N-(4-Methyl­benzo­yl)benzene­sulfonamide

Abstract

In the title compound, C₁₄H₁₃NO₃S, the conformation of the N—H bond in the C—SO₂—NH—C(O) segment is anti to the C=O bond. The dihedral angle between the sulfonyl benzene ring and the S—N—C—O segment (r.m.s. deviation = 0.039 Å) is 77.1 (1)° and that between the sulfonyl and benzoyl benzene rings is 71.9 (1)°.

Related literature

For background to our study of the effect of ring and side-chain substituents on the crystal structures of N-aromatic sulfonamides and for related structures, see: Gowda et al. (2009 ▶); Suchetan et al. (2009 ▶, 2010 ▶).

Experimental

Crystal data

• C₁₄H₁₃NO₃S

• M _r = 275.31

• Triclinic,

• a = 5.5519 (6) Å

• b = 10.541 (1) Å

• c = 11.105 (1) Å

• α = 85.654 (9)°

• β = 83.667 (9)°

• γ = 81.949 (9)°

• V = 638.36 (11) ų

• Z = 2

• Mo Kα radiation

• μ = 0.26 mm⁻¹

• T = 299 K

• 0.40 × 0.32 × 0.16 mm

Data collection

• Oxford Diffraction Xcalibur diffractometer with a Sapphire CCD detector

• Absorption correction: multi-scan (CrysAlis RED; Oxford Diffraction, 2009 ▶) T _min = 0.904, T _max = 0.960

• 4293 measured reflections

• 2595 independent reflections

• 2207 reflections with I > 2σ(I)

• R _int = 0.017

Refinement

• R[F ² > 2σ(F ²)] = 0.038

• wR(F ²) = 0.109

• S = 1.08

• 2595 reflections

• 173 parameters

• H-atom parameters constrained

• Δρ_max = 0.24 e Å⁻³

• Δρ_min = −0.30 e Å⁻³

Data collection: CrysAlis CCD (Oxford Diffraction, 2009 ▶); cell refinement: CrysAlis RED (Oxford Diffraction, 2009 ▶); data reduction: CrysAlis RED; program(s) used to solve structure: SHELXS97 (Sheldrick, 2008 ▶); program(s) used to refine structure: SHELXL97 (Sheldrick, 2008 ▶); molecular graphics: PLATON (Spek, 2009 ▶); software used to prepare material for publication: SHELXL97.

Supplementary Material

Additional supplementary materials: crystallographic information; 3D view; checkCIF report

supplementary crystallographic information

Comment

As a part of studying the effect of ring and the side chain substituents on the crystal structures of N-aromatic sulfonamides (Gowda et al., 2009; Suchetan et al., 2009, 2010), the crystal structure of N-(4-methylbenzoyl)benzenesulfonamide has been determined (Fig. 1). The conformation of the N—H bond in the C—SO₂—NH—C(O) segment is anti to the C═O bond, similar to those observed in N-(benzoyl)benzenesulfonamide (II) (Gowda et al., 2009), N-(benzoyl)-4-methylbenzenesulfonamide (III) (Suchetan et al., 2010) and N-(4-chlorobenzoyl)-benzenesulfonamide (IV) (Suchetan et al., 2009).

The molecules are twisted at the S—N bonds with the C—SO₂—NH—C torsional angle of 67.4 (1)°, compared to the values of -66.9 (3)° in (II), 73.2 (2)° in (III) and 69.4 (2)° in (IV).

The dihedral angle between the sulfonyl-bound benzene ring and the S—N—C—O segment (r.m.s. deviation 0.039 Å) is 77.1 (1)°, compared to the values of 86.5 (1)° in (II), 76.5 (1)° in (III) and 75.7 (1)° in (IV).

The dihedral angle between the sulfonyl and the benzoyl benzene rings is 71.9 (1)°, compared to the values of 80.3 (1) in (II), 79.4 (1)° in (III), and 68.6 (1)° in (IV).

Experimental

The title compound was prepared by refluxing a mixture of 4-methylbenzoic acid, benzenesulfonamide and phosphorous oxy chloride for 3 h on a water bath. The resultant mixture was cooled and poured into ice cold water. The solid obtained was filtered, washed thoroughly with water and then dissolved in a sodium bicarbonate solution. The compound was later reprecipitated by acidifying the filtered solution with dilute HCl. It was filtered, dried and recrystallized. Colourless needle-shaped single crystals of the title compound used in X-ray diffraction studies were obtained by slow evaporation of its toluene solution at room temperature.

