SUMMARY
The authors report four cases of Monopolar Depressed patients who developed manic features for the first time while on tricyclic antidepressant therapy. The phenomenon is viewed as tricyclic antidepressant induced mania. The manic symptoms occurred late in therapy, with moderate doses of tricyclic antidepressants (125-150 mg per day) and were easily controlled with antipsychotic medication. Factors relating to age of patients, metabolic products of tricyclic antidepressants and central nor-adrenergic and dopaminergic systems are considered important and their role has been discussed.
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Selected References
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- Bevan P., Bradshaw C. M., Szabadi E. Effects of desipramine on neuronal responses to dopamine, noradrenaline, 5-hydroxytryptamine and acetylcholine in the caudate nucleus of the rat. Br J Pharmacol. 1975 Jul;54(3):285–293. doi: 10.1111/j.1476-5381.1975.tb07567.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Bunney W. E., Jr, Goodwin F. K., Murphy D. L., House K. M., Gordon E. K. The "switch process" in manic-depressive illness. II. Relationship to catecholamines, REM sleep, and drugs. Arch Gen Psychiatry. 1972 Sep;27(3):304–309. doi: 10.1001/archpsyc.1972.01750270014002. [DOI] [PubMed] [Google Scholar]
- Carlsson A., Corrodi H., Fuxe K., Hökfelt T. Effect of antidepressant drugs on the depletion of intraneuronal brain 5-hydroxytryptamine stores caused by 4-methyl-alpha-ethyl-meta-tyramine. Eur J Pharmacol. 1969 Mar;5(4):357–366. doi: 10.1016/0014-2999(69)90113-7. [DOI] [PubMed] [Google Scholar]
- Gerner R. H., Post R. M., Bunney W. E., Jr A dopaminergic mechanism in mania. Am J Psychiatry. 1976 Oct;133(10):1177–1180. doi: 10.1176/ajp.133.10.1177. [DOI] [PubMed] [Google Scholar]
- Grabowska M., Antikiewicz L., Michaluk J. The influence of the tricyclic antidepressants on the apomorphine induced hypermotility in rats. Pol J Pharmacol Pharm. 1974 Jul-Aug;26(4):411–417. [PubMed] [Google Scholar]
- HAMILTON M. A rating scale for depression. J Neurol Neurosurg Psychiatry. 1960 Feb;23:56–62. doi: 10.1136/jnnp.23.1.56. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Halaris A. E., Belendiuk K. T., Freedman D. X. Antidepressant drugs affect dopamine uptake. Biochem Pharmacol. 1975 Oct 15;24(20):1896–1897. doi: 10.1016/0006-2952(75)90412-8. [DOI] [PubMed] [Google Scholar]
- Hyttel J. Neurochemical characterization of a new potent and selective serotonin uptake inhibitor: Lu 10-171. Psychopharmacology (Berl) 1977 Mar 16;51(3):225–233. doi: 10.1007/BF00431629. [DOI] [PubMed] [Google Scholar]
- Meek J., Werdinus B. Hydroxytryptamine turnover decreased by the antidepressant drug chlorimipramine. J Pharm Pharmacol. 1970 Feb;22(2):141–143. doi: 10.1111/j.2042-7158.1970.tb08412.x. [DOI] [PubMed] [Google Scholar]
- U'Prichard D. C., Greenberg D. A., Sheehan P. P., Snyder S. H. Tricyclic antidepressants: therapeutic properties and affinity for alpha-noradrenergic receptor binding sites in the brain. Science. 1978 Jan 13;199(4325):197–198. doi: 10.1126/science.202024. [DOI] [PubMed] [Google Scholar]
- WAGENSOMMER J. THERAPEUTISCH UNERWUENSCHTE WIRKUNGEN DER THYMOLEPTIKA. Fortschr Neurol Psychiatr Grenzgeb. 1964 Oct;32:497–512. [PubMed] [Google Scholar]
- van Scheyen J. D., van Kammen D. P. Clomipramine-induced mania in unipolar depression. Arch Gen Psychiatry. 1979 May;36(5):560–565. doi: 10.1001/archpsyc.1979.01780050070008. [DOI] [PubMed] [Google Scholar]