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. 1973 May;52(5):1093–1098. doi: 10.1172/JCI107274

The Effect of Chronic Sodium Loading and Sodium Restriction on Plasma Prostaglandin A, E and F Concentrations in Normal Humans

Randall M Zusman 1,2, David Spector 1,2, Burton V Caldwell 1,2, Leon Speroff 1,2, George Schneider 1,2, Patrick J Mulrow 1,2
PMCID: PMC302363  PMID: 4700484

Abstract

It has been suggested that prostaglandins may be involved in the control of sodium homeostasis. Prostaglandin A and prostaglandin E have been shown to increase renal blood flow and urinary sodium excretion and prostaglandin A has been shown to stimulate aldosterone release. The purpose of this study was to determine the effect of chronic sodium loading and sodium restriction on plasma prostaglandin A, E, and F concentrations.

Seven normal human volunteers were placed on three sodium intake diets: (a) ad lib. sodium intake, (b) high sodium intake, and (c) low sodium intake. Plasma prostaglandin A, E, and F concentrations were measured by radioimmunoassay.

Mean prostaglandin A levels on the ad lib. diet were 1.60 ng/ml. Prostaglandin A levels decreased 49% to 0.82 ng/ml on the high sodium intake and increased 34% to 2.14 ng/ml on the low sodium intake. Prostaglandin A levels increased 161% on the low sodium diet in comparison with levels on the high sodium diet. Plasma prostaglandin E and F concentrations did not change significantly during variation in sodium intake.

