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. 1972 Feb;51(2):386–394. doi: 10.1172/JCI106824

Plasma Aldosterone Concentration at Delivery and during the Newborn Period

Inese Z Beitins 1,2,3, Francis Bayard 1,2,3, Lynne Levitsky 1,2,3, Isadore G Ances 1,2,3, Avinoam Kowarski 1,2,3, Claude J Migeon 1,2,3
PMCID: PMC302137  PMID: 5009121

Abstract

Aldosterone concentrations in plasma of women on normal sodium intake undergoing cesarean section were 3.7±1.4 ng/100 ml (mean±1 SD). These values were significantly lower (P < 0.001) than those observed in mothers on normal sodium diet, delivered by the vaginal route (14.9±7.0 ng/100 ml). A significant elevation (P < 0.001) of the concentrations was found if the mothers had been on sodium restriction and/or diuretics (44.9±24.2 ng/100 ml). In supine position, adult nonpregnant subjects have aldosterone concentrations in plasma of 1.7±1.4 ng/100 ml on normal sodium intake and of 16.7±8.1 ng/100 ml on low sodium diet.

Simultaneous determinations of aldosterone levels in cord blood showed that cord values were significantly higher than those of the corresponding mother (P < 0.01 by paired t test). However, values in cord blood of infants born to mothers on a normal sodium intake were significantly lower (P < 0.005) than those of infants whose mothers had required low sodium diet and/or diuretics during their pregnancy.

Aldosterone concentrations in plasma of infants 1-72 hr of age and born to mothers on normal sodium intake were 25.9±11.7 ng/100 ml (mean ±1 SD). These values were significantly lower (P < 0.005) than those of infants born to mothers on restricted sodium intake with or without diuretics (80.3±54.4 ng/100 ml). The concentrations at birth were not significantly different from those observed during the first 3 days of life (P > 0.6).

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Selected References

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