. Author manuscript; available in PMC: 2011 Jan 5.

Published in final edited form as: Thorax. 2009 Jan 8;64(4):345–352. doi: 10.1136/thx.2008.102111

Table 3.

Refined phenotype

			Cases			Controls			Genotype association		Allele association
	Gene	SNP	Total	% failed	Freq	Total	% failed	Freq	χ² 2df	χ² p Value	Odds ratio	χ² 1df	χ² p Value
A	GMCSF	rs7727544	218	6.9	0.41	576	13.0	0.45	1.68	0.432	0.85 (0.68–1.08)	1.61	0.205
	SLC22A5	rs274549	218	2.8	0.17	576	2.6	0.13	2.92	0.232	1.29 (0.95–1.76)	2.38	0.123
	SLC22A5	rs14701	218	1.4	0.16	576	3.6	0.13	4.24	0.120	1.31 (0.96–1.79)	2.72	0.099
	IL13	rs1800925	218	2.3	0.17	576	4.9	0.21	3.47	0.176	0.78 (0.59–1.05)	2.46	0.117
	IL13	rs1295686	218	1.4	0.19	576	2.6	0.18	0.17	0.920	1.06 (0.8–1.41)	0.09	0.759
	IL13	rs20541	218	0.5	0.18	576	6.8	0.15	1.65	0.439	1.21 (0.9–1.62)	1.37	0.242
	CNS-1	rs2243302	218	2.3	0.09	576	2.8	0.13	5.34	0.069	0.66 (0.46–0.96)	4.41	0.036
	IL4	rs2243250	218	3.7	0.17	576	5.2	0.11	11.77	0.003	1.64 (1.2–2.25)	9.19	0.002
	IL4	rs2070874	218	2.3	0.17	576	6.8	0.12	10.52	0.005	1.54 (1.13–2.1)	7.04	0.008
	IL4	rs734244	218	7.3	0.17	576	5.2	0.12	8.26	0.016	1.54 (1.12–2.12)	6.59	0.010
	IL4	rs2227284	218	5.5	0.28	576	8.2	0.22	7.49	0.024	1.37 (1.06–1.78)	5.51	0.019
	IL4	rs2243268	218	0.5	0.17	576	2.1	0.12	5.55	0.062	1.43 (1.05–1.94)	4.81	0.028
	IL4	rs2243270	218	4.6	0.19	576	4.7	0.13	12.19	0.002	1.6 (1.19–2.17)	9.00	0.003
B	SLC22A5	rs14701	408	2.9	0.17	1045	3.6	0.14	4.70	0.096	1.20 (0.96–1.51)	2.43	0.119
	IL13	rs1800925	408	2.2	0.19	1045	3.4	0.19	0.39	0.823	1.00 (0.81–1.23)	0.00	0.961
	IL13	rs1295686	408	0.7	0.21	1045	1.9	0.18	2.65	0.266	1.18 (0.96–1.45)	2.35	0.126
	IL13	rs20541	408	3.9	0.20	1045	6.1	0.16	4.78	0.092	1.27 (1.02–1.57)	4.55	0.033
	IL4	rs2243250	408	2.9	0.18	1044	3.9	0.13	12.05	0.002	1.48 (1.18–1.85)	11.39	0.0007
	IL4	rs2070874	408	3.2	0.17	1045	4.2	0.13	8.63	0.013	1.39 (1.11–1.74)	7.77	0.005
	IL4	rs2243270	408	6.6	0.18	1045	4.7	0.14	8.54	0.014	1.38 (1.10–1.72)	7.55	0.006

Single SNP association statistics for all SNPs with positive findings and those used in haplotype analysis: (A) Cohort 1. (B) Total cohort. Association statistics for all 48 htSNPs genotyped in cohort 1 are available in table 2B in the online supplement.

Freq, frequency.