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. Author manuscript; available in PMC: 2011 Sep 24.
Published in final edited form as: Vaccine. 2010 Aug 4;28(41):6740–6748. doi: 10.1016/j.vaccine.2010.07.075

Figure 5.

Figure 5

Antibody responses in mice immunized with LF domains in combination with PA. (A) LF-specific IgG antibody and (B) toxin neutralizing activity (TNA) titers in mice immunized with LF domains alone or in combination with PA. BALB/c mice (10 per group) received 10 µg of domain protein or 10 µg of domain protein + 10 µg of PA together with alum on days 0 and 28. Results are expressed as LF geometric mean IgG titer with 95% confidence intervals. TNA titers represent mean with range. Vertical lines indicate immunization days. LF IgG titers were compared at day 56 (peak); * denotes higher responses to LF+PA and LFD2–4+PA vs. all other groups and lowest responses to LFD3+ PA vs. all other groups (p<0.05). For TNA titers, * denotes higher titers to LFD1+PA vs. all other domains (p<0.05).