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. 1972 Apr;51(4):922–938. doi: 10.1172/JCI106887

Effects of Acute Volume Expansion and Altered Hemodynamics on Renal Tubular Function in Chronic Caval Dogs

Mortimer Levy 1,2,3
PMCID: PMC302206  PMID: 5014619

Abstract

It is well established that dogs with chronic partial constriction of the thoracic inferior vena cava develop sodium retention, ascites, and respond poorly to acute saline loading. A group of such chronic caval dogs, and a group of normal controls were studied during hydropenia, and again after acute saline loading by clearance and recollection micropuncture techniques. After volume expansion, the caval dogs excreted 52 μEq/min per kidney of sodium compared with 370 μEq/min per kidney for the normal controls. During hydropenia and after the saline infusions, single nephron filtration rates, fractional reabsorption of sodium within the proximal tubule, and proximal delivery of filtrate to the distal nephron were comparable in both groups of dogs.

Micropuncture of distal tubular segments confirmed that the loop of Henle was the major site for salt and water retention in the expanded caval dogs. Alteration of intrarenal hemodynamics by vasodilating one kidney and elevating systemic arterial blood pressure induced a normal natriuretic response in the saline-loaded caval dogs. Proximal tubular function remained unchanged and the loop of Henle appeared to be the major site responsive to these hemodynamic maneuvers. These same experiments in saline-loaded control dogs had no effect on function of the proximal or distal nephron and did not increase urinary excretion of sodium or water.

