Skip to main content
Proceedings of the National Academy of Sciences of the United States of America logoLink to Proceedings of the National Academy of Sciences of the United States of America
. 1964 Aug;52(2):613–634. doi: 10.1073/pnas.52.2.613

THE ORGANIZATION OF LIVING MATTER

George E Palade 1
PMCID: PMC300314  PMID: 14208366

Full text

PDF
613

Images in this article

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. APP A. A., JAGENDORF A. T. INCORPORATION OF LABELLED AMINO ACIDS BY CHLOROPLAST RIBOSOMES. Biochim Biophys Acta. 1963 Oct 15;76:286–292. [PubMed] [Google Scholar]
  2. BLAIR P. V., ODA T., GREEN D. E. STUDIES ON THE ELECTRON TRANSFER SYSTEM. LIV. ISOLATION OF THE UNIT OF ELECTRON TRANSFER. Biochemistry. 1963 Jul-Aug;2:756–764. doi: 10.1021/bi00904a023. [DOI] [PubMed] [Google Scholar]
  3. BRIERLEY G. P., BACHMANN E., GREEN D. E. Active transport of inorganic phosphate and magnesium ions by beef heart mitochondria. Proc Natl Acad Sci U S A. 1962 Nov 15;48:1928–1935. doi: 10.1073/pnas.48.11.1928. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. CARO L. G., PALADE G. E. PROTEIN SYNTHESIS, STORAGE, AND DISCHARGE IN THE PANCREATIC EXOCRINE CELL. AN AUTORADIOGRAPHIC STUDY. J Cell Biol. 1964 Mar;20:473–495. doi: 10.1083/jcb.20.3.473. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. CHANCE B., PARSONS D. F., WILLIAMS G. R. CYTOCHROME CONTENT OF MITOCHONDRIA STRIPPED OF INNER MEMBRANE STRUCTURE. Science. 1964 Jan 10;143(3602):136–139. doi: 10.1126/science.143.3602.136. [DOI] [PubMed] [Google Scholar]
  6. CHUN E. H., VAUGHAN M. H., Jr, RICH A. THE ISOLATION AND CHARACTERIZATION OF DNA ASSOCIATED WITH CHLOROPLAST PREPARATIONS. J Mol Biol. 1963 Aug;7:130–141. doi: 10.1016/s0022-2836(63)80042-x. [DOI] [PubMed] [Google Scholar]
  7. Chance B., Estabrook R. W., Lee C. P. Electron Transport in the Oxysome. Science. 1963 Apr 26;140(3565):379–380. doi: 10.1126/science.140.3565.379-c. [DOI] [PubMed] [Google Scholar]
  8. DALTON A. J., FELIX M. D. Cytologic and cytochemical characteristics of the Golgi substance of epithelial cells of the epididymis in situ, in homogenates and after isolation. Am J Anat. 1954 Mar;94(2):171–207. doi: 10.1002/aja.1000940202. [DOI] [PubMed] [Google Scholar]
  9. DE DUVE C., PRESSMAN B. C., GIANETTO R., WATTIAUX R., APPELMANS F. Tissue fractionation studies. 6. Intracellular distribution patterns of enzymes in rat-liver tissue. Biochem J. 1955 Aug;60(4):604–617. doi: 10.1042/bj0600604. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. DELUCA H. F., ENGSTROM G. W., RASMUSSEN H. The action of vitamin D and parathyroid hormone in vitro on calcium uptake and release by kidney mitochondria. Proc Natl Acad Sci U S A. 1962 Sep 15;48:1604–1609. doi: 10.1073/pnas.48.9.1604. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. EISENSTADT J., BRAWERMAN G. THE INCORPORATION OF AMINO ACIDS INTO THE PROTEIN OF CHLOROPLASTS AND CHLOROPLAST RIBOSOMES OF EUGLENA GRACILIS. Biochim Biophys Acta. 1963 Oct 15;76:319–321. [PubMed] [Google Scholar]
