N-[(Piperidin-1-yl)carbothioyl]benz­amide

Abstract

In the title compound, C₁₃H₁₆N₂OS, the piperidine ring exhibit a classical chair conformation. In the crystal, the mol­ecules are linked by N—H⋯O hydrogen bonds, forming zigzag chains running parallel to the c axis.

Related literature

For complexes with the title compound as a ligand, see: Mohamadou et al. (1994 ▶); Salyn et al. (1977 ▶); Röbisch et al. (1982 ▶).

Experimental

Crystal data

• C₁₃H₁₆N₂OS

• M _r = 248.34

• Monoclinic,

• a = 10.913 (3) Å

• b = 14.297 (4) Å

• c = 8.323 (2) Å

• β = 102.212 (6)°

• V = 1269.2 (6) ų

• Z = 4

• Mo Kα radiation

• μ = 0.24 mm⁻¹

• T = 298 K

• 0.50 × 0.41 × 0.38 mm

Data collection

• Bruker SMART APEX CCD area-detector diffractometer

• Absorption correction: multi-scan (SADABS; Bruker, 2000 ▶) T _min = 0.889, T _max = 0.915

• 7091 measured reflections

• 2221 independent reflections

• 1727 reflections with I > 2σ(I)

• R _int = 0.031

Refinement

• R[F ² > 2σ(F ²)] = 0.047

• wR(F ²) = 0.126

• S = 1.08

• 2221 reflections

• 154 parameters

• H-atom parameters constrained

• Δρ_max = 0.29 e Å⁻³

• Δρ_min = −0.27 e Å⁻³

Data collection: SMART (Bruker, 2000 ▶); cell refinement: SAINT (Bruker, 2000 ▶); data reduction: SAINT; program(s) used to solve structure: SHELXS97 (Sheldrick, 2008 ▶); program(s) used to refine structure: SHELXL97 (Sheldrick, 2008 ▶); molecular graphics: XP (Sheldrick, 2008 ▶); software used to prepare material for publication: SHELXTL (Sheldrick, 2008 ▶), PARST (Nardelli, 1995 ▶) and PLATON (Spek, 2009 ▶).

Supplementary Material

Additional supplementary materials: crystallographic information; 3D view; checkCIF report

Table 1. Hydrogen-bond geometry (Å, °).

D—H⋯A	D—H	H⋯A	D⋯A	D—H⋯A
N1—H1A⋯O1i	0.86	2.18	2.949 (2)	149

Symmetry code: (i) .

supplementary crystallographic information

Comment

N,N-dialkyl-N'-benzoyl thioureas are known to form stable complexes with lage number of transition metals. The title compound has been used extensivelly as ligand to form stable complexes with Cu, Ni, Co, Pt, Pd, Hg, Ru, Os, Rh and Ir (Mohamadou et al., 1994; Salyn et al., 1977; Röbisch et al., 1982). The six-membered piperidine ring has a classical chair conformation.

In the crystal, the molecules are linked by N—H···O hydrogen bonds forming zigzag chains running parallel to the crystallographic c-axis.

Experimental

A solution of benzoyl chloride (10 mmol) in acetone was added slowly to a equimolar solution of ammonium thiocyanate in acetone. The reaction mixture was stirred at room temperature before adding piperidine (10 mmol) slowly and left stirring at room temperature for 4 h. The mixture was poured on to a water-ice mixture and then filtered. The pure product was recrystallized to give colourless crystals (70% yield).

Refinement

H atom positions were calculated and they were refined using a riding model with U_iso=1.2U_eq(C,N) and with C_aromatic-H = 0.93 Å or C-H = 0.97 Å, and N-H = 0.86 Å.

Figures

Fig. 1.

The molecular structure of N-(piperidine-1-carbamothioyl)benzamide, with displacement ellipsoids are drawn at the 50% probability level.

Fig. 2.

Crystal packing of the title compound viewed down the c-axis. Hydrogen bonds are drawn as dashed lines.