Refinement

H atoms were positioned with idealized geometry using a riding model with N–H = 0.86 Å, C–H = 0.93–0.96 Å and were refined with isotropic displacement parameters (set to 1.2 times of the U_eq of the parent atom).

Figures

Fig. 1.

Molecular structure of the title compound, showing the atom-labelling scheme. Displacement ellipsoids are drawn at the 50% probability level.

Crystal data

C14H13NO3S	Z = 2
Mr = 275.31	F(000) = 288
Triclinic, P1	Dx = 1.432 Mg m−3
Hall symbol: -P 1	Mo Kα radiation, λ = 0.71073 Å
a = 5.5519 (6) Å	Cell parameters from 2679 reflections
b = 10.541 (1) Å	θ = 2.6–27.7°
c = 11.105 (1) Å	µ = 0.26 mm−1
α = 85.654 (9)°	T = 299 K
β = 83.667 (9)°	Needle, colourless
γ = 81.949 (9)°	0.40 × 0.32 × 0.16 mm
V = 638.36 (11) Å3

Data collection

Oxford Diffraction Xcalibur diffractometer with a Sapphire CCD detector	2595 independent reflections
Radiation source: fine-focus sealed tube	2207 reflections with I > 2σ(I)
graphite	Rint = 0.017
Rotation method data acquisition using ω and φ scans	θmax = 26.4°, θmin = 2.6°
Absorption correction: multi-scan (CrysAlis RED; Oxford Diffraction, 2009)	h = −6→6
Tmin = 0.904, Tmax = 0.960	k = −13→11
4293 measured reflections	l = −13→12

Refinement

Refinement on F2	Primary atom site location: structure-invariant direct methods
Least-squares matrix: full	Secondary atom site location: difference Fourier map
R[F2 > 2σ(F2)] = 0.038	Hydrogen site location: inferred from neighbouring sites
wR(F2) = 0.109	H-atom parameters constrained
S = 1.08	w = 1/[σ2(Fo2) + (0.0564P)2 + 0.1768P] where P = (Fo2 + 2Fc2)/3
2595 reflections	(Δ/σ)max = 0.020
173 parameters	Δρmax = 0.24 e Å−3
0 restraints	Δρmin = −0.30 e Å−3

Special details

Geometry. All e.s.d.'s (except the e.s.d. in the dihedral angle between two l.s. planes) are estimated using the full covariance matrix. The cell e.s.d.'s are taken into account individually in the estimation of e.s.d.'s in distances, angles and torsion angles; correlations between e.s.d.'s in cell parameters are only used when they are defined by crystal symmetry. An approximate (isotropic) treatment of cell e.s.d.'s is used for estimating e.s.d.'s involving l.s. planes.

Refinement. Refinement of F2 against ALL reflections. The weighted R-factor wR and goodness of fit S are based on F2, conventional R-factors R are based on F, with F set to zero for negative F2. The threshold expression of F2 > σ(F2) is used only for calculating R-factors(gt) etc. and is not relevant to the choice of reflections for refinement. R-factors based on F2 are statistically about twice as large as those based on F, and R- factors based on ALL data will be even larger.

Fractional atomic coordinates and isotropic or equivalent isotropic displacement parameters (Ų)

	x	y	z	Uiso*/Ueq
C1	0.0535 (3)	0.17087 (15)	0.37945 (14)	0.0370 (3)
C2	0.2512 (3)	0.07861 (18)	0.39763 (17)	0.0491 (4)
H2	0.3709	0.0944	0.4448	0.059*
C3	0.2687 (4)	−0.03734 (19)	0.34486 (19)	0.0557 (5)
H3	0.4008	−0.1001	0.3567	0.067*
C4	0.0919 (4)	−0.06031 (17)	0.27507 (18)	0.0514 (5)
H4	0.1050	−0.1383	0.2394	0.062*
C5	−0.1047 (4)	0.03194 (19)	0.25778 (17)	0.0517 (5)
H5	−0.2241	0.0157	0.2106	0.062*
C6	−0.1262 (3)	0.14869 (17)	0.31001 (16)	0.0439 (4)
H6	−0.2592	0.2110	0.2985	0.053*
C7	0.1508 (3)	0.45512 (14)	0.24545 (14)	0.0362 (3)
C8	0.2982 (3)	0.55415 (14)	0.18611 (13)	0.0345 (3)
C9	0.4790 (3)	0.60283 (16)	0.23892 (15)	0.0393 (4)
H9	0.5113	0.5748	0.3177	0.047*
C10	0.6111 (3)	0.69266 (17)	0.17506 (15)	0.0429 (4)
H10	0.7328	0.7235	0.2113	0.051*
C11	0.5653 (3)	0.73765 (16)	0.05771 (15)	0.0403 (4)
C12	0.3825 (3)	0.69012 (18)	0.00681 (16)	0.0471 (4)
H12	0.3477	0.7197	−0.0712	0.056*
C13	0.2508 (3)	0.60001 (17)	0.06897 (15)	0.0451 (4)
H13	0.1291	0.5695	0.0324	0.054*
C14	0.7134 (4)	0.83301 (19)	−0.01353 (19)	0.0553 (5)
H14A	0.8409	0.7882	−0.0661	0.066*
H14B	0.7844	0.8795	0.0415	0.066*
H14C	0.6090	0.8920	−0.0613	0.066*
N1	0.2026 (3)	0.40757 (13)	0.36175 (13)	0.0466 (4)
H1N	0.3319	0.4262	0.3887	0.056*
O1	0.1439 (3)	0.29602 (14)	0.55935 (12)	0.0705 (5)
O2	−0.2229 (3)	0.37520 (13)	0.45410 (13)	0.0618 (4)
O3	−0.0051 (2)	0.41356 (12)	0.19791 (11)	0.0493 (3)
S1	0.02709 (9)	0.31703 (4)	0.45017 (4)	0.04709 (17)