  12. ESSNER E., NOVIKOFF A. B., MASEK B. Adenosinetriphosphatase and 5-nucleotidase activities in the plasma membrane of liver cells as revealed by electron microscopy. J Biophys Biochem Cytol. 1958 Nov 25;4(6):711–716. doi: 10.1083/jcb.4.6.711. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. ESTABROOK R. W., HOLOWINSKY A. Studies on the content and organization of the respiratory enzymes of mitochondria. J Biophys Biochem Cytol. 1961 Jan;9:19–28. doi: 10.1083/jcb.9.1.19. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. FARQUHAR M. G., PALADE G. E. Junctional complexes in various epithelia. J Cell Biol. 1963 May;17:375–412. doi: 10.1083/jcb.17.2.375. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. FERNANDEZ-MORAN H. Cell-membrane ultrastructure. Low-temperature electron microsopy and x-ray diffraction studies of lipoprotein components in lamellar systems. Circulation. 1962 Nov;26:1039–1065. doi: 10.1161/01.cir.26.5.1039. [DOI] [PubMed] [Google Scholar]
  16. FITZ-JAMES P. C. Participation of the cytoplasmic membrane in the growth and spore fromation of bacilli. J Biophys Biochem Cytol. 1960 Oct;8:507–528. doi: 10.1083/jcb.8.2.507. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. FRENSTER J. H., ALLFREY V. G., MIRSKY A. E. REPRESSED AND ACTIVE CHROMATIN ISOLATED FROM INTERPHASE LYMPHOCYTES. Proc Natl Acad Sci U S A. 1963 Dec;50:1026–1032. doi: 10.1073/pnas.50.6.1026. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. GIBOR A., IZAWA M. THE DNA CONTENT OF THE CHLOROPLASTS OF ACETABULARIA. Proc Natl Acad Sci U S A. 1963 Dec;50:1164–1169. doi: 10.1073/pnas.50.6.1164. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. GLAUERT A. M., HOPWOOD D. A. The fine structure of Streptomyces coelicolor. I. The cytoplasmic membrane system. J Biophys Biochem Cytol. 1960 Jun;7:479–488. doi: 10.1083/jcb.7.3.479. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. HOAGLAND M. B. An enzymic mechanism for amino acid activation in animal tissues. Biochim Biophys Acta. 1955 Feb;16(2):288–289. doi: 10.1016/0006-3002(55)90218-3. [DOI] [PubMed] [Google Scholar]
  21. HOAGLAND M. B., KELLER E. B., ZAMECNIK P. C. Enzymatic carboxyl activation of amino acids. J Biol Chem. 1956 Jan;218(1):345–358. [PubMed] [Google Scholar]
  22. HOAGLAND M. B., STEPHENSON M. L., SCOTT J. F., HECHT L. I., ZAMECNIK P. C. A soluble ribonucleic acid intermediate in protein synthesis. J Biol Chem. 1958 Mar;231(1):241–257. [PubMed] [Google Scholar]
  23. HUANG R. C., BONNER J. Histone, a suppressor of chromosomal RNA synthesis. Proc Natl Acad Sci U S A. 1962 Jul 15;48:1216–1222. doi: 10.1073/pnas.48.7.1216. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. JACOB F., MONOD J. Genetic regulatory mechanisms in the synthesis of proteins. J Mol Biol. 1961 Jun;3:318–356. doi: 10.1016/s0022-2836(61)80072-7. [DOI] [PubMed] [Google Scholar]
  25. KEIR H. M., SMELLIE R. M., SIEBERT G. Intracellular location of DNA nucleotidyltransferase. Nature. 1962 Nov 24;196:752–754. doi: 10.1038/196752a0. [DOI] [PubMed] [Google Scholar]
  26. KROON A. M. Protein synthesis in heart mitochondria. I. Amino acid incorporation into the protein of isolated beefheart mitochondria and fractions derived from them by sonic oscillation. Biochim Biophys Acta. 1963 Jul 30;72:391–402. doi: 10.1016/0006-3002(63)90258-0. [DOI] [PubMed] [Google Scholar]
  27. LEHNINGER A. L. Oxidative phosphorylation. Harvey Lect. 1953;49:176–215. [PubMed] [Google Scholar]
  28. LEHNINGER A. L. Phosphorylation coupled to oxidation of dihydrodiphosphopyridine nucleotide. J Biol Chem. 1951 May;190(1):345–359. [PubMed] [Google Scholar]
  29. LEHNINGER A. L., ROSSI C. S., GREENAWALT J. W. Respiration-dependent accumulation of inorganic phosphate and Ca ions by rat liver mitochondria. Biochem Biophys Res Commun. 1963 Mar 25;10:444–448. doi: 10.1016/0006-291x(63)90377-2. [DOI] [PubMed] [Google Scholar]
  30. LUCK D. J. Formation of mitochondria in Neurospora crassa. A quantitative radioautographic study. J Cell Biol. 1963 Mar;16:483–499. doi: 10.1083/jcb.16.3.483. [DOI] [PMC free article] [PubMed] [Google Scholar]
