Skip to main content
NCBI home page
The Journal of Clinical Investigation logoLink to The Journal of Clinical Investigation
. 1975 Jun;55(6):1254–1258. doi: 10.1172/JCI108044

Lymphocytotoxic antibodies in family members of patients with systemic lupus erythematosus.

R J DeHoratius, R P Messner
PMCID: PMC301880  PMID: 1133171

Abstract

57% of sera from 124 relatives of 28 patients with systemic lupus erythematosus (SLE) were found to have antibody directed against lymphocytes. The incidence in 60 members of 16 control families was 3%. Both consanguineous and nonconsanguineous relatives had the antibody in their sera. 68% of close household contacts of the SLE patients showed lymphocytotoxic antibody whereas only 23% of consanguineous relatives who had no household contact with the probands had this antibody. These data suggest that environmental factors may be important in the pathogenesis of SLE.

Full text

PDF
1254

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Allison A. C., Denman A. M., Barnes R. D. Cooperating and controlling functions of thymus-derived lymphocytes in relation to autoimmunity. Lancet. 1971 Jul 17;2(7716):135–140. doi: 10.1016/s0140-6736(71)92306-3. [DOI] [PubMed] [Google Scholar]
  2. Buchanan W. W., Boyle J. A., Greig W. R., McAndrew R., Barr M., Anderson J. R., Goudie R. B. Distribution of certain autoantibodies in monozygotic and dizygotic twins. Ann Rheum Dis. 1966 Sep;25(5):463–468. doi: 10.1136/ard.25.5.463. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. DeHoratius R. J., Strickland R. G., Williams R. C., Jr T and B lymphocytes in acute and chronic hepatitis. Clin Immunol Immunopathol. 1974 Apr;2(3):353–360. doi: 10.1016/0090-1229(74)90053-1. [DOI] [PubMed] [Google Scholar]
  4. Goodman J. R., Sylvester R. A., Talal N., Tuffanelli D. L. Virus-like structures in lymphocytes of patients with systemic and discoid lupus erythematosus. Ann Intern Med. 1973 Sep;79(3):396–402. doi: 10.7326/0003-4819-79-3-396. [DOI] [PubMed] [Google Scholar]
  5. Grey H. M., Rabellino E., Pirofsky B. Immunoglobulins on the surface of lymphocytes. IV. Distribution in hypogammaglobulinemia, cellular immune deficiency, and chronic lymphatic leukemia. J Clin Invest. 1971 Nov;50(11):2368–2375. doi: 10.1172/JCI106735. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Grumet F. C., Coukell A., Bodmer J. G., Bodmer W. F., McDevitt H. O. Histocompatibility (HL-A) antigens associated with systemic lupus erythematosus. A possible genetic predisposition to disease. N Engl J Med. 1971 Jul 22;285(4):193–196. doi: 10.1056/NEJM197107222850403. [DOI] [PubMed] [Google Scholar]
  7. Györkey F., Sinkovics J. G., Min K. W., Györkey P. A morphologic study on the occurrence and distribution of structures resembling viral nucleocapsids in collagen diseases. Am J Med. 1972 Aug;53(2):148–158. doi: 10.1016/0002-9343(72)90125-8. [DOI] [PubMed] [Google Scholar]
  8. Haran-Chera N., Peled A. Thymus and bone marrow derived lymphatic leukaemia in mice. Nature. 1973 Feb 9;241(5389):396–398. doi: 10.1038/241396a0. [DOI] [PubMed] [Google Scholar]
  9. Horwitz D. A. Impaired delayed hypersensitivity in systemic lupus erythematosus. Arthritis Rheum. 1972 Jul-Aug;15(4):353–359. doi: 10.1002/art.1780150406. [DOI] [PubMed] [Google Scholar]
  10. Huang S. W., Lattos D. B., Nelson D. B., Reeb K., Hong R. Antibody-associated lymphotoxin in acute infection. J Clin Invest. 1973 May;52(5):1033–1040. doi: 10.1172/JCI107268. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Husby G., Blomhoff J. P., Skrede S., Elgjo K., Gjone E. Detection of immunoglobulins in paraffin-embedded liver biopsies. Studies in 100 patients with special regard to immunological findings in active chronic hepatitis. Scand J Gastroenterol. 1973;8(7):621–629. [PubMed] [Google Scholar]
  12. Jersild C., Fog T., Hansen G. S., Thomsen M., Svejgaard A., Dupont B. Histocompatibility determinants in multiple sclerosis, with special reference to clinical course. Lancet. 1973 Dec 1;2(7840):1221–1225. doi: 10.1016/s0140-6736(73)90970-7. [DOI] [PubMed] [Google Scholar]
  13. LEONHARDT T. FAMILY STUDIES IN SYSTEMIC LUPUS ERYTHEMATOSUS. Acta Med Scand. 1964;176:SUPPL 416–416:1+. [PubMed] [Google Scholar]