Atomic displacement parameters (Ų)

	U11	U22	U33	U12	U13	U23
C1	0.0466 (9)	0.0344 (8)	0.0314 (8)	−0.0135 (7)	−0.0018 (6)	0.0008 (6)
C2	0.0481 (10)	0.0518 (10)	0.0501 (10)	−0.0113 (8)	−0.0125 (8)	−0.0001 (8)
C3	0.0556 (11)	0.0452 (10)	0.0633 (12)	−0.0003 (8)	−0.0039 (9)	0.0008 (9)
C4	0.0641 (12)	0.0386 (9)	0.0524 (11)	−0.0164 (8)	0.0059 (9)	−0.0079 (8)
C5	0.0555 (11)	0.0545 (11)	0.0510 (11)	−0.0219 (9)	−0.0081 (8)	−0.0105 (8)
C6	0.0453 (9)	0.0427 (9)	0.0453 (9)	−0.0096 (7)	−0.0076 (7)	−0.0014 (7)
C7	0.0448 (9)	0.0310 (8)	0.0330 (8)	−0.0035 (6)	−0.0065 (6)	−0.0027 (6)
C8	0.0391 (8)	0.0319 (8)	0.0313 (8)	−0.0004 (6)	−0.0035 (6)	−0.0018 (6)
C9	0.0429 (9)	0.0439 (9)	0.0313 (8)	−0.0054 (7)	−0.0071 (6)	0.0016 (6)
C10	0.0417 (9)	0.0476 (9)	0.0408 (9)	−0.0092 (7)	−0.0061 (7)	−0.0030 (7)
C11	0.0419 (9)	0.0359 (8)	0.0397 (8)	0.0000 (7)	0.0026 (7)	−0.0005 (6)
C12	0.0571 (11)	0.0495 (10)	0.0342 (8)	−0.0070 (8)	−0.0097 (7)	0.0074 (7)
C13	0.0524 (10)	0.0494 (10)	0.0366 (9)	−0.0127 (8)	−0.0145 (7)	0.0030 (7)
C14	0.0585 (12)	0.0500 (11)	0.0552 (11)	−0.0114 (9)	0.0036 (9)	0.0053 (9)
N1	0.0680 (10)	0.0420 (8)	0.0359 (7)	−0.0246 (7)	−0.0154 (7)	0.0053 (6)
O1	0.1269 (14)	0.0621 (9)	0.0333 (7)	−0.0439 (9)	−0.0218 (7)	0.0059 (6)
O2	0.0745 (10)	0.0493 (8)	0.0565 (8)	−0.0036 (7)	0.0148 (7)	−0.0111 (6)
O3	0.0544 (7)	0.0519 (7)	0.0459 (7)	−0.0172 (6)	−0.0166 (6)	0.0056 (5)
S1	0.0756 (3)	0.0393 (2)	0.0295 (2)	−0.0204 (2)	−0.00330 (19)	−0.00178 (16)

Geometric parameters (Å, °)

