Figure 4.
p38 activation suppressed anti-CD3 activated T (Ttcr) cell proliferation. CFSE-labelled Ttcr cells were differentiated in the presence or absence of SB202190. (a) Proliferation of CFSE-labelled Ttcr ± SB202190 after 8-day culture. A representative of four experiments is shown. (b, c) Proliferation and apoptosis of Ttcr ± SB202190 over 8 days. (d) Proportion of Ttcr cells entered into S and G2 phases of cell cycle at indicated days. (e) The day 8 cell number in Ttcr ± SB202190 cultures.