Skip to main content
PMC home page
Proceedings of the National Academy of Sciences of the United States of America logoLink to Proceedings of the National Academy of Sciences of the United States of America
. 1964 Jun;51(6):1151–1158. doi: 10.1073/pnas.51.6.1151

SELECTIVE INHIBITION OF SYNTHESIS OF RIBOSOMAL RNA IN ESCHERICHIA COLI BY LEVORPHANOL*

Eric J Simon 1,2,3,†, Dina Van Praag 1,2,3
PMCID: PMC300228  PMID: 14215637

Full text

PDF

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Britten R. J., Roberts R. B. High-Resolution Density Gradient Sedimentation Analysis. Science. 1960 Jan 1;131(3392):32–33. doi: 10.1126/science.131.3392.32. [DOI] [PubMed] [Google Scholar]
  2. FRANKLIN R. M. THE INHIBITION OF RIBONUCLEIC ACID SYNTHESIS IN MAMMALIAN CELLS BY ACTINOMYCIN D. Biochim Biophys Acta. 1963 Aug 20;72:555–565. [PubMed] [Google Scholar]
  3. FURTH J. J., HURWITZ J., KRUG R., ALEXANDER M. The incorporation of adenylic and cytidylic acids into ribonucleic acid. J Biol Chem. 1961 Dec;236:3317–3322. [PubMed] [Google Scholar]
  4. GIACOMONI D., SPIEGELMAN S. Origin and biologic individuality of the genetic dictionary. Science. 1962 Dec 21;138(3547):1328–1331. doi: 10.1126/science.138.3547.1328. [DOI] [PubMed] [Google Scholar]
  5. GOLD M., HURWITZ J., ANDERS M. The enzymatic methylation of RNA and DNA. Biochem Biophys Res Commun. 1963 Apr 23;11:107–114. doi: 10.1016/0006-291x(63)90075-5. [DOI] [PubMed] [Google Scholar]
  6. GOODMAN H. M., RICH A. Formation of a DNA-soluble RNA hybrid and its relation to the origin, evolution, and degeneracy of soluble RNA. Proc Natl Acad Sci U S A. 1962 Dec 15;48:2101–2109. doi: 10.1073/pnas.48.12.2101. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. GROS F., HIATT H., GILBERT W., KURLAND C. G., RISEBROUGH R. W., WATSON J. D. Unstable ribonucleic acid revealed by pulse labelling of Escherichia coli. Nature. 1961 May 13;190:581–585. doi: 10.1038/190581a0. [DOI] [PubMed] [Google Scholar]
  8. HAYASHI M., SPIEGELMAN S. The selective synthesis of informational RNA in bacteria. Proc Natl Acad Sci U S A. 1961 Oct 15;47:1564–1580. doi: 10.1073/pnas.47.10.1564. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. HURWITZ J., FURTH J. J., MALAMY M., ALEXANDER M. The role of deoxyribonucleic acid in ribonucleic acid synthesis. III. The inhibition of the enzymatic synthesis of ribonucleic acid and deoxyribonucleic acid by actinomycin D and proflavin. Proc Natl Acad Sci U S A. 1962 Jul 15;48:1222–1230. doi: 10.1073/pnas.48.7.1222. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. JACOB F., MONOD J. Genetic regulatory mechanisms in the synthesis of proteins. J Mol Biol. 1961 Jun;3:318–356. doi: 10.1016/s0022-2836(61)80072-7. [DOI] [PubMed] [Google Scholar]
  11. LEDERBERG J. The beta-d-galactosidase of Escherichia coli, strain K-12. J Bacteriol. 1950 Oct;60(4):381–392. doi: 10.1128/jb.60.4.381-392.1950. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. MANDEL L. R., BOREK E. Variability in the structure of ribonucleic acid. Biochem Biophys Res Commun. 1961 Jan 25;4:14–18. doi: 10.1016/0006-291x(61)90246-7. [DOI] [PubMed] [Google Scholar]