C1—C6	1.381 (2)	C9—C10	1.384 (2)
C1—C2	1.382 (3)	C9—H9	0.93
C1—S1	1.7626 (16)	C10—C11	1.391 (2)
C2—C3	1.382 (3)	C10—H10	0.93
C2—H2	0.93	C11—C12	1.383 (2)
C3—C4	1.373 (3)	C11—C14	1.510 (2)
C3—H3	0.93	C12—C13	1.377 (2)
C4—C5	1.376 (3)	C12—H12	0.93
C4—H4	0.93	C13—H13	0.93
C5—C6	1.385 (3)	C14—H14A	0.96
C5—H5	0.93	C14—H14B	0.96
C6—H6	0.93	C14—H14C	0.96
C7—O3	1.209 (2)	N1—S1	1.6529 (15)
C7—N1	1.395 (2)	N1—H1N	0.86
C7—C8	1.487 (2)	O1—S1	1.4257 (14)
C8—C9	1.391 (2)	O2—S1	1.4340 (15)
C8—C13	1.393 (2)
C6—C1—C2	121.09 (16)	C9—C10—C11	121.20 (16)
C6—C1—S1	119.75 (13)	C9—C10—H10	119.4
C2—C1—S1	119.13 (13)	C11—C10—H10	119.4
C3—C2—C1	119.19 (17)	C12—C11—C10	117.86 (15)
C3—C2—H2	120.4	C12—C11—C14	120.74 (16)
C1—C2—H2	120.4	C10—C11—C14	121.39 (16)
C4—C3—C2	120.29 (18)	C13—C12—C11	121.56 (16)
C4—C3—H3	119.9	C13—C12—H12	119.2
C2—C3—H3	119.9	C11—C12—H12	119.2
C3—C4—C5	120.12 (17)	C12—C13—C8	120.55 (16)
C3—C4—H4	119.9	C12—C13—H13	119.7
C5—C4—H4	119.9	C8—C13—H13	119.7
C4—C5—C6	120.56 (17)	C11—C14—H14A	109.5
C4—C5—H5	119.7	C11—C14—H14B	109.5
C6—C5—H5	119.7	H14A—C14—H14B	109.5
C1—C6—C5	118.75 (17)	C11—C14—H14C	109.5
C1—C6—H6	120.6	H14A—C14—H14C	109.5
C5—C6—H6	120.6	H14B—C14—H14C	109.5
O3—C7—N1	119.51 (15)	C7—N1—S1	123.07 (12)
O3—C7—C8	123.77 (14)	C7—N1—H1N	118.5
N1—C7—C8	116.70 (14)	S1—N1—H1N	118.5
C9—C8—C13	118.37 (15)	O1—S1—O2	119.65 (10)
C9—C8—C7	124.69 (14)	O1—S1—N1	103.47 (8)
C13—C8—C7	116.93 (14)	O2—S1—N1	109.71 (8)
C10—C9—C8	120.45 (15)	O1—S1—C1	109.18 (9)
C10—C9—H9	119.8	O2—S1—C1	108.24 (8)
C8—C9—H9	119.8	N1—S1—C1	105.73 (8)
C6—C1—C2—C3	0.2 (3)	C10—C11—C12—C13	−0.7 (3)
S1—C1—C2—C3	178.30 (14)	C14—C11—C12—C13	177.89 (17)
C1—C2—C3—C4	0.1 (3)	C11—C12—C13—C8	0.2 (3)
C2—C3—C4—C5	−0.3 (3)	C9—C8—C13—C12	0.8 (3)
C3—C4—C5—C6	0.2 (3)	C7—C8—C13—C12	−178.80 (16)
C2—C1—C6—C5	−0.4 (3)	O3—C7—N1—S1	−12.2 (2)
S1—C1—C6—C5	−178.42 (13)	C8—C7—N1—S1	168.97 (11)
C4—C5—C6—C1	0.2 (3)	C7—N1—S1—O1	−177.83 (14)
O3—C7—C8—C9	−179.72 (16)	C7—N1—S1—O2	−49.07 (16)
N1—C7—C8—C9	−0.9 (2)	C7—N1—S1—C1	67.44 (15)
O3—C7—C8—C13	−0.1 (2)	C6—C1—S1—O1	149.92 (14)
N1—C7—C8—C13	178.70 (15)	C2—C1—S1—O1	−28.17 (17)
C13—C8—C9—C10	−1.3 (2)	C6—C1—S1—O2	18.16 (16)
C7—C8—C9—C10	178.29 (15)	C2—C1—S1—O2	−159.93 (14)
C8—C9—C10—C11	0.8 (3)	C6—C1—S1—N1	−99.34 (14)
C9—C10—C11—C12	0.2 (3)	C2—C1—S1—N1	82.58 (15)
C9—C10—C11—C14	−178.37 (16)