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. 1975 Apr;55(4):707–713. doi: 10.1172/JCI107980

NADPH oxidase deficiency in X-linked chronic granulomatous disease.

D C Hohn, R I Lehrer
PMCID: PMC301806  PMID: 235560

Abstract

We measured the cyanide-insensitive pyridine nucleotide oxidase activity of fractionated resting and phagocytic neutrophils from 11 normal donors, 1 patient with hereditary deficiency of myeloperoxidase, and 7 patients with X-linked chronic granulomatous disease (CGD). When measured under optimal conditions (at pH 5.5 and in the presence of 0.5 mM Mn++), NADPH oxidase activity increased fourfold with phagocytosis and was six-fold higher than with NADH. Phagocytic neutrophils from patients with CGD were markedly deficient in NADPH oxidase activity.

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Selected References

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