Crystal data

C13H16N2OS	F(000) = 528
Mr = 248.34	Dx = 1.300 Mg m−3
Monoclinic, P21/c	Mo Kα radiation, λ = 0.71073 Å
Hall symbol: -P 2ybc	Cell parameters from 1679 reflections
a = 10.913 (3) Å	θ = 1.9–25.0°
b = 14.297 (4) Å	µ = 0.24 mm−1
c = 8.323 (2) Å	T = 298 K
β = 102.212 (6)°	Needle, colourless
V = 1269.2 (6) Å3	0.50 × 0.41 × 0.38 mm
Z = 4

Data collection

Bruker SMART APEX CCD area-detector diffractometer	2221 independent reflections
Radiation source: fine-focus sealed tube	1727 reflections with I > 2σ(I)
graphite	Rint = 0.031
ω scan	θmax = 25.0°, θmin = 1.9°
Absorption correction: multi-scan (SADABS; Bruker, 2000)	h = −12→8
Tmin = 0.889, Tmax = 0.915	k = −16→17
7091 measured reflections	l = −9→9

Refinement

Refinement on F2	Primary atom site location: structure-invariant direct methods
Least-squares matrix: full	Secondary atom site location: difference Fourier map
R[F2 > 2σ(F2)] = 0.047	Hydrogen site location: inferred from neighbouring sites
wR(F2) = 0.126	H-atom parameters constrained
S = 1.08	w = 1/[σ2(Fo2) + (0.0702P)2 + 0.1087P] where P = (Fo2 + 2Fc2)/3
2221 reflections	(Δ/σ)max < 0.001
154 parameters	Δρmax = 0.29 e Å−3
0 restraints	Δρmin = −0.27 e Å−3

Special details

Geometry. All e.s.d.'s (except the e.s.d. in the dihedral angle between two l.s. planes) are estimated using the full covariance matrix. The cell e.s.d.'s are taken into account individually in the estimation of e.s.d.'s in distances, angles and torsion angles; correlations between e.s.d.'s in cell parameters are only used when they are defined by crystal symmetry. An approximate (isotropic) treatment of cell e.s.d.'s is used for estimating e.s.d.'s involving l.s. planes.

Refinement. Refinement of F2 against ALL reflections. The weighted R-factor wR and goodness of fit S are based on F2, conventional R-factors R are based on F, with F set to zero for negative F2. The threshold expression of F2 > σ(F2) is used only for calculating R-factors(gt) etc. and is not relevant to the choice of reflections for refinement. R-factors based on F2 are statistically about twice as large as those based on F, and R- factors based on ALL data will be even larger.

Fractional atomic coordinates and isotropic or equivalent isotropic displacement parameters (Ų)

	x	y	z	Uiso*/Ueq
S1	0.93006 (6)	0.86988 (4)	0.12334 (8)	0.0562 (2)
O1	1.15395 (14)	0.65828 (11)	0.05387 (17)	0.0500 (4)
N1	1.07366 (15)	0.72851 (13)	0.2538 (2)	0.0419 (4)
H1A	1.0864	0.7427	0.3564	0.050*
N2	0.88426 (17)	0.68658 (13)	0.0845 (2)	0.0444 (5)
C1	1.2732 (2)	0.63954 (15)	0.4875 (3)	0.0472 (6)
H1B	1.1968	0.6424	0.5201	0.057*
C2	1.3821 (3)	0.61791 (16)	0.6010 (3)	0.0546 (6)
H2A	1.3790	0.6072	0.7102	0.066*
C3	1.4937 (2)	0.61231 (16)	0.5526 (3)	0.0560 (7)
H3A	1.5665	0.5981	0.6294	0.067*
C4	1.4996 (2)	0.62748 (16)	0.3912 (3)	0.0526 (6)
H4A	1.5760	0.6230	0.3590	0.063*
C5	1.3923 (2)	0.64924 (15)	0.2774 (3)	0.0448 (5)
H5A	1.3961	0.6589	0.1681	0.054*
C6	1.27884 (19)	0.65682 (14)	0.3256 (2)	0.0385 (5)
C7	1.1646 (2)	0.68059 (14)	0.1983 (2)	0.0393 (5)
C8	0.95923 (19)	0.75579 (16)	0.1496 (2)	0.0404 (5)
C9	0.9072 (2)	0.58599 (16)	0.1188 (3)	0.0521 (6)
H9A	0.9804	0.5785	0.2071	0.062*
H9B	0.9243	0.5554	0.0218	0.062*
C10	0.7954 (2)	0.53997 (16)	0.1670 (3)	0.0502 (6)
H10A	0.8099	0.4731	0.1782	0.060*
H10B	0.7864	0.5640	0.2729	0.060*
C11	0.6756 (2)	0.55748 (17)	0.0417 (3)	0.0576 (7)
H11A	0.6051	0.5319	0.0813	0.069*
H11B	0.6797	0.5264	−0.0605	0.069*
C12	0.6569 (2)	0.66148 (17)	0.0119 (3)	0.0511 (6)
H12A	0.5826	0.6717	−0.0736	0.061*
H12B	0.6438	0.6914	0.1115	0.061*
C13	0.7685 (2)	0.70500 (17)	−0.0388 (3)	0.0491 (6)
H13A	0.7767	0.6796	−0.1441	0.059*
H13B	0.7559	0.7720	−0.0514	0.059*

