Figure 5.—

Complete locomotor profile of CASK-β mutants. All parameters of locomotion from Figure 4C are analyzed individually. The nine parameters are initial pause length (time to resume movement following air pulse), average bout length (average length of all bouts per animal), average pause length (average length of all pauses per animal), average speed (mean of all speeds while in motion), max speed (mean of single maximum speed per animal), average peak speed (mean of all maximum speeds per bout), average acceleration (mean of all accelerations while in motion), average deceleration (mean of decelerations while in motion), and max acceleration (mean of single maximum acceleration per animal). Loss of CASK-β leads to dose-dependent increases in motor initiation time, decreases in ability to maintain active movement, and decreases in speed and acceleration. Letters signify significant differences between groups (P < 0.05).