  31. MAGGIO R., SIEKEVITZ P., PALADE G. E. STUDIES ON ISOLATED NUCLEI. II. ISOLATION AND CHEMICAL CHARACTERIZATION OF NUCLEOLAR AND NUCLEOPLASMIC SUBFRACTIONS. J Cell Biol. 1963 Aug;18:293–312. doi: 10.1083/jcb.18.2.293. [DOI] [PMC free article] [PubMed] [Google Scholar]
  32. NASS S., NASS M. M. INTRAMITOCHONDRIAL FIBERS WITH DNA CHARACTERISTICS. II. ENZYMATIC AND OTHER HYDROLYTIC TREATMENTS. J Cell Biol. 1963 Dec;19:613–629. doi: 10.1083/jcb.19.3.613. [DOI] [PMC free article] [PubMed] [Google Scholar]
  33. NEWBURGH R. W., CHELDELIN V. H. The intracellular distribution of pentose cycle activity in rabbit kidney and liver. J Biol Chem. 1956 Jan;218(1):89–96. [PubMed] [Google Scholar]
  34. PALADE G. E. A small particulate component of the cytoplasm. J Biophys Biochem Cytol. 1955 Jan;1(1):59–68. doi: 10.1083/jcb.1.1.59. [DOI] [PMC free article] [PubMed] [Google Scholar]
  35. PALADE G. E. An electron microscope study of the mitochondrial structure. J Histochem Cytochem. 1953 Jul;1(4):188–211. doi: 10.1177/1.4.188. [DOI] [PubMed] [Google Scholar]
  36. PALAY S. L., PALADE G. E. The fine structure of neurons. J Biophys Biochem Cytol. 1955 Jan;1(1):69–88. doi: 10.1083/jcb.1.1.69. [DOI] [PMC free article] [PubMed] [Google Scholar]
  37. PARK R. B., PON N. G. Correlation of structure with function in Spinacea oleracea chloroplasts. J Mol Biol. 1961 Feb;3:1–10. doi: 10.1016/s0022-2836(61)80002-8. [DOI] [PubMed] [Google Scholar]
  38. PEACHEY L. D. ELECTRON MICROSCOPIC OBSERVATIONS ON THE ACCUMULATION OF DIVALENT CATIONS IN INTRAMITOCHONDRIAL GRANULES. J Cell Biol. 1964 Jan;20:95–111. doi: 10.1083/jcb.20.1.95. [DOI] [PMC free article] [PubMed] [Google Scholar]
  39. PORTER K. R., BRUNI C. An electron microscope study of the early effects of 3'-Me-DAB on rat liver cells. Cancer Res. 1959 Nov;19:997–1009. [PubMed] [Google Scholar]
  40. Parsons D. F. Mitochondrial Structure: Two Types of Subunits on Negatively Stained Mitochondrial Membranes. Science. 1963 May 31;140(3570):985–987. doi: 10.1126/science.140.3570.985. [DOI] [PubMed] [Google Scholar]
  41. REVEL J. P., NAPOLITANO L., FAWCETT D. W. Identification of glycogen in electron micrographs of thin tissue sections. J Biophys Biochem Cytol. 1960 Dec;8:575–589. doi: 10.1083/jcb.8.3.575. [DOI] [PMC free article] [PubMed] [Google Scholar]
  42. RIS H., PLAUT W. Ultrastructure of DNA-containing areas in the chloroplast of Chlamydomonas. J Cell Biol. 1962 Jun;13:383–391. doi: 10.1083/jcb.13.3.383. [DOI] [PMC free article] [PubMed] [Google Scholar]
  43. ROBERTSON J. D. The molecular structure and contact relationships of cell membranes. Prog Biophys Mol Biol. 1960;10:343–418. [PubMed] [Google Scholar]
  44. ROBERTSON J. D. The ultrastructure of cell membranes and their derivatives. Biochem Soc Symp. 1959;16:3–43. [PubMed] [Google Scholar]
  45. ROODYN D. B. A survey of metabolic studies on isolated mammalian nuclei. Int Rev Cytol. 1959;8:279–344. doi: 10.1016/s0074-7696(08)62734-5. [DOI] [PubMed] [Google Scholar]
  46. ROODYN D. B., REIS P. J., WORK T. S. Protein synthesis in mitochondria. Requirements for the incorporation of radioactive amino acids into mitochondrial protein. Biochem J. 1961 Jul;80:9–21. doi: 10.1042/bj0800009. [DOI] [PMC free article] [PubMed] [Google Scholar]
  47. RYTER A., KELLENBERGER E., BIRCHANDERSEN A., MAALOE O. Etude au microscope électronique de plasmas contenant de l'acide désoxyribonucliéique. I. Les nucléoides des bactéries en croissance active. Z Naturforsch B. 1958 Sep;13B(9):597–605. [PubMed] [Google Scholar]