Atomic displacement parameters (Ų)

	U11	U22	U33	U12	U13	U23
S1	0.0585 (4)	0.0490 (4)	0.0571 (4)	0.0034 (3)	0.0029 (3)	0.0042 (3)
O1	0.0432 (9)	0.0702 (11)	0.0352 (9)	0.0035 (8)	0.0048 (7)	−0.0055 (7)
N1	0.0350 (10)	0.0584 (11)	0.0305 (9)	0.0052 (9)	0.0028 (7)	−0.0008 (7)
N2	0.0314 (10)	0.0495 (11)	0.0489 (10)	0.0030 (9)	0.0009 (8)	0.0062 (8)
C1	0.0428 (13)	0.0551 (14)	0.0431 (13)	0.0013 (11)	0.0078 (10)	0.0043 (10)
C2	0.0624 (16)	0.0561 (15)	0.0399 (13)	0.0032 (13)	−0.0013 (11)	0.0079 (10)
C3	0.0446 (14)	0.0504 (14)	0.0619 (16)	0.0031 (11)	−0.0136 (12)	0.0039 (11)
C4	0.0352 (13)	0.0545 (15)	0.0653 (16)	0.0000 (11)	0.0044 (11)	−0.0026 (11)
C5	0.0383 (12)	0.0496 (13)	0.0456 (12)	−0.0010 (10)	0.0065 (10)	−0.0002 (10)
C6	0.0341 (12)	0.0411 (11)	0.0387 (11)	−0.0015 (9)	0.0042 (9)	0.0004 (9)
C7	0.0342 (12)	0.0475 (12)	0.0359 (11)	−0.0035 (10)	0.0065 (9)	0.0032 (9)
C8	0.0351 (11)	0.0556 (13)	0.0313 (10)	0.0023 (10)	0.0084 (9)	0.0030 (9)
C9	0.0374 (13)	0.0471 (13)	0.0689 (16)	0.0065 (11)	0.0051 (11)	0.0026 (11)
C10	0.0447 (14)	0.0438 (12)	0.0586 (13)	−0.0018 (11)	0.0033 (11)	0.0000 (10)
C11	0.0454 (14)	0.0603 (15)	0.0625 (15)	−0.0081 (12)	0.0012 (12)	−0.0025 (12)
C12	0.0338 (12)	0.0640 (15)	0.0505 (13)	0.0001 (11)	−0.0027 (10)	−0.0025 (11)
C13	0.0396 (13)	0.0599 (14)	0.0420 (12)	0.0039 (11)	−0.0041 (10)	0.0062 (10)

Geometric parameters (Å, °)