  14. Levine B. B., Stember R. H., Fotino M. Ragweed hay fever: genetic control and linkage to HL-A haplotypes. Science. 1972 Dec 15;178(4066):1201–1203. doi: 10.1126/science.178.4066.1201. [DOI] [PubMed] [Google Scholar]
  15. Lewis R. M., André-Schwartz J., Harris G. S., Hirsch M. S., Black P. H., Schwartz R. S. Canine systemic lupus erythematosus. Transmission of serologic abnormalities by cell-free filtrates. J Clin Invest. 1973 Aug;52(8):1893–1907. doi: 10.1172/JCI107373. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Lewis R. M., Tannenberg W., Smith C., Schwartz R. S. C-type viruses in systemic lupus erythematosus. Nature. 1974 Nov 1;252(5478):78–79. doi: 10.1038/252078a0. [DOI] [PubMed] [Google Scholar]
  17. Lies R. B., Messner R. P., Williams R. C., Jr Relative T-cell specificity of lymphocytotoxins from patients with systemic lupus erythematosus. Arthritis Rheum. 1973 May-Jun;16(3):369–375. doi: 10.1002/art.1780160312. [DOI] [PubMed] [Google Scholar]
  18. McDevitt H. O., Benacerraf B. Genetic control of specific immune responses. Adv Immunol. 1969;11:31–74. doi: 10.1016/s0065-2776(08)60477-0. [DOI] [PubMed] [Google Scholar]
  19. Mellors R. C., Huang C. Y. Immunopathology of NZB/BL mice. V. Viruslike (filtrable) agent separable from lymphoma cells and identifiable by electron microscopy. J Exp Med. 1966 Dec 1;124(6):1031–1038. doi: 10.1084/jem.124.6.1031. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Messner R. P. Clinical aspects of T- and B-lymphocytes in rheumatic diseases. Arthritis Rheum. 1974 Jul-Aug;17(4):339–346. doi: 10.1002/art.1780170402. [DOI] [PubMed] [Google Scholar]
  21. Messner R. P., Lindström F. D., Williams R. C., Jr Peripheral blood lymphocyte cell surface markers during the course of systemic lupus erythematosus. J Clin Invest. 1973 Dec;52(12):3046–3056. doi: 10.1172/JCI107503. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Mittal K. K., Rossen R. D., Sharp J. T., Lidsky M. D., Butler W. T. Lymphocyte cytotoxic antibodies in systemic lupus erythematosus. Nature. 1970 Mar 28;225(5239):1255–1256. doi: 10.1038/2251255a0. [DOI] [PubMed] [Google Scholar]
  23. Nies K. M., Brown J. C., Dubois E. L., Quismorio F. P., Friou G. J., Terasaki P. I. Histocompatibility (HL-A) antigens and lymphocytotoxic antibodies in systemic lupus erythematosus (SLE). Arthritis Rheum. 1974 Jul-Aug;17(4):397–402. doi: 10.1002/art.1780170409. [DOI] [PubMed] [Google Scholar]
  24. Shirai T., Mellors R. C. Natural cytotoxic autoantibody against thymocytes in NZB mice. Clin Exp Immunol. 1972 Sep;12(1):133–152. [PMC free article] [PubMed] [Google Scholar]
  25. Siegel M., Lee S. L., Widelock D., Gwon N. V., Kravitz H. A comparative family study of rheumatoid arthritis and systemic lupus erythematosus. N Engl J Med. 1965 Oct 21;273(17):893–897. doi: 10.1056/NEJM196510212731702. [DOI] [PubMed] [Google Scholar]
  26. Stastny P., Ziff M. Direct lysis of lymphocytes by complement in patients with systemic lupus erythematosus. Arthritis Rheum. 1971 Nov-Dec;14(6):733–736. doi: 10.1002/art.1780140608. [DOI] [PubMed] [Google Scholar]
  27. TERASAKI P. I., MCCLELLAND J. D. MICRODROPLET ASSAY OF HUMAN SERUM CYTOTOXINS. Nature. 1964 Dec 5;204:998–1000. doi: 10.1038/204998b0. [DOI] [PubMed] [Google Scholar]
  28. Terasaki P. I., Mottironi V. D., Barnett E. V. Cytotoxins in disease. Autocytotoxins in lupus. N Engl J Med. 1970 Oct 1;283(14):724–728. doi: 10.1056/NEJM197010012831403. [DOI] [PubMed] [Google Scholar]
  29. Williams R. C., Jr, DeBoard J. R., Mellbye O. J., Messner R. P., Lindström F. D. Studies of T- and B-lymphocytes in patients with connective tissue diseases. J Clin Invest. 1973 Feb;52(2):283–295. doi: 10.1172/JCI107184. [DOI] [PMC free article] [PubMed] [Google Scholar]
  30. Williams R. C., Jr, Emmons J. D., Yunis E. J. Studies of human sera with cytotoxic activity. J Clin Invest. 1971 Jul;50(7):1514–1524. doi: 10.1172/JCI106637. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Journal of Clinical Investigation are provided here courtesy of American Society for Clinical Investigation

RESOURCES