Abstract
It is well established that a number of organic anions are excreted by the liver into bile in association with a marked increase in bile flow. Previous studies have shown that iodipamide (3,3'-(adipoyl-diimino)bis[2,4,6-triiodobenzoic acid]), the radiographic contrast material used for intravenous cholangiography, is a potent choleretic. Experiments were performed in unanesthetized dogs to determine if the increased bile flow produced by iodipamide is canalicular or ductular in origin, to quantitate the choleresis associated with iodipamide and taurocholate excretion, and to correlate these findings with the results of in vitro studies in which the osmotic activities of iodipamide and taurocholate in both isotonic saline and bile were determined. The plasma erythritol clearance increase linearly with the excretion of iodipamide, indicating that iodipamide stimulates canalicular bile flow. The choleretic potency of iodipamide (22 ml/mmol) is approximately 3 times that of taurocholate (7.8 ml/mmol), yet the osmotic activity of iodipamide in bile (1.5 mosmol/mmol) is only twice as great as that of taurocholate in bile (0.8 mosmol/mmol). It therefore appears that, per unit of effective osmotic solute secreted, iodipamide carries more water into the bile canaliculi than does taurocholate.
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- ANDERSEN B., USSING H. H. Solvent drag on non-electrolytes during osmotic flow through isolated toad skin and its response to antidiuretic hormone. Acta Physiol Scand. 1957 Jun 8;39(2-3):228–239. doi: 10.1111/j.1748-1716.1957.tb01425.x. [DOI] [PubMed] [Google Scholar]
- Admirand W. H., Small D. M. The physicochemical basis of cholesterol gallstone formation in man. J Clin Invest. 1968 May;47(5):1043–1052. doi: 10.1172/JCI105794. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Boyer J. L. Canalicular bile formation in the isolated perfused rat liver. Am J Physiol. 1971 Oct;221(4):1156–1163. doi: 10.1152/ajplegacy.1971.221.4.1156. [DOI] [PubMed] [Google Scholar]
- Erlinger S., Dhumeaux D., Berthelot P., Dumont M. Effect of inhibitors of sodium transport on bile formation in the rabbit. Am J Physiol. 1970 Aug;219(2):416–422. doi: 10.1152/ajplegacy.1970.219.2.416. [DOI] [PubMed] [Google Scholar]
- Erlinger S., Dhumeaux D. Mechanisms and control of secretion of bile water and electrolytes. Gastroenterology. 1974 Feb;66(2):281–304. [PubMed] [Google Scholar]
- FISCHER H. W. THE EXCRETION OF IODIPAMIDE: RELATION OF BILE AND URINE OUTPUTS TO DOSE. Radiology. 1965 Mar;84:483–491. doi: 10.1148/84.3.483. [DOI] [PubMed] [Google Scholar]
- Hoenig V., Preisig R. Organic-anionic choleresis in the dog: comparative effects of bromsulfalein, ioglycamide and taurocholate. Biomedicine. 1973 Jan;18(1):23–30. [PubMed] [Google Scholar]
- LANGECKER H., HARWART A., JUNKMANN K. 2,4,6-Trijod-3-acetaminobenzoesäure-Abkömmlinge als Kontrastmittel. Naunyn Schmiedebergs Arch Exp Pathol Pharmakol. 1953;220(3):195–206. [PubMed] [Google Scholar]
- MOORE E. W., DIETSCHY J. M. NA AND K ACTIVITY COEFFICIENTS IN BILE AND BILE SALTS DETERMINED BY GLASS ELECTRODES. Am J Physiol. 1964 May;206:1111–1117. doi: 10.1152/ajplegacy.1964.206.5.1111. [DOI] [PubMed] [Google Scholar]
- O'Máille E. R., Richards T. G., Short A. H. The influence of conjugation of cholic acid on its uptake and secretion: hepatic extraction of taurocholate and cholate in the dog. J Physiol. 1967 Apr;189(2):337–350. doi: 10.1113/jphysiol.1967.sp008172. [DOI] [PMC free article] [PubMed] [Google Scholar]
- PREISIG R., COOPER H. L., WHEELER H. O. The relationship between taurocholate secretion rate and bile production in the unanesthetized dog during cholinergic blockade and during secretin administration. J Clin Invest. 1962 May;41:1152–1162. doi: 10.1172/JCI104568. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Wheeler H. O., King K. K. Biliary excretion of lecithin and cholesterol in the dog. J Clin Invest. 1972 Jun;51(6):1337–1350. doi: 10.1172/JCI106930. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Wheeler H. O., Ramos O. L. DETERMINANTS OF THE FLOW AND COMPOSITION OF BILE IN THE UNANESTHETIZED DOG DURING CONSTANT INFUSIONS OF SODIUM TAUROCHOLATE. J Clin Invest. 1960 Jan;39(1):161–170. doi: 10.1172/JCI104015. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Wheeler H. O., Ross E. D., Bradley S. E. Canalicular bile production in dogs. Am J Physiol. 1968 Apr;214(4):866–874. doi: 10.1152/ajplegacy.1968.214.4.866. [DOI] [PubMed] [Google Scholar]
- ZAK B., BOYLE A. J. A simple method for the determination of organic bound iodine. J Am Pharm Assoc Am Pharm Assoc. 1952 May;41(5):260–262. doi: 10.1002/jps.3030410511. [DOI] [PubMed] [Google Scholar]