Table 2.
Toxicity | Grade 1 | Grade 2 | Grade 3 | Grade 4 | Grade 5 |
---|---|---|---|---|---|
N = 77 | Number (%) | Number (%) | Number (%) | Number (%) | Number (%) |
Leukocytes (Total WBC) | 5 (6%) | 18 (23%) | 27 (35%) | 23 (30%) | 0 |
Neutrophils | 4 (5%) | 2(3%) | 14 (18%) | 39 (51%) | 0 |
Platelets | 27 (35%) | 5 (6%) | 2 (3%) | 1 (1%) | 0 |
Febrile Neutropenia | 0 (0%) | 0 (0%) | 2 (3%) | 1 (1%) | 0 |
Documented Infections | 0 (0%) | 0 (0%) | 8 (10%) | 0 (0%) | 0 |
Infection without neutropenia | 2 (3%) | 13 (17%) | 3 (4%) | 0 (0%) | 1 (1%) |
Cardiac Arrhythmia | 3 (4%) | 0 (0%) | 5 (6%) | 1 (1%) | 0 |
Edema | 20 (26%) | 10 (13%) | 3 (4%) | 0 (0%) | 0 |
Hypertension | 8 (10%) | 1 (1%) | 3 (4%) | 1 (1%) | 0 |
Hypotension | 0 (0%) | 2 (3%) | 2 (3%) | 0 (0%) | 0 |
PT Prolongation | 7 (9%) | 6 (8%) | 6 (8%) | 0 (0%) | 0 |
Fatigue | 15 (19%) | 36 (47%) | 15 (19%) | 4 (5%) | 0 |
Anorexia | 16 (21%) | 20 (26%) | 2 (3%) | 0 (0%) | 0 |
Colitis | 0 (0%) | 1 (1%) | 0 (0%) | 1 (1%) | 0 |
Constipation | 15 (19%) | 13 (17%) | 3 (4%) | 0 (0%) | 0 |
Diarrhea | 21 (27%) | 15 (19%) | 5 (6%) | 0 (0%) | 0 |
Dehydration | 2 (3%) | 4 (5%) | 2 (3%) | 0 (0%) | 0 |
Ileus/Obstruction | 0 (0%) | 0 (0%) | 4 (5%) | 0 (0%) | 0 |
Stomatitis/Mucositis | 11 (14%) | 16 (21%) | 3 (4%) | 0 (0%) | 0 |
Nausea | 32 (42%) | 13 (17%) | 4 (5%) | 0 (0%) | 0 |
Epistaxis | 32 (42%) | 0 (0%) | 1 (1%) | 0 (0%) | 0 |
Hemorrhage | 6 (8%) | 0 (0%) | 1 (1%) | 0 (0%) | 0 |
Melana/GI bleed | 0 (0%) | 0 (0%) | 2 (3%) | 0 (0%) | 0 |
Transaminase (AST) | 5 (6%) | 3 (4%) | 3 (4%) | 0 (0%) | 0 |
Acidosis | 0 (0%) | 0 (0%) | 0 (0%) | 0 (0%) | 1 (1%) |
Hypoalbuminemia | 20 (26%) | 10 (13%) | 3 (4%) | 0 (0%) | 0 |
Hyperglycemia | 11 (14%) | 15 (19%) | 3 (4%) | 1 (1%) | 0 |
Hypokalemia | 6 (8%) | 0 (0%) | 2 (3%) | 1 (1%) | 0 |
Hyponatremia | 13 (17%) | 0 (0%) | 5 (6%) | 0 (0%) | 0 |
CNS Ischemia | 0 (0%) | 0 (0%) | 1 (1%) | 1 (1%) | 0 |
CNS Hemorrhage/Bleed | 0 (0%) | 0 (0%) | 1 (1%) | 0 (0%) | 0 |
Mood alteration | 8 (10%) | 3 (4%) | 3 (4%) | 0 (0%) | 0 |
Neuropathy | 20 (26%) | 14 (18%) | 4 (5%) | 0 (0%) | 0 |
Syncope | 0 (0%) | 0 (0%) | 4 (5%) | 0 (0%) | 0 |
Bone pain | 1 (1%) | 8 (10%) | 4 (5%) | 0 (0%) | 0 |
Neuropathic pain | 1 (1%) | 1 (1%) | 0 (0%) | 1 (1%) | 0 |
Pain | 7 (9%) | 16 (21%) | 11 (14%) | 0 (0%) | 0 |
Cough | 11 (14%) | 1 (1%) | 3 (4%) | 0 (0%) | 0 |
Dyspnea | 0 (0%) | 13 (17%) | 3 (4%) | 3 (4%) | 0 |
Proteinuria | 11 (14%) | 5 (6%) | 1 (1%) | 0 (0%) | 0 |
Thrombosis/Embolism | 0 (0%) | 0 (0%) | 4 (5%) | 2 (3%) | 1 (1%) |