  13. MANDELSTAM J. Turnover of protein in starved bacteria and its relationship to the induced synthesis of enzyme. Nature. 1957 Jun 8;179(4571):1179–1181. doi: 10.1038/1791179a0. [DOI] [PubMed] [Google Scholar]
  14. PAIGEN K. CHANGES IN THE INDUCIBILITY OF GALACTOKINASE AND BETA-GALACTOSIDASE DURING INHIBITION OF GROWTH IN ESCHERICHIA COLI. Biochim Biophys Acta. 1963 Oct 1;77:318–328. doi: 10.1016/0006-3002(63)90502-x. [DOI] [PubMed] [Google Scholar]
  15. POLLOCK M. R. THE DIFFERENTIAL EFFECT OF ACTINOMYCIN D ON THE BIOSYNTHESIS OF ENZYMES IN BACILLUS SUBTILIS AND BACILLUS CEREUS. Biochim Biophys Acta. 1963 Sep 17;76:80–93. [PubMed] [Google Scholar]
  16. PREISS J., DIECKMANN M., BERG P. The enzymic synthesis of amino acyl derivatives of ribonucleic acid. IV. The formation of the 3'-hydroxyl terminal trinucleotide sequence of amino acid-acceptor ribonucleic acid. J Biol Chem. 1961 Jun;236:1748–1757. [PubMed] [Google Scholar]
  17. REICH E., FRANKLIN R. M., SHATKIN A. J., TATUMEL Action of actinomycin D on animal cells and viruses. Proc Natl Acad Sci U S A. 1962 Jul 15;48:1238–1245. doi: 10.1073/pnas.48.7.1238. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. RORSCH A., EDELMAN A., COHEN J. A. The effect of ultraviolet irradiation of Escherichia coli strain B on the sucrose-gradient-sedimentation pattern of its cell-free extract. Biochim Biophys Acta. 1963 Feb 26;68:271–277. doi: 10.1016/0006-3002(63)90142-2. [DOI] [PubMed] [Google Scholar]
  19. SIBATANI A., MIZUNO N. SYNTHESIS OF RIBONUCLEIC ACIDS IN ESCHERICHIA COLI IRRADIATED WITH ULTRAVIOLET LIGHT. Biochim Biophys Acta. 1963 Oct 15;76:188–200. [PubMed] [Google Scholar]
  20. SIMON E. J. Inhibition of synthesis of RNA in E. coli by the narcotic drug laevorphanol. Nature. 1963 May 25;198:794–795. doi: 10.1038/198794a0. [DOI] [PubMed] [Google Scholar]
  21. SIMON E. J., VANPRAAG D. INHIBITION OF RNA SYNTHESIS IN ESCHERICHIA COLI BY LEVORPHANOL. Proc Natl Acad Sci U S A. 1964 May;51:877–883. doi: 10.1073/pnas.51.5.877. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. VOLKIN E., ASTRACHAN L. Phosphorus incorporation in Escherichia coli ribo-nucleic acid after infection with bacteriophage T2. Virology. 1956 Apr;2(2):149–161. doi: 10.1016/0042-6822(56)90016-2. [DOI] [PubMed] [Google Scholar]
  23. WAINFAN E., MANDEL L. R., BOREK E. Differential inhibitions of the synthesis of soluble and particulate RNA. Biochem Biophys Res Commun. 1963 Feb 18;10:315–320. doi: 10.1016/0006-291x(63)90531-x. [DOI] [PubMed] [Google Scholar]
  24. YANKOFSKY S. A., SPIEGELMAN S. The identification of the ribosomal RNA cistron by sequence complementarity. I. Specificity of complex formation. Proc Natl Acad Sci U S A. 1962 Jun 15;48:1069–1078. doi: 10.1073/pnas.48.6.1069. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Proceedings of the National Academy of Sciences of the United States of America are provided here courtesy of National Academy of Sciences

RESOURCES