Abstract
The intravenous injection of prostaglandin E1 (PGE1) causes a dose-dependent relaxation of the lower esophageal sphincter (LES) in the intact, lightly anesthetized opossum. The action of PGE1 is not inhibited by the drugs that produce muscarinic or nicotinic cholinergic antagonism or alpha and beta adrenergic antagonism in the doses that inhibited the action of respective agonists. Moreover, this action is not affected by exogenous gastrin pentapeptide. The action of PGE1 on the LES is mimicked by isoproterenol, theophylline ethylenediamine, and dibutyryl cyclic AMP. Both theophylline, a phosphodiesterase inhibitor, and isoproterenol, an adenyl cyclase stimulator, added to the action of PGE1. On the other hand, adenyl cyclase inhibitor nicotinic acid, as well as phosphodiesterase stimulator, imidazole inhibited its action. Further, both nicotinic acid and imidazole inhibited the degree of LES relaxation produced by esophageal distension. These studies suggest that intracellular cyclic AMP may act as the “second messenger” in the regulation of the lower esophageal sphincter relaxation.
Full text
PDF
Images in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Axelsson J., Holmberg B. The effects of extracellularly applied ATP and related compounds on electrical and mechanical activity of the smooth muscle taenia coli from the guinea-pig. Acta Physiol Scand. 1969 Jan-Feb;75(1):149–156. doi: 10.1111/j.1748-1716.1969.tb04366.x. [DOI] [PubMed] [Google Scholar]
- Bennett A., Fleshler B. Prostaglandins and the gastrointestinal tract. Gastroenterology. 1970 Nov;59(5):790–800. [PubMed] [Google Scholar]
- Burnstock G., Campbell G., Satchell D., Smythe A. Evidence that adenosine triphosphate or a related nucleotide is the transmitter substance released by non-adrenergic inhibitory nerves in the gut. Br J Pharmacol. 1970 Dec;40(4):668–688. doi: 10.1111/j.1476-5381.1970.tb10646.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Cheung W. Y. Properties of cyclic 3',5'-nucleotide phosphodiesterase from rat brain. Biochemistry. 1967 Apr;6(4):1079–1087. doi: 10.1021/bi00856a017. [DOI] [PubMed] [Google Scholar]
- Christensen J., Daniel E. E. Effects of some autonomic drugs on circular esophageal smooth muscle. J Pharmacol Exp Ther. 1968 Feb;159(2):243–249. [PubMed] [Google Scholar]
- Christensen J., Lund G. F. Esophageal responses to distension and electrical stimulation. J Clin Invest. 1969 Feb;48(2):408–419. doi: 10.1172/JCI105998. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Kukovetz W. R., Pöch G. The action of imidazole on the effects of methyl-xanthines and catecholamines on cardiac contraction and phosphorylase activity. J Pharmacol Exp Ther. 1967 Jun;156(3):514–521. [PubMed] [Google Scholar]
- Lipshutz W., Hughes W., Cohen S. The genesis of lower esophageal sphincter pressure: its identification through the use of gastrin antiserum. J Clin Invest. 1972 Mar;51(3):522–529. doi: 10.1172/JCI106840. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Misiewicz J. J., Waller S. L., Anthony P. P., Gummer J. W. Achalasia of the cardia: pharmacology and histopathology of isolated cardiac sphincteric muscle from patients with and without achalasia. Q J Med. 1969 Jan;38(149):17–30. [PubMed] [Google Scholar]
- Skidmore I. F., Schönhöfer P. S., Kritchevsky D. Effects of nicotinic acid and some of its homologues on lipolysis, adenyl cyclase, phosphodiesterase and cyclic AMP accumulation in isolated fat cells. Pharmacology. 1971;6(6):330–338. doi: 10.1159/000136261. [DOI] [PubMed] [Google Scholar]
- Triner L., Nahas G. G., Vulliemoz Y., Overweg N. T., Verosky M., Habif D. V., Ngai S. H. Cyclic AMP and smooth muscle function. Ann N Y Acad Sci. 1971 Dec 30;185:458–476. doi: 10.1111/j.1749-6632.1971.tb45273.x. [DOI] [PubMed] [Google Scholar]