Table 2.
Gene Ontology Term Enrichment among C1311-(A) and Benomyl-(B) Sensitized Yeast Strains.
| GOID* | GO_Term* | Cluster Frequency | Background Frequency | P† |
| (A) | ||||
| 6629 | Lipid metabolic process | 19/90 genes, 21.1% | 259/7166 background, 3.6% | 1.17E-07 |
| 44255 | Cellular lipid metabolic process | 18/90 genes, 20.0% | 254/7166 background, 3.5% | 6.51E-07 |
| 8610 | Lipid biosynthetic process | 12/90 genes, 13.3% | 140/7166 background, 2.0% | 5.66E-05 |
| 9987 | Cellular process | 81/90 genes, 90.0% | 4819/7166 background, 67.2% | .00015 |
| 16126 | Sterol biosynthetic process | 6/90 genes, 6.7% | 33/7166 background, 0.5% | .00111 |
| 6694 | Steroid biosynthetic process | 6/90 genes, 6.7% | 33/7166 background, 0.5% | .00111 |
| 9058 | Biosynthetic process | 46/90 genes, 51.1% | 2011/7166 background, 28.1% | .00112 |
| 44249 | Cellular biosynthetic process | 45/90 genes, 50.0% | 1994/7166 background, 27.8% | .00239 |
| 16129 | Phytosteroid biosynthetic process | 5/90 genes, 5.6% | 26/7166 background, 0.4% | .0059 |
| 6696 | Ergosterol biosynthetic process | 5/90 genes, 5.6% | 26/7166 background, 0.4% | .0059 |
| 16125 | Sterol metabolic process | 6/90 genes, 6.7% | 46/7166 background, 0.6% | .0082 |
| 6631 | Fatty acid metabolic process | 6/90 genes, 6.7% | 46/7166 background, 0.6% | .0082 |
| 8202 | Steroid metabolic process | 6/90 genes, 6.7% | 46/7166 background, 0.6% | .0082 |
| 16128 | Phytosteroid metabolic process | 5/90 genes, 5.6% | 28/7166 background, 0.4% | .00864 |
| 8204 | Ergosterol metabolic process | 5/90 genes, 5.6% | 28/7166 background, 0.4% | .00864 |
| (B) | ||||
| 43486 | Histone exchange | 5/33 genes, 15.2% | 10/7166 genes, 0.1% | 4.52E-08 |
| 7021 | Tubulin complex assembly | 4/33 genes, 12.1% | 5/7166 genes, 0.1% | 2.24E-07 |
| 43044 | ATP-dependent chromatin remodeling | 5/33 genes, 15.2% | 29/7166 genes, 0.4% | 2.00E-05 |
| 7023 | Post-chaperonin tubulin folding pathway | 3/33 genes, 9.1% | 5/7166 genes, 0.1% | .00011 |
| 34728 | Nucleosome organization | 5/33 genes, 15.2% | 51/7166 genes, 0.7% | .00037 |
| 43933 | Macromolecular complex subunit organization | 11/33 genes, 33.3% | 470/7166 genes, 6.6% | .00054 |
| 34621 | Cellular macromolecular complex subunit organization | 10/33 genes, 30.3% | 392/7166 genes, 5.5% | .00077 |
| 6338 | Chromatin remodeling | 5/33 genes, 15.2% | 76/7166 genes, 1.1% | .00268 |
| 6457 | Protein folding | 5/33 genes, 15.2% | 86/7166 genes, 1.2% | .00488 |
*
GOID and GO Terms from the Gene Ontology Consortium, www.geneontology.org, identified by GO::TermFinder.
†
Bonneferoni-corrected P value for enrichment of indicated term among yeast ORF knockout strains identified as exhibiting reduced fitness on growth with C1311 or benomyl (cluster frequency) to the background frequency of such GO terms in the genome. All GOIDs presented were associated with an FDR approximating 0%.