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. 1973 May;52(5):1176–1186. doi: 10.1172/JCI107284

Purification and Biophysical Characterization of Hepatitis B Antigen

Chung Yong Kim 1,2,3, Jeremiah G Tilles 1,2,3
PMCID: PMC302373  PMID: 4121700

Abstract

Hepatitis B antigen (HB Ag) has been purified from serum by pepsin digestion and equilibrium sedimentation. The sedimentation coefficient, density, particle size, and electrophoretic mobility have been determined before and after purification and found to be unaltered. In addition, the diffusion constant and molecular weight of purified HB Ag have been documented.

Because the biophysical characteristics found are not consistant with those of any known virus, it is believed that native HB Ag is made up almost entirely of incomplete virus.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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