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. 1987 Dec;84(23):8712–8715. doi: 10.1073/pnas.84.23.8712

Grafted noradrenergic neurons suppress seizure development in kindling-induced epilepsy.

D I Barry 1, I Kikvadze 1, P Brundin 1, T G Bolwig 1, A Björklund 1, O Lindvall 1
PMCID: PMC299616  PMID: 3120197

Abstract

Norepinephrine-rich cell suspensions, prepared from the locus coeruleus region of rat fetuses, were grafted bilaterally into the hippocampus of rats made hypersensitive to hippocampal kindling by a neurotoxic lesion of the central catecholamine system. The animals with grafts showed a marked suppression of the onset and progression of kindling-induced epilepsy, and this effect was correlated with the degree of graft-derived noradrenergic innervation of the host hippocampal formation. We conclude that grafted neurons can modulate the excitability of epileptic brain regions.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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