Skip to main content
Indian Journal of Psychiatry logoLink to Indian Journal of Psychiatry
. 1980 Apr-Jun;22(2):142–150.

SEX CHROMOSOME ABERRATIONS IN SCHIZOPHRENIA

S B Chatterjee 1, S K Basu 2
PMCID: PMC3013302  PMID: 22058457

SUMMARY

Research on sex chromosome aberrations has made considerable progress. There are evidences that possession of an extra X chromosome may affect the mental health of an individual. All the male schizophrenia patients registered during the period of study, who were not under treatment, constituted the patient sample. They numbered two hundered eighty seven. A properly matched control sample of two hundred thirty three healthy persons was also examined. Nuclear sexing and Karyotype was done for (a) all the chromatin positive cases in patient as well as control sample (b) ten per cent cases of normal XY individual's of patient sample(28) and control sample (23) Photography was done for the positive slides. The patients who showed chromation positive XXY pattern were studied further clinically along with Rorschach test and Bhatia battery. The schizophrenics showed more prevalence of chromatin positive than the control sample.

Full Text

The Full Text of this article is available as a PDF (291.2 KB).

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Brown W. M. Males with an XYY sex chromosome complement. J Med Genet. 1968 Dec;5(4):341–359. doi: 10.1136/jmg.5.4.341. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. CARR D. H., BARR M. L., PLUNKETT E. R. A probable XXYY sex determining mechanism in a mentally defective male with Klinefelter's syndrome. Can Med Assoc J. 1961 Apr 22;84:873–878. [PMC free article] [PubMed] [Google Scholar]
  3. HOSKINS R. G., PINCUS G. Sex-hormone relationships in schizophrenic men. Psychosom Med. 1949 Mar–Apr;11(2):102–109. doi: 10.1097/00006842-194903000-00003. [DOI] [PubMed] [Google Scholar]
  4. Maclean N., Brown W. M., Jacobs P. A., Mantle D. J., Strong J. A. A survey of sex chromatin abnormalities in mental hospitals. J Med Genet. 1968 Sep;5(3):165–172. doi: 10.1136/jmg.5.3.165. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Olanders S. Double barr Bodies in women in mental hospitals. Br J Psychiatry. 1967 Oct;113(503):1097–1099. doi: 10.1192/bjp.113.503.1097. [DOI] [PubMed] [Google Scholar]
  6. Olanders S. Excess Barr bodies in patients in mental hospitals. Lancet. 1968 Dec 7;2(7580):1244–1244. doi: 10.1016/s0140-6736(68)91725-x. [DOI] [PubMed] [Google Scholar]
  7. RAPHAEL T., SHAW M. W. Chromosome studies in schizophrenia. JAMA. 1963 Mar 23;183:1022–1028. doi: 10.1001/jama.1963.63700120025010. [DOI] [PubMed] [Google Scholar]
  8. TEDESCHI L. G., FREEMAN H. Sex chromosomes in male schizophrenics. Arch Gen Psychiatry. 1962 Feb;6:109–111. doi: 10.1001/archpsyc.1962.01710200001001. [DOI] [PubMed] [Google Scholar]

Articles from Indian Journal of Psychiatry are provided here courtesy of Wolters Kluwer -- Medknow Publications

RESOURCES