Table 1.
hCA I–mCA XV inhibition data with compounds 1–4.
| Isoform | Ki [µm][a] | ||||
|---|---|---|---|---|---|
| 1 | 2 | 3 | 4 | 5 | |
| hCA I | 9.1 | 8.3 | 9.7 | 9.4 | 7.0 |
| hCA II | 3.6 | 4.0 | 3.9 | 4.1 | 50 nm |
| hCA III | 9.5 | 8.4 | 9.1 | 7.5 | - |
| hCA IV | 4.3 | 4.6 | 3.9 | 4.4 | - |
| hCA VA | 4.6 | 4.2 | 4.4 | 4.0 | - |
| hCA VB | 4.3 | 4.0 | 4.4 | 3.8 | - |
| hCA VI | 3.5 | 3.2 | 3.9 | 3.6 | - |
| hCA VII | 3.4 | 3.6 | 3.8 | 3.6 | - |
| hCA IX | 9.5 | 10.0 | 9.3 | 9.2 | 27 nm |
| hCA XII | 4.0 | 4.5 | 4.7 | 4.8 | - |
| hCA XIII | 10.4 | 10.4 | 10.8 | 10.8 | - |
| hCA XIV | 7.2 | 6.7 | 6.8 | 7.1 | - |
| mCA XV | 2.8 | 3.1 | 4.9 | 4.7 | - |
[a]
Errors in the range of ± 10 % of the reported value from three different assays.