SUMMARY
60 Schizophrenic patients were given LiCo3/Chlorpromazine for 4 weeks, in a double blind cross over study with two placebo crossovers of 1 week before and two weeks after active treatment. Several core schizophrenic features showed significant reduction in severity with lithium. However, CPZ treatment was superior in terms of improvement, as compared to the other group on MBPRS and CGIS. Target symptoms may be one situation, where lithium could be tried and these results are discussed.
Full Text
The Full Text of this article is available as a PDF (273.2 KB).
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Alexander P. E., van Kammen D. P., Bunney W. E., Jr Antipsychotic effects of lithium in schizophrenia. Am J Psychiatry. 1979 Mar;136(3):283–287. doi: 10.1176/ajp.136.3.283. [DOI] [PubMed] [Google Scholar]
- CADE J. F. J. Lithium salts in the treatment of psychotic excitement. Med J Aust. 1949 Sep 3;2(10):349–352. doi: 10.1080/j.1440-1614.1999.06241.x. [DOI] [PubMed] [Google Scholar]
- CARRERE J., POCHARD Le citrate de lithium dans le traitement des syndromes d'excitation psychomotrice. Ann Med Psychol (Paris) 1954 Apr;112(1 4):566–572. [PubMed] [Google Scholar]
- GERSHON S., YUWILER A. Lithium ion: a specific psychopharmacological approach to the treatment of mania. J Neuropsychiatr. 1960 May-Jun;1:229–241. [PubMed] [Google Scholar]
- Gjessing L. R. Lithium citrate loading of a patient with periodic catatonia. Acta Psychiatr Scand. 1967;43(4):372–375. doi: 10.1111/j.1600-0447.1967.tb05774.x. [DOI] [PubMed] [Google Scholar]
- Gram L. F., Rafaelsen O. J. Lithium treatment of psychotic children and adolescents. A controlled clinical trial. Acta Psychiatr Scand. 1972;48(3):253–260. doi: 10.1111/j.1600-0447.1972.tb04366.x. [DOI] [PubMed] [Google Scholar]
- Growe G. A., Crayton J. W., Klass D. B., Evans H., Strizich M. Lithium in chronic schizophrenia. Am J Psychiatry. 1979 Apr;136(4A):454–455. [PubMed] [Google Scholar]
- Hekimian L. J., Gershon S., Hardesty A. S., Burdock E. I. Drug efficacy and diagnostic specificity in manic depressive illness and schizophrenia. Dis Nerv Syst. 1969 Nov;30(11):747–751. [PubMed] [Google Scholar]
- Hollister L. E. Mental disorders--antipsychotic and antimanic drugs. N Engl J Med. 1972 May 4;286(18):984–987. doi: 10.1056/NEJM197205042861806. [DOI] [PubMed] [Google Scholar]
- Johnson G. Differential response to lithium carbonate in manic depressive and schizo-affective disorders. Dis Nerv Syst. 1970 Sep;31(9):613–615. [PubMed] [Google Scholar]
- Klawans H. L., Weiner W. J., Nausieda P. A. The effect of lithium on an animal model of tardive dyskinesia. Prog Neuropsychopharmacol. 1977;1(1-2):53–60. doi: 10.1016/0364-7722(77)90027-3. [DOI] [PubMed] [Google Scholar]
- Liebowitz J. H., Rudy V., Gershon E. S., Gillis A. A pharmacogenetic case report: lithium-responsive postpsychotic antisocial behavior. Compr Psychiatry. 1976 Sep-Oct;17(5):655–660. doi: 10.1016/s0010-440x(76)80010-7. [DOI] [PubMed] [Google Scholar]
- MARGULIES M. Suggestions for the treatment of schizophrenic and manic-depressive patients. Med J Aust. 1955 Jan 29;42(1 5):137–141. [PubMed] [Google Scholar]
- Martorano J. T. Target symptoms in lithium carbonate therapy. Compr Psychiatry. 1972 Nov-Dec;13(6):533–537. doi: 10.1016/0010-440x(72)90053-3. [DOI] [PubMed] [Google Scholar]
- Petursson H. Lithium treatment of a patient with periodic catatonia. Acta Psychiatr Scand. 1976 Oct;54(4):248–253. doi: 10.1111/j.1600-0447.1976.tb00118.x. [DOI] [PubMed] [Google Scholar]
- Prien R. F., Caffey E. M., Jr, Klett C. J. A comparison of lithium carbonate and chlorpromazine in the treatment of excited schizo-affectives. Report of the Veterans Administration and National Institute of Mental Health collaborative study group. Arch Gen Psychiatry. 1972 Aug;27(2):182–189. doi: 10.1001/archpsyc.1972.01750260034005. [DOI] [PubMed] [Google Scholar]
- RICE D. The use of lithium salts in the treatment of manic states. J Ment Sci. 1956 Jul;102(428):604–611. doi: 10.1192/bjp.102.428.604. [DOI] [PubMed] [Google Scholar]
- Shopsin B., Kim S. S., Gershon S. A controlled study of lithium vs. chlorpromazine in acute schizophrenics. Br J Psychiatry. 1971 Oct;119(551):435–440. doi: 10.1192/bjp.119.551.435. [DOI] [PubMed] [Google Scholar]
- Sikes J. C., Sikes S. C. Lithium carbonate treatment in psychiatry. Dis Nerv Syst. 1970 Jan;31(1):52–55. [PubMed] [Google Scholar]
- Small J. G., Kellams J. J., Milstein V., Moore J. A placebo-controlled study of lithium combined with neuroleptics in chronic schizophrenic patients. Am J Psychiatry. 1975 Dec;132(12):1315–1317. doi: 10.1176/ajp.132.12.1315. [DOI] [PubMed] [Google Scholar]
- Takahashi S., Gjessing L. R. Studies of periodic catatonia. IV. Longitudinal study of catecholamine metabolism, with and without drugs. J Psychiatr Res. 1972 Dec;9(4):293–314. doi: 10.1016/0022-3956(72)90027-1. [DOI] [PubMed] [Google Scholar]
- Tupin J. P., Smith D. B., Clanon T. L., Kim L. I., Nugent A., Groupe A. The long-term use of lithium in aggressive prisoners. Compr Psychiatry. 1973 Jul-Aug;14(4):311–317. doi: 10.1016/0010-440x(73)90022-9. [DOI] [PubMed] [Google Scholar]
- Van Putten T., Sanders D. G. Lithium in treatment failures. J Nerv Ment Dis. 1975 Oct;161(4):255–264. doi: 10.1097/00005053-197510000-00005. [DOI] [PubMed] [Google Scholar]
- Wald D., Lerner J. Lithium in the treatment of periodic catatonia: a case report. Am J Psychiatry. 1978 Jun;135(6):751–752. doi: 10.1176/ajp.135.6.751. [DOI] [PubMed] [Google Scholar]
- Zall H., Therman P. G., Myers J. M. Lithium carbonate: a clinical study. Am J Psychiatry. 1968 Oct;125(4):549–555. doi: 10.1176/ajp.125.4.549. [DOI] [PubMed] [Google Scholar]