S1—C8	1.667 (2)	C5—C6	1.385 (3)
O1—C7	1.225 (2)	C5—H5A	0.9300
N1—C7	1.364 (3)	C6—C7	1.495 (3)
N1—C8	1.416 (3)	C9—C10	1.514 (3)
N1—H1A	0.8600	C9—H9A	0.9700
N2—C8	1.325 (3)	C9—H9B	0.9700
N2—C13	1.473 (3)	C10—C11	1.511 (3)
N2—C9	1.477 (3)	C10—H10A	0.9700
C1—C6	1.385 (3)	C10—H10B	0.9700
C1—C2	1.388 (3)	C11—C12	1.514 (3)
C1—H1B	0.9300	C11—H11A	0.9700
C2—C3	1.364 (4)	C11—H11B	0.9700
C2—H2A	0.9300	C12—C13	1.506 (3)
C3—C4	1.376 (3)	C12—H12A	0.9700
C3—H3A	0.9300	C12—H12B	0.9700
C4—C5	1.377 (3)	C13—H13A	0.9700
C4—H4A	0.9300	C13—H13B	0.9700
C7—N1—C8	122.74 (17)	N2—C9—C10	111.15 (18)
C7—N1—H1A	118.6	N2—C9—H9A	109.4
C8—N1—H1A	118.6	C10—C9—H9A	109.4
C8—N2—C13	121.05 (18)	N2—C9—H9B	109.4
C8—N2—C9	125.68 (18)	C10—C9—H9B	109.4
C13—N2—C9	113.22 (18)	H9A—C9—H9B	108.0
C6—C1—C2	119.6 (2)	C11—C10—C9	111.9 (2)
C6—C1—H1B	120.2	C11—C10—H10A	109.2
C2—C1—H1B	120.2	C9—C10—H10A	109.2
C3—C2—C1	120.2 (2)	C11—C10—H10B	109.2
C3—C2—H2A	119.9	C9—C10—H10B	109.2
C1—C2—H2A	119.9	H10A—C10—H10B	107.9
C2—C3—C4	120.5 (2)	C10—C11—C12	110.07 (19)
C2—C3—H3A	119.7	C10—C11—H11A	109.6
C4—C3—H3A	119.7	C12—C11—H11A	109.6
C3—C4—C5	119.9 (2)	C10—C11—H11B	109.6
C3—C4—H4A	120.0	C12—C11—H11B	109.6
C5—C4—H4A	120.0	H11A—C11—H11B	108.2
C4—C5—C6	120.1 (2)	C13—C12—C11	111.2 (2)
C4—C5—H5A	120.0	C13—C12—H12A	109.4
C6—C5—H5A	120.0	C11—C12—H12A	109.4
C1—C6—C5	119.7 (2)	C13—C12—H12B	109.4
C1—C6—C7	121.89 (19)	C11—C12—H12B	109.4
C5—C6—C7	118.43 (18)	H12A—C12—H12B	108.0
O1—C7—N1	122.59 (19)	N2—C13—C12	110.88 (18)
O1—C7—C6	121.86 (19)	N2—C13—H13A	109.5
N1—C7—C6	115.56 (17)	C12—C13—H13A	109.5
N2—C8—N1	115.66 (19)	N2—C13—H13B	109.5
N2—C8—S1	126.36 (16)	C12—C13—H13B	109.5
N1—C8—S1	117.96 (16)	H13A—C13—H13B	108.1
C6—C1—C2—C3	−1.0 (3)	C13—N2—C8—N1	−173.80 (17)
C1—C2—C3—C4	−0.3 (4)	C9—N2—C8—N1	3.5 (3)
C2—C3—C4—C5	0.5 (3)	C13—N2—C8—S1	7.6 (3)
C3—C4—C5—C6	0.7 (3)	C9—N2—C8—S1	−175.12 (16)
C2—C1—C6—C5	2.2 (3)	C7—N1—C8—N2	65.2 (3)
C2—C1—C6—C7	−179.9 (2)	C7—N1—C8—S1	−116.00 (19)
C4—C5—C6—C1	−2.0 (3)	C8—N2—C9—C10	128.2 (2)
C4—C5—C6—C7	179.98 (19)	C13—N2—C9—C10	−54.3 (2)
C8—N1—C7—O1	0.5 (3)	N2—C9—C10—C11	53.4 (3)
C8—N1—C7—C6	−179.52 (18)	C9—C10—C11—C12	−54.2 (3)
C1—C6—C7—O1	−148.6 (2)	C10—C11—C12—C13	55.5 (3)
C5—C6—C7—O1	29.4 (3)	C8—N2—C13—C12	−126.5 (2)
C1—C6—C7—N1	31.4 (3)	C9—N2—C13—C12	55.8 (2)
C5—C6—C7—N1	−150.61 (19)	C11—C12—C13—N2	−56.1 (3)

Hydrogen-bond geometry (Å, °)

D—H···A	D—H	H···A	D···A	D—H···A
N1—H1A···O1i	0.86	2.18	2.949 (2)	149

Symmetry codes: (i) x, −y+3/2, z+1/2.