Table 2.
Principal phenotype
| Cases |
Controls |
Genotype association |
Allele association |
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Gene | SNP | Total | % failed | Freq | Total | % failed | Freq | χ2 2df | χ2 p Value | Odds ratio | χ2 1df | χ2 p Value | |
| A | GMCSF | rs7727544 | 415 | 5.80 | 0.40 | 576 | 13.0 | 0.45 | 6.56 | 0.038 | 0.83 (0.69–1.01) | 3.61 | 0.058 |
| SLC22A5 | rs274549 | 415 | 2.70 | 0.18 | 576 | 2.6 | 0.13 | 8.20 | 0.017 | 1.39 (1.08–1.79) | 6.43 | 0.011 | |
| SLC22A5 | rs14701 | 415 | 1.4 | 0.18 | 576 | 3.6 | 0.13 | 11.69 | 0.003 | 1.46 (1.13–1.87) | 8.32 | 0.004 | |
| IL13 | rs1800925 | 415 | 1.9 | 0.18 | 576 | 4.9 | 0.21 | 2.14 | 0.343 | 0.85 (0.67–1.07) | 1.79 | 0.181 | |
| IL13 | rs1295686 | 415 | 1.4 | 0.19 | 576 | 2.6 | 0.18 | 0.48 | 0.788 | 1.08 (0.86–1.36) | 0.37 | 0.544 | |
| IL13 | rs20541 | 415 | 0.2 | 0.18 | 576 | 6.8 | 0.15 | 3.46 | 0.177 | 1.25 (0.98–1.59) | 3.04 | 0.081 | |
| CNS-1 | rs2243302 | 415 | 1.45 | 0.11 | 576 | 2.78 | 0.13 | 2.39 | 0.303 | 0.8 (0.61–1.06) | 2.19 | 0.139 | |
| IL4 | rs2243250 | 415 | 4.8 | 0.14 | 576 | 5.2 | 0.11 | 5.99 | 0.050 | 1.30 (0.99–1.71) | 3.36 | 0.067 | |
| IL4 | rs2070874 | 415 | 3.6 | 0.15 | 576 | 6.8 | 0.12 | 8.87 | 0.012 | 1.32 (1.01–1.72) | 3.87 | 0.049 | |
| IL4 | rs734244 | 415 | 5.1 | 0.15 | 576 | 5.2 | 0.12 | 6.34 | 0.042 | 1.31 (1.00–1.72) | 3.62 | 0.057 | |
| IL4 | rs2227284 | 415 | 3.9 | 0.27 | 576 | 8.2 | 0.22 | 5.09 | 0.078 | 1.27 (1.03–1.58) | 4.85 | 0.028 | |
| IL4 | rs2243268 | 413 | 1.0 | 0.15 | 576 | 2.1 | 0.12 | 3.27 | 0.195 | 1.26 (0.97–1.64) | 2.82 | 0.093 | |
| IL4 | rs2243270 | 415 | 3.4 | 0.16 | 576 | 4.7 | 0.13 | 7.55 | 0.023 | 1.34 (1.03–1.73) | 4.58 | 0.032 | |
| B | SLC22A5 | rs14701 | 780 | 3.1 | 0.17 | 1045 | 3.6 | 0.14 | 7.52 | 0.023 | 1.21 (1.01–1.45) | 3.91 | 0.048 |
| IL13 | rs1800925 | 780 | 1.9 | 0.18 | 1045 | 3.4 | 0.19 | 0.45 | 0.800 | 0.96 (0.81–1.14) | 0.19 | 0.665 | |
| IL13 | rs1295686 | 780 | 1.2 | 0.20 | 1045 | 1.9 | 0.18 | 3.00 | 0.223 | 1.15 (0.97–1.36) | 2.59 | 0.108 | |
| IL13 | rs20541 | 782 | 3.6 | 0.19 | 1045 | 6.1 | 0.16 | 5.14 | 0.077 | 1.23 (1.03–1.46) | 4.92 | 0.027 | |
| IL4 | rs2243250 | 780 | 3.3 | 0.15 | 1044 | 3.9 | 0.13 | 4.42 | 0.110 | 1.22 (1.00–1.48) | 3.75 | 0.053 | |
| IL4 | rs2070874 | 779 | 3.0 | 0.15 | 1045 | 4.2 | 0.13 | 3.95 | 0.139 | 1.18 (0.98–1.43) | 2.83 | 0.092 | |
| IL4 | rs2243270 | 780 | 5.1 | 0.16 | 1045 | 4.7 | 0.14 | 3.58 | 0.167 | 1.18 (0.97–1.42) | 2.69 | 0.101 | |
Single SNP association statistics for all SNPs with positive findings and those used in haplotype analysis: (A) Cohort 1. (B) Total cohort. Association statistics for all 48 htSNPs genotyped in cohort 1 are available in table 2A in the online supplement.
Freq, frequency.