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. 1964 Aug;52(2):478–485. doi: 10.1073/pnas.52.2.478

A SUGGESTED CONTROL GENE MECHANISM FOR THE EXCESSIVE PRODUCTION OF TYPES I AND III PORPHYRINS IN CONGENITAL ERYTHROPOIETIC PORPHYRIA*

C J Watson 1, W Runge 1, L Taddeini 1, Irene Bossenmater 1, Ruth Cardinal 1
PMCID: PMC300302  PMID: 14206613

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ALDRICH R. A., HAWKINSON V., GRINSTEIN M., WATSON C. J. Photosensitive or congenital porphyria with hemolytic anemia. I. Clinical and fundamental studies before and after splenectomy. Blood. 1951 Aug;6(8):685–698. [PubMed] [Google Scholar]
  2. AZIZ M. A., SCHWARTZ S., WATSON C. J. STUDIES OF COPROPORPHYRIN. VII. ADAPTATION OF THE ERIKSEN PAPER CHROMATOGRAPHIC METHOD TO THE QUANTITATIVE ANALYSIS OF THE ISOMERS IN NORMAL HUMAN URINE. J Lab Clin Med. 1964 Apr;63:585–595. [PubMed] [Google Scholar]
  3. BORSOOK H., LINGREL J. B., SCARO J. L., MILLETTE R. L. Synthesis of haemoglobin in relation to the maturation of erythroid cells. Nature. 1962 Oct 27;196:347–350. doi: 10.1038/196347a0. [DOI] [PubMed] [Google Scholar]
  4. BURNHAM B. F., PIERCE W. S., WILLIAMS K. R., BOYER M. H., KIRBY C. K. delta-aminolaevulate dehydratase from Rhodopseudomonas spheroides. Biochem J. 1963 Jun;87:462–472. doi: 10.1042/bj0870462. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. CANIVET J., RIMINGTON C. A chromatographic study of uroporphyrins from cases of cutaneous, acute and congenital porphyria. Biochem J. 1953 Dec;55(5):867–872. doi: 10.1042/bj0550867. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. CORNFORD P. A., BENSON A. A qualitative and quantitative study of the separation of uroporphyrin octamethyl esters I and III by dioxan chromatography. J Chromatogr. 1963 Feb;10:141–157. doi: 10.1016/s0021-9673(01)92287-3. [DOI] [PubMed] [Google Scholar]
  7. Cornford P. Transformation of porphobilinogen into porphyrins by preparations from human erythrocytes. Biochem J. 1964 Apr;91(1):64–73. doi: 10.1042/bj0910064. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. DRESEL E. I., FALK J. E. Studies on the biosynthesis of blood pigments. 2. Haem and porphyrin formation in intact chicken erythrocytes. Biochem J. 1956 May;63(1):72–79. doi: 10.1042/bj0630072. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. DRESEL E. I., FALK J. E. Studies on the biosynthesis of blood pigments. 3. Haem and porphyrin formation from delta-aminolaevulic acid and from porphobilinogen in haemolysed chicken erythrocytes. Biochem J. 1956 May;63(1):80–87. doi: 10.1042/bj0630080. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. GRAY C. H., MUIR I. M. H., NEUBERGER A. Studies in congenital porphyria; the incorporation of 15N into the haem and glycine of haemoglobin. Biochem J. 1950 Nov-Dec;47(5):542–548. doi: 10.1042/bj0470542. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. GRINSTEIN M., ALDRICH R. A., HAWKINSON V., LOWRY P., WATSON C. J. Photosensitive or congenital porphyria with hemolytic anemia. II. Isotopic studies of porphyrin and hemoglobin metabolism. Blood. 1951 Aug;6(8):699–705. [PubMed] [Google Scholar]
  12. HAEGER-ARONSEN B. ERYTHROPOIETIC PROTOPORPHYRIA. A NEW TYPE OF INBORN ERROR OF METABOLISM. Am J Med. 1963 Oct;35:450–454. doi: 10.1016/0002-9343(63)90144-x. [DOI] [PubMed] [Google Scholar]
  13. HEILMEYER L., CLOTTEN R., KERP L., MERKER H., PARRA C. A., WETZEL H. P. PORPHYRIA ERYTHROPOETICA CONGENITA GUENTHER. BERICHT UEBER ZWEI FAMILIEN MIT ERFASSUNG DER MERKMALSTRAEGER. Dtsch Med Wochenschr. 1963 Dec 20;88:2449–2456. doi: 10.1055/s-0028-1112376. [DOI] [PubMed] [Google Scholar]
  14. ISRAELS L. G., YAMAMOTO T., SKANDERBEG J., ZIPURSKY A. Shunt bilirubin: evidence for two components. Science. 1963 Mar 15;139(3559):1054–1055. doi: 10.1126/science.139.3559.1054. [DOI] [PubMed] [Google Scholar]
