sex appeal in Drosophila. Behav Genet. 1984 Sep;14(5):411–440. doi: 10.1007/BF01065443. [DOI] [PubMed] [Google Scholar]
- White K., Kankel D. R. Patterns of cell division and cell movement in the formation of the imaginal nervous system in Drosophila melanogaster. Dev Biol. 1978 Aug;65(2):296–321. doi: 10.1016/0012-1606(78)90029-5. [DOI] [PubMed] [Google Scholar]
- Wieschaus E., Nöthiger R. The role of the transformer genes in the development of genitalia and analia of Drosophila melanogaster. Dev Biol. 1982 Apr;90(2):320–334. doi: 10.1016/0012-1606(82)90381-5. [DOI] [PubMed] [Google Scholar]