Skip to main content
PMC home page
The Journal of Clinical Investigation logoLink to The Journal of Clinical Investigation
. 1975 Oct;56(4):951–957. doi: 10.1172/JCI108175

Quantitation of immunocompetence in Hodgkin's disease.

G B Faguet
PMCID: PMC301951  PMID: 1159096

Abstract

In vitro cellular immunocompetence was investigated on 35 patients with Hodgkin's disease by studying their in vitro lymphocyte responsiveness to full range stimulation achieved by a spectrum of phytohemagglutinin concentrations. When compared to the normal lymphocyte profile elicited from 35 control subjects, the Hodgkin's patterns of response enabled the identification of a quantifiable lymphocyte defect present in most patients regardless of their clinical status. Increasing severity of this defect was found with progression of the disease and was most pronounced in patients with skin anergy and absolute lymphopenia. The marked abnormality observed in patients restudied after intensive therapy returned towards normal in patients achieving a long lasting, unmaintained complete remission. The data suggest the early presence of an intrinsic functional lymphocyte defect, increasing severity of which may lead to progressive immunoincompetence, reflected to vitro by imparied lymphocyte responsiveness and in vivo by skin anergy and ultimately lymphopenia.

Full text

PDF
951

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. AISENBERG A. C. LYMPHOCYTOPENIA IN HODGKIN'S DISEASE. Blood. 1965 Jun;25:1037–1042. [PubMed] [Google Scholar]
  2. AISENBERG A. C. Studies on delayed hypersensitivity in Hodgkin's disease. J Clin Invest. 1962 Nov;41:1964–1970. doi: 10.1172/JCI104654. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Aiuti F., Wigzell H. Function and distribution pattern of human T lymphocytes. II. Presence of T lymphocytes in normal humans and in humans with various immunodeficiency disorders. Clin Exp Immunol. 1973 Feb;13(2):183–189. [PMC free article] [PubMed] [Google Scholar]
  4. Brown R. S., Haynes H. A., Foley H. T., Godwin H. A., Berard C. W., Carbone P. P. Hodgkin's disease. Immunologic, clinical, and histologic features of 50 untreated patients. Ann Intern Med. 1967 Aug;67(2):291–302. doi: 10.7326/0003-4819-67-2-291. [DOI] [PubMed] [Google Scholar]
  5. Corder M. P., Young R. C., Brown R. S., DeVita V. T. Phytohemagglutinin-induced lymphocyte transformation: the relationship to prognosis of Hodgkin's disease. Blood. 1972 May;39(5):595–601. [PubMed] [Google Scholar]
  6. Cowther D., Fairley G. H., Sewell R. L. Significance of the changes in the circulating lymphoid cells in Hodgkin's disease. Br Med J. 1969 May 24;2(5655):473–477. doi: 10.1136/bmj.2.5655.473. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Eltringham J. R., Kaplan H. S. Impaired delayed-hypersensitivity responses in 154 patients with untreated Hodgkin's disease. Natl Cancer Inst Monogr. 1973 May;36:107–115. [PubMed] [Google Scholar]
  8. Faguet G. B., Balcerzak S. P., Lobuglio A. F. Lymphocyte sensitivity and cellular immunity in neoplasia. Biomedicine. 1973 Feb 10;19(2):43–47. [PubMed] [Google Scholar]
  9. Faguet G. B. Lymphocyte responsiveness to phytohemagglutinin (PHA): quantitative aspects and reproducibility. J Reticuloendothel Soc. 1974 Aug;16(2):114–121. [PubMed] [Google Scholar]
  10. Han T. Effect of sera from patients with Hodgkin's disease on normal lymphocyte response to phytohemagglutinin. Cancer. 1972 Jun;29(6):1626–1631. doi: 10.1002/1097-0142(197206)29:6<1626::aid-cncr2820290629>3.0.co;2-s. [DOI] [PubMed] [Google Scholar]
  11. Han T., Sokal J. E. Lymphocyte response to phytohemagglutinin in Hodgkin's disease. Am J Med. 1970 Jun;48(6):728–734. doi: 10.1016/s0002-9343(70)80008-0. [DOI] [PubMed] [Google Scholar]
  12. Hersh E. M., Harris J. E. Macrophage-lymphocyte interaction in the antigen-induced blastogenic response of human peripheral blood leukocytes. J Immunol. 1968 Jun;100(6):1184–1194. [PubMed] [Google Scholar]
  13. Hersh E. M., Irvin W. S. Blastogenic responses of lymphocytes from patients with untreated and treated lymphomas. Lymphology. 1969 Dec;2(4):150–160. [PubMed] [Google Scholar]
