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The Journal of Clinical Investigation logoLink to The Journal of Clinical Investigation
. 1975 Feb;55(2):427–430. doi: 10.1172/JCI107947

Alpha-1-antitrypsin content in the serum, alveolar macrophages, and alveolar lavage fluid of smoking and nonsmoking normal subjects.

G N Olsen, J O Harris, J R Castle, R H Waldman, H J Karmgard
PMCID: PMC301762  PMID: 1079211

Abstract

The content of alpha-1-antitrypsin in the serum, alveolar lavage fluid, and alveolar macrophages of smokers and nonsmokers was studied. Bronchoalveolar lavage was used to obtain alveolar fluid and macrophages from normal volunteers, and alpha-1-antitrypsin and albumin were measured using the electroimmunodiffusion technique. The serum level of inhibitor was not different between the two groups, while the total lavage fliud content of alpha-1-antitrypsin was increased in the smokers. The level of alpha-1-antitrypsin was also significantly greater (P less than 0.001) in the alveolar macrophages of the smokers suggesting the possibility of chronically increased alveolar levels in the cigarette smoker as a possible protective mechanism against proteolysis.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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