These results show that dietary sodium content markedly effects plasma prostaglandin A levels and that prostaglandins may play a role in the physiologic mechanism of sodium homeostasis.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Caldwell B. V., Burstein S., Brock W. A., Speroff L. Radioimmunoassay of the F prostaglandins. J Clin Endocrinol Metab. 1971 Aug;33(2):171–175. doi: 10.1210/jcem-33-2-171. [DOI] [PubMed] [Google Scholar]
  2. Carr A. A. Hemodynamic and renal effects of a prostaglandin, PGA 1, in subjects with essential hypertension. Am J Med Sci. 1970 Jan;259(1):21–26. doi: 10.1097/00000441-197001000-00003. [DOI] [PubMed] [Google Scholar]
  3. Carrière S., Friborg J., Guay J. P. Vasodilators, intrarenal blood flow, and natriuresis in the dog. Am J Physiol. 1971 Jul;221(1):92–98. doi: 10.1152/ajplegacy.1971.221.1.92. [DOI] [PubMed] [Google Scholar]
  4. Dunham E. W., Zimmerman B. G. Release of prostaglandin-like material from dog kidney during nerve stimulation. Am J Physiol. 1970 Nov;219(5):1279–1285. doi: 10.1152/ajplegacy.1970.219.5.1279. [DOI] [PubMed] [Google Scholar]
  5. Fichman M. P., Littenburg G., Brooker G., Horton R. Effect of prostaglandin A 1 on renal and adrenal function in man. Circ Res. 1972 Sep;31(9 Suppl):19–35. [PubMed] [Google Scholar]
  6. Haber E., Koerner T., Page L. B., Kliman B., Purnode A. Application of a radioimmunoassay for angiotensin I to the physiologic measurements of plasma renin activity in normal human subjects. J Clin Endocrinol Metab. 1969 Oct;29(10):1349–1355. doi: 10.1210/jcem-29-10-1349. [DOI] [PubMed] [Google Scholar]
  7. Hollenberg N. K., Epstein M., Guttmann R. D., Conroy M., Basch R. I., Merrill J. P. Effect of sodium balance on intrarenal distribution of blood flow in normal man. J Appl Physiol. 1970 Mar;28(3):312–317. doi: 10.1152/jappl.1970.28.3.312. [DOI] [PubMed] [Google Scholar]
  8. Horton E. W., Jones R. L. Prostaglandins A1,A2 and 19-hydroxy A1; their actions on smooth muscle and their inactivation on passage through the pulmonary and hepatic portal vascular beds. Br J Pharmacol. 1969 Nov;37(3):705–722. doi: 10.1111/j.1476-5381.1969.tb08509.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Johnston H. H., Herzog J. P., Lauler D. P. Effect of prostaglandin E1 on renal hemodynamics, sodium and water excretion. Am J Physiol. 1967 Oct;213(4):939–946. doi: 10.1152/ajplegacy.1967.213.4.939. [DOI] [PubMed] [Google Scholar]
  10. Karatzas N. B., Noble M. I., Saunders K. B., McIlroy M. B. Transmission of the blood flow pulse through the pulmonary arterial tree of the dog. Circ Res. 1970 Jul;27(1):1–9. doi: 10.1161/01.res.27.1.1. [DOI] [PubMed] [Google Scholar]
  11. Karatzas N. B., Noble M. I., Saunders K. B., McIlroy M. B. Transmission of the blood flow pulse through the pulmonary arterial tree of the dog. Circ Res. 1970 Jul;27(1):1–9. doi: 10.1161/01.res.27.1.1. [DOI] [PubMed] [Google Scholar]
  12. LEE J. B., COVINO B. G., TAKMAN B. H., SMITH E. R. RENOMEDULLARY VASODEPRESSOR SUBSTANCE, MEDULLIN: ISOLATION, CHEMICAL CHARACTERIZATION AND PHYSIOLOGICAL PROPERTIES. Circ Res. 1965 Jul;17:57–77. doi: 10.1161/01.res.17.1.57. [DOI] [PubMed] [Google Scholar]
  13. Lee S. J., Johnson J. G., Smith C. J., Hatch F. E. Renal effects of prostaglandin A1 in patients with essential hypertension. Kidney Int. 1972 Apr;1(4):254–262. doi: 10.1038/ki.1972.35. [DOI] [PubMed] [Google Scholar]
  14. Lonigro A. J., Terragno N. A., Malik K. U., McGiff J. C. A prostaglandin may mediate the renal vasodilator action of bradykinin. J Lab Clin Med. 1971 Dec;78(6):1016–1017. [PubMed] [Google Scholar]
  15. MUIRHEAD E. E., STIRMAN J. A., JONES F. Renal autoexplantation and protection against renoprival hypertensive cardiovascular disease and hemolysis. J Clin Invest. 1960 Feb;39:266–281. doi: 10.1172/JCI104037. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Martinez-Maldonado M., Tsaparas N., Eknoyan G., Suki W. N. Renal actions of prostaglandins: comparison with acetylcholine and volume expansion. Am J Physiol. 1972 May;222(5):1147–1152. doi: 10.1152/ajplegacy.1972.222.5.1147. [DOI] [PubMed] [Google Scholar]
  17. McGiff J. C., Crowshaw K., Terragno N. A., Lonigro A. J., Strand J. C., Williaon M. A., Lee J. B., Ng K. K. Prostaglandin-like substances appearing in canine renal venous blood during renal ischemia. Their patial characterization by pharmacologic and chromatographic procedures. Circ Res. 1970 Nov;27(5):765–782. doi: 10.1161/01.res.27.5.765. [DOI] [PubMed] [Google Scholar]
  18. McGiff J. C., Terragno N. A., Strand J. C., Lee J. B., Lonigro A. J., Ng K. K. Selective passage of prostaglandins across the lung. Nature. 1969 Aug 16;223(5207):742–745. doi: 10.1038/223742b0. [DOI] [PubMed] [Google Scholar]
  19. Nissen H. M. On lipid droplets in renal interstitial cells. II. A histological study on the number of droplets in salt depletion and acute salt repletion. Z Zellforsch Mikrosk Anat. 1968;85(4):483–491. [PubMed] [Google Scholar]
  20. Polet H., Levine L. Serum prostaglandin A isomerase. Biochem Biophys Res Commun. 1971 Dec 3;45(5):1169–1176. doi: 10.1016/0006-291x(71)90141-0. [DOI] [PubMed] [Google Scholar]
  21. Vander A. J. Direct effects of prostaglandin on renal function and renin release in anesthetized dog. Am J Physiol. 1968 Feb;214(2):218–221. doi: 10.1152/ajplegacy.1968.214.2.218. [DOI] [PubMed] [Google Scholar]
  22. Zusman R. M., Caldwell B. V., Speroff L., Behrman H. R. Radioimmunoassay of the A prostaglandins. Prostaglandins. 1972 Jul;2(1):41–53. doi: 10.1016/0090-6980(72)90028-7. [DOI] [PubMed] [Google Scholar]

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