Skip to main content
NCBI home page
The Journal of Clinical Investigation logoLink to The Journal of Clinical Investigation
. 1974 Feb;53(2):501–507. doi: 10.1172/JCI107583

Proximal tubule reabsorption after hyperoncotic albumin infusion. Role of parathyroid hormone and dissociation from plasma volume.

F G Knox 1, E G Schneider 1, L R Willis 1, J W Strandhoy 1, C E Ott 1, J L Cuche 1, R S Goldsmith 1, C D Arnaud 1
PMCID: PMC301492  PMID: 11344563

Abstract

Preferential expansion of the plasma volume by infusion of salt-poor hyperoncotic albumin solution decreases sodium reabsorption by the proximal tubule. The present micropuncture studies test the thesis that albumin infusion depresses proximal reabsorption by an effect unrelated to expansion of the plasma volume, perhaps due to an effect of parathyroid hormone (PTH) on proximal sodium reabsorption. Infusion of salt-poor hyperoncotic albumin significantly decreased plasma ionized calcium, increased immunoreactive PTH (iPTH) in plasma, decreased sodium reabsorption by the proximal tubule, and increased phosphate clearance. In contrast, infusions of albumin, in which the ionized calcium was restored to normal plasma levels, had no significant effect on ionized calcium, iPTH, proximal reabsorption, or phosphate clearance in intact dogs. Similarly, in parathyroidectomized animals given a constant replacement infusion of PTH, albumin infusion had no significant effect on proximal reabsorption or phosphate clearance. Plasma volume was markedly expanded following albumin infusion in all groups of dogs. These findings (a) indicate that PTH plays a significant role in the decrease in sodium reabsorption by the renal proximal tubule after salt-poor hyperoncotic albumin infusion, and (b) dissociate preferential expansion of the plasma volume from decreases in sodium reabsorption by the proximal tubule.

