FIG. 1.

Comparison of copy number variants between blood- and cell line-derived DNA. To compare the differences between blood- and cell line-derived DNA, we analyzed a well-characterized CNV in the amylase gene. Calculated copy numbers of the AMY2A gene in blood-derived (left) and cell line-derived (right) DNA samples are shown. Each dot represents the copy number of each individual sample. The area between the horizontal black bars represents the range of values that constitutes two copies. Gray-shaded regions signify borderline values that cannot be clearly assigned, either a one or two copies (lower region) or a two or three copies (upper region). Samples that fell in these gray areas were excluded from analysis. DNA samples derived from cell lines showed a significant increase in the number of samples showing deletions compared to those derived from whole blood (p = 0.008).