Table 1.

HFA Results for C1311.

Cell Line	C1311 Status*	Log10 IC50	SQ†	P‡	IP§	P‡	Overall	Overall P‡
T24T	Sensitive	-6.62	65.5	<.0001	71.0	.0006	68.3	<.0001
FL3	Intermediate	-5.45	78.6	.014	58.3	<.0001	68.4	.0002
UMUC1	Intermediate	-5.35	97.7	.067	60.5	<.0001	79.1	.02
KK47	Resistant	-4.84	80.1	<.0001	101.8	.57	90.9	.10

^*Relative sensitivity to C1311 of indicated cell line. Of cell lines adaptable to the hollow fiber assay, four cell types of varying in vitro sensitivities were selected for validation in vivo.

^†Average percentage of control growth across four replicates at the subcutaneous implantation site.

^‡Two-tailed P value for single-sample t test against the hypothesis that the inhibition was 0%.

^§Overage percentage of control growth across four replicates at the intraperitoneal implantation site.