Full text

PDF
501

Images in this article

503Image
on p.503

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Agus Z. S., Gardner L. B., Beck L. H., Goldberg M. Effects of parathyroid hormone on renal tubular reabsorption of calcium, sodium, and phosphate. Am J Physiol. 1973 May;224(5):1143–1148. doi: 10.1152/ajplegacy.1973.224.5.1143. [DOI] [PubMed] [Google Scholar]
  2. Agus Z. S., Puschett J. B., Senesky D., Goldberg M. Mode of action of parathyroid hormone and cyclic adenosine 3',5'-monophosphate on renal tubular phosphate reabsorption in the dog. J Clin Invest. 1971 Mar;50(3):617–626. doi: 10.1172/JCI106532. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Arnaud C. D., Tsao H. S., Littledike T. Radioimmunoassay of human parathyroid hormone in serum. J Clin Invest. 1971 Jan;50(1):21–34. doi: 10.1172/JCI106476. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Beck L. H., Goldberg M. Effects of acetazolamide and parathyroidectomy on renal transport of sodium, calcium, and phosphate. Am J Physiol. 1973 May;224(5):1136–1142. doi: 10.1152/ajplegacy.1973.224.5.1136. [DOI] [PubMed] [Google Scholar]
  5. DIRKS J. H., CIRKSENA W. J., BERLINER R. W. THE EFFECTS OF SALINE INFUSION ON SODIUM REABSORPTION BY THE PROXIMAL TUBULE OF THE DOG. J Clin Invest. 1965 Jul;44:1160–1170. doi: 10.1172/JCI105223. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Daugharty T. M., Ueki I. F., Nicholas D. P., Brenner B. M. Comparative renal effects of isoncotic and colloid-free volume expansion in the rat. Am J Physiol. 1972 Jan;222(1):225–235. doi: 10.1152/ajplegacy.1972.222.1.225. [DOI] [PubMed] [Google Scholar]
  7. Dresser T. P., Lynch R. E., Schneider E. G., Knox F. G. Effect of increases in blood pressure on pressure and reabsorption in the proximal tubule. Am J Physiol. 1971 Feb;220(2):444–447. doi: 10.1152/ajplegacy.1971.220.2.444. [DOI] [PubMed] [Google Scholar]
  8. Fjeldbo W., Stamey T. A. Adapted method for determination of inulin in serum and urine with an AutoAnalyzer. J Lab Clin Med. 1968 Aug;72(2):353–358. [PubMed] [Google Scholar]
  9. HARVEY R. B., BROTHERS A. J. Renal extraction of para-aminohippurate and creatinine measured by continuous in vivo sampling of arterial and renal-vein blood. Ann N Y Acad Sci. 1962 Oct 31;102:46–54. doi: 10.1111/j.1749-6632.1962.tb13624.x. [DOI] [PubMed] [Google Scholar]
  10. Howards S. S., Davis B. B., Knox F. G., Wright F. S., Berliner R. W. Depression of fractional sodium reabsorption by the proximal tubule of the dog without sodium diuresis. J Clin Invest. 1968 Jul;47(7):1561–1572. doi: 10.1172/JCI105848. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Knox F. G., Howards S. S., Wright F. S., Davis B. B., Berliner R. W. Effect of dilution and expansion of blood volume on proximal sodium reabsorption. Am J Physiol. 1968 Nov;215(5):1041–1048. doi: 10.1152/ajplegacy.1968.215.5.1041. [DOI] [PubMed] [Google Scholar]
  12. Knox F. G., Willis L. R., Strandhoy J. W., Schneider E. G., Navar L. G., Ott C. E. Role of peritubule Starling forces in proximal reabsorption following albumin infusion. Am J Physiol. 1972 Oct;223(4):741–749. doi: 10.1152/ajplegacy.1972.223.4.741. [DOI] [PubMed] [Google Scholar]
  13. Koch K. M., Aynedjian H. S., Bank N. Effect of acute hypertension on sodium reabsorption by the proximal tubule. J Clin Invest. 1968 Jul;47(7):1696–1709. doi: 10.1172/JCI105860. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Li T. K., Piechocki J. T. Determination of serum ionic calcium with an ion-selective electrode: evaluation of methodology and normal values. Clin Chem. 1971 May;17(5):411–416. [PubMed] [Google Scholar]
  15. Moore E. W. Ionized calcium in normal serum, ultrafiltrates, and whole blood determined by ion-exchange electrodes. J Clin Invest. 1970 Feb;49(2):318–334. doi: 10.1172/JCI106241. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Schneider E. G., Lynch R. E., Willis L. R., Knox F. G. Single-nephron filtration rate in the dog. Am J Physiol. 1972 Mar;222(3):667–673. doi: 10.1152/ajplegacy.1972.222.3.667. [DOI] [PubMed] [Google Scholar]
  17. Sonnenberg H. Renal response to blood volume expansion: distal tubular function and urinary excretion. Am J Physiol. 1972 Oct;223(4):916–924. doi: 10.1152/ajplegacy.1972.223.4.916. [DOI] [PubMed] [Google Scholar]
  18. Sonnenberg H. The renal response to blood volume expansion in the rat: proximal tubular function and urinary excretion. Can J Physiol Pharmacol. 1971 Jun;49(6):525–535. doi: 10.1139/y71-068. [DOI] [PubMed] [Google Scholar]
  19. Stote R. M., Smith L. H., Wilson D. M., Dube W. J., Goldsmith R. S., Arnaud C. D. Hydrochlorothiazide effects on serum calcim and immunoreactive parathyroid hormone concentrations. Studies in normal subjects. Ann Intern Med. 1972 Oct;77(4):587–591. doi: 10.7326/0003-4819-77-4-587. [DOI] [PubMed] [Google Scholar]
  20. Watson J. F. Effect of saline loading on sodium reabsorption in the dog proximal tubule. Am J Physiol. 1966 Apr;210(4):781–785. doi: 10.1152/ajplegacy.1966.210.4.781. [DOI] [PubMed] [Google Scholar]
  21. Young D. S. Improved method for the automatic determination of serum inorganic phosphate. J Clin Pathol. 1966 Jul;19(4):397–399. doi: 10.1136/jcp.19.4.397. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Journal of Clinical Investigation are provided here courtesy of American Society for Clinical Investigation

RESOURCES