  14. Hersh E. M., Oppenheim J. J. Impaired in vitro lymphocyte transformation in Hodgkin's disease. N Engl J Med. 1965 Nov 4;273(19):1006–1012. doi: 10.1056/NEJM196511042731903. [DOI] [PubMed] [Google Scholar]
  15. Jackson S. M., Garrett J. V., Craig A. W. Lymphocyte transformation changes during the clinical course of Hodgkin's disease. Cancer. 1970 Apr;25(4):843–850. doi: 10.1002/1097-0142(197004)25:4<843::aid-cncr2820250413>3.0.co;2-1. [DOI] [PubMed] [Google Scholar]
  16. Jacobsson H., Blomgren H. Evidence for a loss of recirculating capacity of T-cells after antigenic stimulation. Clin Exp Immunol. 1973 Mar;13(3):439–453. [PMC free article] [PubMed] [Google Scholar]
  17. KELLY W. D., LAMB D. L., VARCO R. L., GOOD R. A. An investigation of Hodgkin's disease with respect to the problem of homotransplantation. Ann N Y Acad Sci. 1960 May 31;87:187–202. doi: 10.1111/j.1749-6632.1960.tb23192.x. [DOI] [PubMed] [Google Scholar]
  18. Lang J. M., Oberling F., Tongio M. M., Mayer S., Waitz R. Mixed-lymphocyte reaction as assay for immunological competence of lymphocytes from patients with hodgkin's disease. Lancet. 1972 Jun 10;1(7763):1261–1263. doi: 10.1016/s0140-6736(72)90982-8. [DOI] [PubMed] [Google Scholar]
  19. Levy R., Kaplan H. S. Impaired lymphocyte function in untreated Hodgkin's disease. N Engl J Med. 1974 Jan 24;290(4):181–186. doi: 10.1056/NEJM197401242900402. [DOI] [PubMed] [Google Scholar]
  20. Matchett K. M., Huang A. T., Kremer W. B. Impaired lymphocyte transformation in Hodgkin's disease. Evidence for depletion of circulating t-lymphocytes. J Clin Invest. 1973 Aug;52(8):1908–1917. doi: 10.1172/JCI107374. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. McIntyre O. R., Cole A. F. Variation in the response of normal lymphocytes to PHA. Int Arch Allergy Appl Immunol. 1969;35(2):105–118. doi: 10.1159/000230164. [DOI] [PubMed] [Google Scholar]
  22. Newberry W. M., Sanford J. P. Defective cellular immunity in renal failure: depression of reactivity of lymphocytes to phytohemagglutinin by renal failure serum. J Clin Invest. 1971 Jun;50(6):1262–1271. doi: 10.1172/JCI106604. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Newberry W. M., Shorey J. W., Sanford J. P., Combes B. Depression of lymphocyte reactivity to phytohemagglutinin by serum from patients with liver disease. Cell Immunol. 1973 Jan;6(1):87–97. doi: 10.1016/0008-8749(73)90009-9. [DOI] [PubMed] [Google Scholar]
  24. Order S. E., Porter M., Hellman S. Hodgkin's disease: evidence for a tumor-associated antigen. N Engl J Med. 1971 Aug 26;285(9):471–474. doi: 10.1056/NEJM197108262850901. [DOI] [PubMed] [Google Scholar]
  25. SCHIER W. W., ROTH A., OSTROFF G., SCHRIFT M. H. Hodgkin's disease and immunity. Am J Med. 1956 Jan;20(1):94–99. doi: 10.1016/0002-9343(56)90176-0. [DOI] [PubMed] [Google Scholar]
  26. Sokal J. E., Aungst C. W. Response to BCG vaccination and survival in advanced Hodgkin's disease. Cancer. 1969 Jul;24(1):128–134. doi: 10.1002/1097-0142(196907)24:1<128::aid-cncr2820240117>3.0.co;2-c. [DOI] [PubMed] [Google Scholar]
  27. Trubowitz S., Masek B., Del Rosario A. Lymphocyte response to phytohemagglutinin in Hodgkin's disease, lymphatic leukemia and lymphosarcoma. Cancer. 1966 Dec;19(12):2019–2023. doi: 10.1002/1097-0142(196612)19:12<2019::aid-cncr2820191228>3.0.co;2-h. [DOI] [PubMed] [Google Scholar]
  28. Wybran J., Chantler S., Fudenberg H. H. Isolation of normal T cells in chronic lymphatic leukaemia. Lancet. 1973 Jan 20;1(7795):126–129. doi: 10.1016/s0140-6736(73)90196-7. [DOI] [PubMed] [Google Scholar]
  29. Yachnin S., Allen L. W., Baron J. M., Svenson R. H. The potentiation of phytohemagglutinin-induced lymphocyte transformation by cell-cell interaction; a matrix hypothesis. Cell Immunol. 1972 Apr;3(4):569–589. doi: 10.1016/0008-8749(72)90120-7. [DOI] [PubMed] [Google Scholar]
  30. Young R. C., Corder M. P., Haynes H. A., DeVita V. T. Delayed hypersensitivity in Hodgkin's disease. A study of 103 untreated patients. Am J Med. 1972 Jan;52(1):63–72. doi: 10.1016/0002-9343(72)90008-3. [DOI] [PubMed] [Google Scholar]

Articles from Journal of Clinical Investigation are provided here courtesy of American Society for Clinical Investigation

RESOURCES