  15. JACOB F., MONOD J. Genetic regulatory mechanisms in the synthesis of proteins. J Mol Biol. 1961 Jun;3:318–356. doi: 10.1016/s0022-2836(61)80072-7. [DOI] [PubMed] [Google Scholar]
  16. LONDON I. M., WEST R., SHEMIN D., RITTENBERG D. Porphyrin formation and hemoglobin metabolism in congenital porphyria. J Biol Chem. 1950 May;184(1):365–371. [PubMed] [Google Scholar]
  17. MAGNUS I. A., JARRETT A., PRANKERD T. A., RIMINGTON C. Erythropoietic protoporphyria. A new porphyria syndrome with solar urticaria due to protoporphyrinaemia. Lancet. 1961 Aug 26;2(7200):448–451. doi: 10.1016/s0140-6736(61)92427-8. [DOI] [PubMed] [Google Scholar]
  18. MAURZERALL D. NORMAL PORPHYRIN METABOLISM. J Pediatr. 1964 Jan;64:5–16. doi: 10.1016/s0022-3476(64)80311-5. [DOI] [PubMed] [Google Scholar]
  19. MONOD J., CHANGEUX J. P., JACOB F. Allosteric proteins and cellular control systems. J Mol Biol. 1963 Apr;6:306–329. doi: 10.1016/s0022-2836(63)80091-1. [DOI] [PubMed] [Google Scholar]
  20. PARKER W. C., BEARN A. G. Application of genetic regulatory mechanisms to human genetics. Am J Med. 1963 May;34:680–691. doi: 10.1016/0002-9343(63)90107-4. [DOI] [PubMed] [Google Scholar]
  21. PEARSON C. M., RIMER D. G., MOMMAERTS W. F. A metabolic myopathy due to absence of muscle phosphorylase. Am J Med. 1961 Apr;30:502–517. doi: 10.1016/0002-9343(61)90075-4. [DOI] [PubMed] [Google Scholar]
  22. PORTER F. S., LOWE B. A. CONGENITAL ERYTHROPOIETIC PROTOPORPHYRIA. I. CASE REPORTS, CLINICAL STUDIES AND PORPHYRIN ANALYSES IN TWO BROTHERS. Blood. 1963 Nov;22:521–531. [PubMed] [Google Scholar]
  23. SCHMID R., SCHWARTZ S., SUNDBERG R. D. Erythropoietic (congenital) porphyria: A rare abnormality of the normoblasts. Blood. 1955 May;10(5):416–428. [PubMed] [Google Scholar]
  24. SCHMID R., SCHWARTZ S., WATSON C. J. Porphyrin content of bone marrow and liver in the various forms of porphyria. AMA Arch Intern Med. 1954 Feb;93(2):167–190. doi: 10.1001/archinte.1954.00240260001001. [DOI] [PubMed] [Google Scholar]
  25. SHEMIN D., RUSSELL C. S., ABRAMSKY T. The succinate-glycine cycle. I. The mechanism of pyrrole synthesis. J Biol Chem. 1955 Aug;215(2):613–626. [PubMed] [Google Scholar]
  26. STENT G. S. THE OPERON: ON ITS THIRD ANNIVERSARY. MODULATION OF TRANSFER RNA SPECIES CAN PROVIDE A WORKABLE MODEL OF AN OPERATOR-LESS OPERON. Science. 1964 May 15;144(3620):816–820. doi: 10.1126/science.144.3620.816. [DOI] [PubMed] [Google Scholar]
  27. TSCHUDY D. P., WELLAND F. H., COLLINS A., HUNTER G., Jr THE EFFECT OF CARBOHYDRATE FEEDING ON THE INDUCTION OF DELTA-AMINOLEVULINIC ACID SYNTHETASE. Metabolism. 1964 May;13:396–406. doi: 10.1016/0026-0495(64)90113-1. [DOI] [PubMed] [Google Scholar]
  28. WATSON C. J., LOWRY P. T., SCHMID R., HAWKINSON V. E., SCHWARTZ S. The manifestations of the different forms of porphyria in relation to chemical findings. Trans Assoc Am Physicians. 1951;64:345–352. [PubMed] [Google Scholar]
  29. WATSON C. J., PERMAN V., SPURRELL F. A., HOYT H. H., SCHWARTZ S. Some studies of the comparative biology of human and bovine erythropoietic porphyria. AMA Arch Intern Med. 1959 Mar;103(3):436–444. doi: 10.1001/archinte.1959.00270030092009. [DOI] [PubMed] [Google Scholar]
  30. WELLAND F. H., HELLMAN E. S., COLLINS A., HUNTER G. W., Jr, TSCHUDY D. P. FACTORS AFFECTING THE EXCRETION OF PORPHYRIN PRECURSORS BY PATIENTS WITH ACUTE INTERMITTENT PORPHYRIA. II. THE EFFECT OF ETHINYL ESTRADIOL. Metabolism. 1964 Mar;13:251–258. doi: 10.1016/0026-0495(64)90104-0. [DOI] [PubMed] [Google Scholar]
  31. WITTENBERG J., SHEMIN D. The location in protoporphyrin of the carbon atoms derived from the alpha-carbon atom of glycine. J Biol Chem. 1950 Jul;185(1):103–116. [PubMed] [Google Scholar]

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