  48. SAGER R., PALADE G. E. Structure and development of the chloroplast in Chlamydomonas. I. The normal green cell. J Biophys Biochem Cytol. 1957 May 25;3(3):463–488. doi: 10.1083/jcb.3.3.463. [DOI] [PMC free article] [PubMed] [Google Scholar]
  49. STEPHENSON M. L., THIMANN K. V., ZAMECNIK P. C. Incorporation of C14-amino acids into proteins of leaf disks and cell-free fractions of tobacco leaves. Arch Biochem Biophys. 1956 Nov;65(1):194–209. doi: 10.1016/0003-9861(56)90187-4. [DOI] [PubMed] [Google Scholar]
  50. STOECKENIUS W. Some observations on negatively stained mitochondria. J Cell Biol. 1963 May;17:443–454. doi: 10.1083/jcb.17.2.443. [DOI] [PMC free article] [PubMed] [Google Scholar]
  51. Sister M J SMITH, KEIR H. M. DNA nucleotidyltransferase in nuclei and cytoplasm prepared from thymus tissue in nonaqueous media. Biochim Biophys Acta. 1963 Apr 30;68:578–588. doi: 10.1016/0006-3002(63)90187-2. [DOI] [PubMed] [Google Scholar]
  52. TEDESCHI H., HARRIS D. L. Some observations on the photometric estimation of mitochondrial volume. Biochim Biophys Acta. 1958 May;28(2):392–402. doi: 10.1016/0006-3002(58)90487-6. [DOI] [PubMed] [Google Scholar]
  53. TEDESCHI H., JAMES J. M., ANTHONY W. PHOTOMETRIC EVIDENCE FOR THE OSMOTIC BEHAVIOR OF RAT LIVER MICROSOMES. J Cell Biol. 1963 Sep;18:503–513. doi: 10.1083/jcb.18.3.503. [DOI] [PMC free article] [PubMed] [Google Scholar]
  54. VAN ITERSON, LEENE W. A CYTOCHEMICAL LOCALIZATION OF REDUCTIVE SITES IN A GRAM-POSITIVE BACTERIUM. TELLURITE REDUCTION IN BACILLUS SUBTILIS. J Cell Biol. 1964 Mar;20:361–375. doi: 10.1083/jcb.20.3.361. [DOI] [PMC free article] [PubMed] [Google Scholar]
  55. VASINGTON F. D., MURPHY J. V. Ca ion uptake by rat kidney mitochondria and its dependence on respiration and phosphorylation. J Biol Chem. 1962 Aug;237:2670–2677. [PubMed] [Google Scholar]
  56. WATSON M. L. The nuclear envelope; its structure and relation to cytoplasmic membranes. J Biophys Biochem Cytol. 1955 May 25;1(3):257–270. doi: 10.1083/jcb.1.3.257. [DOI] [PMC free article] [PubMed] [Google Scholar]
  57. WEIBULL C. Characterization of the protoplasmic constituents of bacillus megaterium. J Bacteriol. 1953 Dec;66(6):696–702. doi: 10.1128/jb.66.6.696-702.1953. [DOI] [PMC free article] [PubMed] [Google Scholar]
  58. WETTSTEIN F. O., STAEHELIN T., NOLL H. Ribosomal aggregate engaged in protein synthesis: characterization of the ergosome. Nature. 1963 Feb 2;197:430–435. doi: 10.1038/197430a0. [DOI] [PubMed] [Google Scholar]
  59. Warner J. R., Rich A., Hall C. E. Electron Microscope Studies of Ribosomal Clusters Synthesizing Hemoglobin. Science. 1962 Dec 28;138(3548):1399–1403. doi: 10.1126/science.138.3548.1399. [DOI] [PubMed] [Google Scholar]
  60. YANKOFSKY S. A., SPIEGELMAN S. Distinct cistrons for the two ribosomal RNA components. Proc Natl Acad Sci U S A. 1963 Apr;49:538–544. doi: 10.1073/pnas.49.4.538. [DOI] [PMC free article] [PubMed] [Google Scholar]
  61. van ITERSON, RUYS A. C. The fine structure of the Mycoplasmataceae (microorganisms of the pleuropneumonia group PPLO). 1. Mycoplasma hominis, M. fermentans and M. salivarium. J Ultrastruct Res. 1960 Feb;3:282–301. doi: 10.1016/s0022-5320(60)80015-9. [DOI] [PubMed] [Google Scholar]

Articles from Proceedings of the National Academy of Sciences of the United States of America are provided here courtesy of National Academy of Sciences

RESOURCES