These experiments provide evidence that the loop of Henle is the major site for sodium retention in volume-expanded chronic caval dogs excreting minimal amounts of sodium.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BELL N. H., SCHEDL H. P., BARTTER F. C. AN EXPLANATION FOR ABNORMAL WATER RETENTION AND HYPOOSMOLALITY IN CONGESTIVE HEART FAILURE. Am J Med. 1964 Mar;36:351–360. doi: 10.1016/0002-9343(64)90161-5. [DOI] [PubMed] [Google Scholar]
  2. BRESLER E. H. The problem of the volume component of body fluid homeostasis. Am J Med Sci. 1956 Jul;232(1):93–104. doi: 10.1097/00000441-195607000-00014. [DOI] [PubMed] [Google Scholar]
  3. Bank N., Aynedjian H. S., Bansal V. K., Goldman D. M. Effect of acute hypertension on sodium transport by the distal nephron. Am J Physiol. 1970 Aug;219(2):275–280. doi: 10.1152/ajplegacy.1970.219.2.275. [DOI] [PubMed] [Google Scholar]
  4. Buckalew V. M., Jr, Puschett J. B., Kintzel J. E., Goldberg M. Mechanism of exaggerated natriuresis in hypertensive man: impaired sodium transport in the loop of Henle. J Clin Invest. 1969 Jun;48(6):1007–1016. doi: 10.1172/JCI106057. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Buentig W. E., Earley L. E. Demonstration of independent roles of proximal tubular reabsorption and intratubular load in the phenomenon of glomerulotubular balance during aortic constriction in the rat. J Clin Invest. 1971 Jan;50(1):77–89. doi: 10.1172/JCI106486. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Burg M. B., Orloff J. Control of fluid absorption in the renal proximal tubule. J Clin Invest. 1968 Sep;47(9):2016–2024. doi: 10.1172/JCI105888. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Cirksena W. J., Dirks J. H., Berliner R. W. Effect of thoracic cava obstruction on response of proximal tubule sodium reabsorption to saline infusion. J Clin Invest. 1966 Feb;45(2):179–186. doi: 10.1172/JCI105330. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. DAVIS J. O., HOLMAN J. E., CARPENTER C. C., URQUHART J., HIGGINS J. T., Jr AN EXTRA-ADRENAL FACTOR ESSENTIAL FOR CHRONIC RENAL SODIUM RETENTION IN PRESENCE OF INCREASED SODIUM-RETAINING HORMONE. Circ Res. 1964 Jan;14:17–31. doi: 10.1161/01.res.14.1.17. [DOI] [PubMed] [Google Scholar]
  9. DAVIS J. O., HOWELL D. S., GOODKIND M. J., HYATT R. E. Accumulation of ascites during maintenance of adrenalectomized dogs with thoracic inferior vena cava constriction on a high sodium diet without hormone therapy. Am J Physiol. 1956 Apr;185(1):230–234. doi: 10.1152/ajplegacy.1956.185.1.230. [DOI] [PubMed] [Google Scholar]
  10. DAVIS J. O., HOWELL D. S. Mechanisms of fluid and electrolyte retention in experimental preparations in dogs. II. With thoracic inferior vena cava constriction. Circ Res. 1953 Mar;1(2):171–178. doi: 10.1161/01.res.1.2.171. [DOI] [PubMed] [Google Scholar]
  11. DAVIS J. O., PECHET M. M., BALL W. C., Jr, GOODKIND M. J. Increased aldosterone secretion in dogs with right-sided congestive heart failure and in dogs with thoracic inferior vena cava constriction. J Clin Invest. 1957 May;36(5):689–694. doi: 10.1172/JCI103470. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. DIRKS J. H., CIRKSENA W. J., BERLINER R. W. THE EFFECTS OF SALINE INFUSION ON SODIUM REABSORPTION BY THE PROXIMAL TUBULE OF THE DOG. J Clin Invest. 1965 Jul;44:1160–1170. doi: 10.1172/JCI105223. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Davis B. B., Walter M. J., Murdaugh H. V., Jr Renal response to graded saline challenge. Am J Physiol. 1969 Dec;217(6):1604–1607. doi: 10.1152/ajplegacy.1969.217.6.1604. [DOI] [PubMed] [Google Scholar]
  14. Davis J. O., Johnston C. I., Howards S. S., Wright F. S. Humoral factors in the regulation of renal sodium excretion. Fed Proc. 1967 Jan-Feb;26(1):60–69. [PubMed] [Google Scholar]
  15. Dirks J. H., Seely J. F. Effect of saline infusions and furosemide on the dog distal nephron. Am J Physiol. 1970 Jul;219(1):114–121. doi: 10.1152/ajplegacy.1970.219.1.114. [DOI] [PubMed] [Google Scholar]
  16. FUHR J., KACZMARCZYK J., KRUTTGEN C. D. Eine einfache colorimetrische Methode zur Inulinbestimmung für Nieren-Clearance-Untersuchungen bei Stoffwechselgesunden und Diabetikern. Klin Wochenschr. 1955 Aug 1;33(29-30):729–730. doi: 10.1007/BF01473295. [DOI] [PubMed] [Google Scholar]
  17. Friedler R. M., Belleau L. J., Martino J. A., Earley L. E. Hemodynamically induced natriuresis in the presence of sodium retention resulting from constriction of the thoracic inferior vena cava. J Lab Clin Med. 1967 Apr;69(4):565–583. [PubMed] [Google Scholar]
  18. Gill J. R., Jr Edema. Annu Rev Med. 1970;21:269–280. doi: 10.1146/annurev.me.21.020170.001413. [DOI] [PubMed] [Google Scholar]
  19. Kaloyanides G. J., Cacciaguida R. J., Pablo N. C., Porush J. G. Increased sodium reabsorption in the proximal and distal tubule of caval dogs. J Clin Invest. 1969 Aug;48(8):1543–1551. doi: 10.1172/JCI106120. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. LARAGH J. H., VAN DYKE H. B., JACOBSON J., ADAMSONS K., Jr, ENGEL S. L. The experimental production of ascites in the dog with diabetes insipidus. J Clin Invest. 1956 Aug;35(8):897–903. doi: 10.1172/JCI103342. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. LEBRIE S. J., MAYERSON H. S. Influence of elevated venous pressure on flow and composition of renal lymph. Am J Physiol. 1960 May;198:1037–1040. doi: 10.1152/ajplegacy.1960.198.5.1037. [DOI] [PubMed] [Google Scholar]
  22. LEVINSKY N. G., LALONE R. C. SODIUM EXCRETION DURING ACUTE SALINE LOADING IN DOGS WITH VENA CAVAL CONSTRICTION. J Clin Invest. 1965 Apr;44:565–573. doi: 10.1172/JCI105169. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. LEVINSKY N. G., LALONE R. C. THE MECHANISM OF SODIUM DURESIS AFTER SALINE INFUSION IN THE DOG. J Clin Invest. 1963 Aug;42:1261–1276. doi: 10.1172/JCI104811. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. Levy M., Levinsky N. G. Proximal reabsorption and intrarenal pressure during colloid infusions in the dog. Am J Physiol. 1971 Feb;220(2):415–421. doi: 10.1152/ajplegacy.1971.220.2.415. [DOI] [PubMed] [Google Scholar]
  25. Lewy J. E., Windhager E. E. Peritubular control of proximal tubular fluid reabsorption in the rat kidney. Am J Physiol. 1968 May;214(5):943–954. doi: 10.1152/ajplegacy.1968.214.5.943. [DOI] [PubMed] [Google Scholar]
  26. Rector F. C., Jr, Sellman J. C., Martinez-Maldonado M., Seldin D. W. The mechanism of suppression of proximal tubular reabsorption by saline infusions. J Clin Invest. 1967 Jan;46(1):47–56. doi: 10.1172/JCI105510. [DOI] [PMC free article] [PubMed] [Google Scholar]
  27. SCHEDL H. P., BARTTER F. C. An explanation for and experimental correction of the abnormal water diuresis in cirrhosis. J Clin Invest. 1960 Feb;39:248–261. doi: 10.1172/JCI104035. [DOI] [PMC free article] [PubMed] [Google Scholar]
  28. Seely J. F., Dirks J. H. Micropuncture study of hypertonic mannitol diuresis in the proximal and distal tubule of the dog kidney. J Clin Invest. 1969 Dec;48(12):2330–2340. doi: 10.1172/JCI106199. [DOI] [PMC free article] [PubMed] [Google Scholar]
  29. Stein J. H., Reineck J. H., Osgood R. W., Ferris T. F. Effect of acetylcholine on proximal tubular sodium reabsorption in the dog. Am J Physiol. 1971 Jan;220(1):227–232. doi: 10.1152/ajplegacy.1971.220.1.227. [DOI] [PubMed] [Google Scholar]
  30. Stumpe K. O., Lowitz H. D., Ochwadt B. Fluid reabsorption in Henle's loop and urinary excretion of sodium and water in normal rats and rats with chronic hypertension. J Clin Invest. 1970 Jun;49(6):1200–1212. doi: 10.1172/JCI106334. [DOI] [PMC free article] [PubMed] [Google Scholar]

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